Purification by Sublimation

Holden, Claire; Bryant, Howard S.

doi:10.1080/01496396908052233

Cited by 16 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among many purification techniques like preparative chromatography [7], phase-separation-based methods, etc., crystallization is one of the most employed techniques to purify chemical species. It offers a large panel of methods that can be combined when appropriate, e.g., solventassisted crystallization [8,9], crystallization from the melt [10] or from the gas phase [11].…”

Section: Introductionmentioning

confidence: 99%

Phenanthrene Purification: Comparison of Zone Melting and Co‐Crystallization

Burel¹,

Vlieg²,

Mignot³

et al. 2016

Chem Eng & Technol

View full text Add to dashboard Cite

The purification of phenanthrene is a prerequisite before studying its solid-solid phase transition at the molecular scale. Two purification methods, namely, zone melting and co-crystallization with 3,5-dinitrobenzoic acid, were separately studied and compared, in view of reaching ultrapurity which means a purity of > 99.9 mol %. An explanation of the relationship between the efficiency of both techniques by using phase diagrams has been attempted. A novel strategy is proposed to optimize phenanthrene ultrapurification based on a combination of the two methods.

show abstract

Section: Introductionmentioning

confidence: 99%

Phenanthrene Purification: Comparison of Zone Melting and Co‐Crystallization

Burel¹,

Vlieg²,

Mignot³

et al. 2016

Chem Eng & Technol

View full text Add to dashboard Cite

show abstract

“…Pharmaceutical crystal engineering is a powerful tool for designing new pharmaceutical solids with desired physical and chemical properties to facilitate drug development. , Among the crystal engineering strategies, the design of multicomponent pharmaceutical crystals (e.g., salts, cocrystals, hydrates, and solvates) with substances that are generally recognized as safe (GRAS) has the most flexibility to modulate drug properties. , Crystal engineering has been used to improve several important pharmaceutical properties, including solubility, permeability, bioavailability, stability, grindability, tabletability, and taste . Sublimation is a critical physical phenomenon underlying a number of important industrial processes, e.g., purification, , freeze-drying, , and dye sublimation printing . However, study of this property is scarce in the field of pharmaceutical crystal engineering, , likely due to the rare occurrence of excessive sublimation under ambient condition by most pharmaceutical crystals.…”

Section: Introductionmentioning

confidence: 99%

“…3,4 Crystal engineering has been used to improve several important pharmaceutical properties, including solubility, 5 permeability, 6 bioavailability, 7 stability, 8 grindability, 9 tabletability, 10 and taste. 11 Sublimation is a critical physical phenomenon underlying a number of important industrial processes, e.g., purification, 12,13 freeze-drying, 14,15 and dye sublimation printing. 16 However, study of this property is scarce in the field of pharmaceutical crystal engineering, 17,18 likely due to the rare occurrence of excessive sublimation under ambient condition by most pharmaceutical crystals.…”

Section: Introductionmentioning

confidence: 99%

Reducing the Sublimation Tendency of Ligustrazine through Salt Formation

Wang

et al. 2020

Crystal Growth & Design

View full text Add to dashboard Cite

Two new salts of ligustrazine (tetramethylpyrazine, TMP) with the sweeteners saccharine (SAC) and acesulfame (ACS) have been synthesized through the anion exchange reaction. Single crystals of the new forms were prepared, and their structures were determined. The stability of the new salts against heat and humidity was tested and compared to the commercial hydrochloride and phosphate salts. The sublimation kinetics at various temperatures was analyzed using the Arrhenius equation. The results indicated that TMP-ACS exhibits significantly reduced sublimation tendency and hygroscopicity, which make it a more suitable salt for developing a tablet with acceptable shelf stability than the salts currently used in commercial products.

show abstract

“…5-When the most conventional separation methods of distillation , solvent extraction , adsorption, etc. are either impossible or highly expensive (7) .…”

mentioning

confidence: 99%

Mathematical Model For Estimation of Desublimated Solid Layer Thickness and Surface Temperature

Shawki Abdul-Majeed

2008

ETJ

View full text Add to dashboard Cite

The thickness of the desublimatd solid layer is an important parameter required for evaluation of such desublimation process, especially in the case of solid layers production needed for special applications. A mathematical model has been derived based on the analogy of heat and mass transfer to calculate the solid layer thickness of the desublimated layer during the operation period. The prediction of thickness from the derived model is based on the data related to the applied experimental conditions as well as the physical properties of the vapour-gas mixture inside desublimator. The calculated thickness from the model has been used to calculate the temperature gradient of the solid layer surface during the run period.

show abstract

Purification by Sublimation

Cited by 16 publications

References 5 publications

Phenanthrene Purification: Comparison of Zone Melting and Co‐Crystallization

Phenanthrene Purification: Comparison of Zone Melting and Co‐Crystallization

Reducing the Sublimation Tendency of Ligustrazine through Salt Formation

Mathematical Model For Estimation of Desublimated Solid Layer Thickness and Surface Temperature

Contact Info

Product

Resources

About