Purification of recombinant human interferon-ε and oligonucleotide microarray analysis of interferon-ε-regulated genes

Peng, Fuwang; Duan, Zhaojun; Zheng, Lei; Xie, Zhiping; Gao, Han‐chun; Zhang, Hui; Li, Wuping; Hou, Yong

doi:10.1016/j.pep.2006.12.013

Cited by 37 publications

(34 citation statements)

References 22 publications

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“…We hypothesized that IFNE function on vitiligo may converge with previous reports, because the role of IFNE in antiviral immune responses (Peng et al, 2007) and the pathway stimulated by IFNE (Matsumiya et al, 2007), is similar to the immune modulating actions of other IFNs (Dong et al, 2011;Lu et al, 2012). However, study exclusively investigating IFNE function are few, and there is only one study reporting the association between rs1125488 and heart rate (Melton et al, 2010); however, it was not in our study.…”

Section: Discussionsupporting

confidence: 48%

“…IFNE is induced by many factors including proinfammatory cytokines and viruses, and the biological activities of IFNE act through type I IFN receptors (Hardy et al, 2004). IFNE has a role in control of mucosal immunity and cellular maintenance (Matsumiya et al, 2007;Peng et al, 2007;Xi et al, 2012), and such functions may be related to vitiligo via dendrite cell responses (Wang et al, 2011) and keratinocyte apoptosis (Lee, 2012). However, no study has investigated the association between any of IFNE polymorphisms and vitiligo, which may help elucidating the biological roles of IFNE in dermatological immune response.…”

Section: Introductionmentioning

confidence: 99%

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Association study between nonsense polymorphism (rs2039381, Gln71Stop) of Interferon-ε and susceptibility to vitiligo in Korean population

Cho

Kim

Lim

et al. 2013

Immunological Investigations

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Interferons (IFNs) are related to autoimmune responses. IFN-epsilon (IFNE) is included in IFN family, and may modulate immunological functions. Inflammation modulating functions of IFNE may be related with the pathophysiology of vitiligo. To investigate the association of nonsense polymorphism (rs2039381, Gln71Stop) of interferon-ε (IFNE) and susceptibility to vitiligo, we conducted a case-control association study in 265 non-segmental vitiligo (NSV) patients and 320 healthy controls. The nonsense single nucleotide polymorphism (SNP) (rs2039381, Gln71Stop) of IFNE was genotyped by direct sequencing. Multiple logistic regression models (log-additive, dominant, and recessive models) were applied to determine odds ratios (OR), 95% confidence interval (CI), and p values. The rs2039381 (Gln71Stop) of IFNE did not show significant differences between NSV patient group and control group. However, we found that in childhood onset NSV groups, the IFNE nonsense polymorphism (rs2039381, Gln71Stop) showed a significant association. There was significantly different distribution of nonsense polymorphism of rs2039381 (Gln71Stop) of IFNE between NSV patients (childhood <18 years) and control subjects. This study suggests that rs2039381 (Gln71Stop) polymorphism of IFNE may be related to onset time of vitiligo in NSV patients.

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Section: Discussionsupporting

confidence: 48%

Section: Introductionmentioning

confidence: 99%

Association study between nonsense polymorphism (rs2039381, Gln71Stop) of Interferon-ε and susceptibility to vitiligo in Korean population

Cho

Kim

Lim

et al. 2013

Immunological Investigations

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“…The immune-modulatory function of IFN-ε has been investigated with respect to NK cell function. IFN-ε potently promotes NK cell cytotoxicity (26), which may play a role in protection against chlamydial infection of the female genital tract (58). Similarly, IFN-ε induced more robust phagocytosis and ROS production in 6 hours than IFN-α, suggesting a role in the initial innate immune response.…”

Section: Discussionmentioning

confidence: 99%

IFN-ε protects primary macrophages against HIV infection

Tasker¹,

Subbian

Gao

et al. 2016

JCI Insight

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“…Other differences exist between IFN-ε and other IFNs. First, the antiviral, natural killer cell-cytotoxicity activity and antiproliferative activities of IFN-ε are weaker than IFN-α and IFN-β [27]. Second, some studies showed that IFN-ε exhibits antiviral activity against cells derived from species that have near relatives and are expected to be homologous cells [23, 25].…”

Section: Biological Activities Of Type I Ifnsmentioning

confidence: 99%

Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection

Gong

Zhao

et al. 2018

Cell Physiol Biochem

139

111

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The interferons (IFNs) are a primary defense against pathogens because of the strong antiviral activities they induce. IFNs can be classified into three groups: type I, type II and type III, according to their genetic, structural, and functional characteristics and their receptors on the cell surface. The type I IFNs are the largest group and include IFN-α, IFN-β, IFN-ε, IFN-ω, IFN-κ, IFN-δ, IFN-τ and IFN-ζ. The use of IFNs for the treatment of viral infectious diseases on their antiviral activity may become an important therapeutic option, for example, IFN-α is well known for the successful treatment of hepatitis B and C virus infections, and interest is increasing in the antiviral efficacy of other novel IFN classes and their potential applications. Therefore, in this review, we summarize the recent progress in the study of the biological activities of all the type I IFN classes and their potential applications in the treatment of infections with immunodeficiency virus, hepatitis viruses, and influenza viruses.

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Purification of recombinant human interferon-ε and oligonucleotide microarray analysis of interferon-ε-regulated genes

Cited by 37 publications

References 22 publications

Association study between nonsense polymorphism (rs2039381, Gln71Stop) of Interferon-ε and susceptibility to vitiligo in Korean population

Association study between nonsense polymorphism (rs2039381, Gln71Stop) of Interferon-ε and susceptibility to vitiligo in Korean population

IFN-ε protects primary macrophages against HIV infection

Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection

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