Purification and partial characterization of the major allergen, Cav p 1, from guinea pig Cavia porcellus

Abstract

Although the physicochemical characteristics of isolated Cav p 1 are very similar to those for other rodent allergens and furthermore partial sequence identity with Mus m 1 was found, it is clearly shown here to be an immunologically independent major allergen.

Animal‐derived lipocalin allergens exhibit immunoglobulin E cross‐reactivity

“…Although studies on animal allergen extracts suggest that lipocalin allergens can show IgE cross-reactivity [7,8], IgE cross-reactivity with natural or recombinat lipocalins have only been reported between Cav p 1 and Cav p 2 (the major allergens of guinea pig) [9], and between Can f 1 and Can f 2 (major and minor allergens of dog, respectively) [10].…”

Risk factors associated with airway allergic diseases from exposure to laboratory animal allergens among veterinarians

“…The physicochemical characteristics of guinea pig allergens, especially Cav p 1 is also very similar to the allergens of other rodents, mainly mouse (Fahlbusch et al 2002).…”

Sensitization to Horse Allergens in Italy: A Multicentre Study in Urban Atopic Subjects without Occupational Exposure

“…Our findings may also indicate a cross-reaction between horse allergen [30] and the major allergens of several mammalian species, like cows [31], dogs [32], guinea pigs [33], rabbits [34], rodents [35] and, recently, cats [36]. In fact, all the allergens of these animals are lipocalins, which are typically small proteins whose major feature is the ability to bind small hydrophobic molecules such as steroids [37].…”