Purification of Lactic Acid Produced by Fermentation: Focus on Non-traditional Distillation Processes

Komesu, Andrea; Maciel, Maria Regina Wolf; Oliveira, Johnatt Allan Rocha de; Martins, Luiza Helena da Silva; Filho, Rubens Maciel

doi:10.1080/15422119.2016.1260034

Cited by 56 publications

(52 citation statements)

References 59 publications

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“…In this context, lactic acid (LA) is a prime example of a platform molecule in biochemical production processes . LA has several applications demonstrating strong market growth, including (i) generation of multiple commodity and intermediate chemicals, for example pyruvic acid, acetaldehyde; (ii) production of biodegradable polymers such as poly lactic acid (PLA) exploited in the food industry (packaging) as well as pharmaceutical industry, for example internal drug dosing; (iii) manufacture of hygiene products for cosmetic industry; and (iv) use in the food and beverage sector as a preservative . Global LA production is estimated to be in excess of 500 000 tonne per year (t/year) .…”

Section: Introductionmentioning

confidence: 99%

“…Current fermentation‐based processes for LA production are characterized by several technology barriers, namely (i) convention purification methods generate large quantities of gypsum as a by–product, with obvious environmental burdens since up to 1 kg gypsum per 1 kg LA produced was reported, and (ii) expensive purification requirements. However, gypsum‐free reactive distillation is a promising alternative and an environmentally friendly technology, whereby LA can be recovered at high purity . Although a broad variety of technical aspects of LA production from a biological point of view were extensively studied, there is a distinct paucity in literature on the techno‐economic evaluation of LA production from lignocellulose, especially from a biorefinery point of view.…”

Section: Introductionmentioning

confidence: 99%

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Multi‐criteria analysis of a biorefinery for co‐production of lactic acid and ethanol from sugarcane lignocellulose

Mandegari

Farzad

Rensburg

2017

Biofuels Bioprod Bioref

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Biorefineries are regarded as a key enabler to facilitate the transition toward a sustainable and low carbon bioeconomy. In this study, alternative lignocellulose biorefineries annexed to a typical sugar mill were investigated to co‐produce ethanol (EtOH), lactic acid (LA), and/or electricity, utilizing bagasse and a component of harvesting residues (brown leaves) as feedstock. Studied scenarios included EtOH as the sole product from glucose and xylose (Scenario 1), LA as the sole product from these two sugars (Scenario 2), EtOH from glucose and LA from xylose (Scenario 3), and EtOH from xylose and LA from glucose (Scenario 4), all of which were associated with some level of export electricity production. Aspen Plus® simulations of the scenarios were developed considering all supplementary units, such as evaporation, water treatment, boiler, and steam/power generation in addition to the process units required for the main product streams. Economic evaluation, energy assessment, and environmental life cycle assessment (LCA) were carried out on the developed simulations, in a multi‐criteria analysis of the desirability of each scenario. To service the combined energy demands of a sugar mill and annexed biorefinery, a 35 to 40% bypass of lignocellulose directly to the boiler section was required to achieve integrated scenarios that were energy self‐sufficient, i.e., not dependent on external (fossil) energy sources. Scenario 2 was economically most attractive with the highest internal rate of return (IRR) of 31.1%, whereas Scenario 1 had the lowest IRR of 10.0%. Scenarios 2 and 4 were economically the most robust, with the least sensitivity to variations in the key economic drivers, i.e., EtOH, LA and enzymes. The LCA suggested that LA producing scenarios introduced environmental burdens that were marginally higher than Scenario 1, due to higher consumption of processing chemicals. Overall, Scenario 4 was found to be the most desirable biorefinery scenario, by balancing financial and environmental considerations. © 2017 Society of Chemical Industry and John Wiley & Sons, Ltd

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multi‐criteria analysis of a biorefinery for co‐production of lactic acid and ethanol from sugarcane lignocellulose

Mandegari

Farzad

Rensburg

2017

Biofuels Bioprod Bioref

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“…Details of the equipment can be seen in Komesu et al (2014). In addition, the theoretical aspects can be found in Komesu et al (2016).…”

Section: Short Path Evaporationmentioning

confidence: 99%

“…In addition to lactic acid and water, fermentation broth also contains a variety of by-products (Komesu et al 2016), which could hinder the purification. When fermentation-derived lactic acid without prior purification is used in a short path distillation, residual sugars, such as glucose, xylose, sucrose, and others can be present in the fermentation mixture.…”

Section: Introductionmentioning

confidence: 99%

Influence of Residual Sugars on the Purification of Lactic Acid Using Short Path Evaporation

et al. 2017

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Short path evaporation (SPE) is a promising separation technique for the purification of lactic acid from fermentation broth. This study investigated the influence of residual sugars, such as glucose, xylose, and sucrose, on the purification of lactic acid using SPE. A 2 3 factorial experimental design was performed in the experimental range from 5 g·L -1 to 15 g·L -1 for glucose, xylose, and sucrose concentrations. Glucose and sucrose concentrations did not have significant effects on the process of lactic acid concentration in the range used for this study. Xylose in high concentration was found to reduce the lactic acid concentration process performance. An increase in the boiling temperature of the mixture by the ebullioscopy effect possibly hindered the evaporation of the mixture.

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“…Molecular distillation and reactive distillation were reviewed in previous work (Komesu et al 2016). Komesu et al (2017).…”

Section: Introductionmentioning

confidence: 99%

Separation and Purification Technologies for Lactic Acid – A Brief Review

Komesu¹,

Maciel²,

Filho³

2017

BioResources

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Lactic acid is an important platform chemical with a wide range of applications. Production of lactic acid by fermentation is advantageous because renewable and low cost raw materials can be used as substrates. After fermentation, the broth needs to be purified to obtain pure lactic acid for further uses. Thus, efficient downstream processes are very important because they account for 50% of the production costs. This review discusses different processes that are currently employed for lactic acid recovery, focusing on precipitation, solvent extraction, and separation with membranes. Advances in such recovery processes and drawbacks that limit the application of these technologies at the industrial level are also presented.

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Purification of Lactic Acid Produced by Fermentation: Focus on Non-traditional Distillation Processes

Cited by 56 publications

References 59 publications

Multi‐criteria analysis of a biorefinery for co‐production of lactic acid and ethanol from sugarcane lignocellulose

Multi‐criteria analysis of a biorefinery for co‐production of lactic acid and ethanol from sugarcane lignocellulose

Influence of Residual Sugars on the Purification of Lactic Acid Using Short Path Evaporation

Separation and Purification Technologies for Lactic Acid – A Brief Review

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