Purification of organic acids by chromatography: Adsorption isotherms and impact of elution flow rate

Blanc, Claire-Line; Theoleyre, Marc-André; Lutin, Florence; Pareau, Dominique; Stambouli, Moncef

doi:10.1016/j.seppur.2014.11.032

Cited by 17 publications

(11 citation statements)

References 20 publications

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“…In a previous work dealing with the purification of lactic, succinic and citric acids by chromatography with a strong anionic resin (quaternary ammonium), the Langmuir model fitted well with the experimental equilibrium isotherms obtained by frontal analysis [18].…”

supporting

confidence: 62%

“…Preparative chromatography is an efficient separation technique which is spreading in different industrial fields. For several years now, anionic resins have been performed for the citric acid purification, however uptake mechanisms are still not well known.In a previous work [18], peaks corresponding to succinic and citric acids exhibited singular tailing and delay which could not be explained only by the Langmuir model.…”

Section: Resultsmentioning

confidence: 68%

“…So, the elution profiles were only influenced by 3 parameters: the plate number N, the polymer matrix uptake capacity equated to and the equilibrium constant of AH uptake on resin polymer matrixKs AH /mat equated to . For lactic and succinic acids, the resin uptake capacity and the equilibrium constant have significant error margin because it was not possible to get enough experimental points in the nonlinear region of equilibrium isotherms [18].…”

Section: Simulation Withonly the Langmuir Model Andcoefficients Of Eqmentioning

confidence: 99%

“…According to our previous study [18], the plate number Nwas set to250for the 3 organic acids. It corresponds to the experimental value obtained by pulse testswith lactic acid whose symmetric profile is the most appropriate to characterize axial dispersion.The plate number N 13 was considered equal for all species.…”

Section: Simulation Withonly the Langmuir Model Andcoefficients Of Eqmentioning

confidence: 99%

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Purification of organic acids by chromatography with strong anionic resins: Investigation of uptake mechanisms

Lemaire

Blanc

Lutin³

et al. 2016

Journal of Chromatography A

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Bio-based organic acids are promising renewable carbon sources for the chemical industry. However energy-consuming purification processes are used, like distillation or crystallization, to reach high purities required in some applications. That is why preparative chromatography was studied as an alternative separation technique. In a previous work dealing with the purification of lactic, succinic and citric acids, the Langmuir model was insufficient to explain the elution profiles obtained with a strong anionic resin. Consequently the Langmuir model was coupled with a usual ion-exchange model to take into account the retention of their conjugate bases (<2%), which are commonly neglected at low pH (<1.5). Elution simulations with both uptake mechanisms fitted very well with experimental pulse tests. Only two parameters were optimized (equilibrium constant of acid uptake and ion-exchange selectivity coefficient of conjugate base) and their value were coherent with experimental and resin suppliers' data. These results confirmed that the singular tailing and apparent delay observed with succinic and citric acids can be explained by the high affinity of succinate and citrate for resin cationic sites. The model was implemented in a preparative chromatography simulation program in order to optimize operating parameters of our pilot-scale ISMB unit (Improved Simulated Moving Bed). The comparison with experimental ISMB profiles was conclusive.

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supporting

confidence: 62%

Section: Resultsmentioning

confidence: 68%

Section: Simulation Withonly the Langmuir Model Andcoefficients Of Eqmentioning

confidence: 99%

Section: Simulation Withonly the Langmuir Model Andcoefficients Of Eqmentioning

confidence: 99%

See 2 more Smart Citations

Purification of organic acids by chromatography with strong anionic resins: Investigation of uptake mechanisms

Lemaire

Blanc

Lutin³

et al. 2016

Journal of Chromatography A

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show abstract

“…Instead, sample concentration, load rate and load volume have been found to be significant factors. In addition, height/diameter ratio, wash volume, ethanol concentration, elution rate and elution volume were found to affect the yield and purity of products [30][31][32][33]. The risk priority number scores were used as the criterion to identify the CPPs.…”

Section: Selection Of Cppsmentioning

confidence: 99%