Purification and Identification of Components of γ-Oryzanol in Rice Bran Oil

Xu, Zhimin; Godber, John

doi:10.1021/jf981175j

Cited by 334 publications

(251 citation statements)

References 9 publications

(38 reference statements)

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“…40) Rice bran also contains 3000 mg/kg OZ, which is a mixture of 10 ferulate esters of triterpene alcohol. 41) In our study, the fatty acid profile of RB-SCE was similar to those stated in previous reports. However, the minor components of rice bran differed compared with those stated in previous reports, which was likely due to the difference in rice strains and extraction conditions used based on supercritical CO 2 extraction.…”

Section: Discussionsupporting

confidence: 91%

<i>In Vivo</i> Hair Growth-Promoting Effect of Rice Bran Extract Prepared by Supercritical Carbon Dioxide Fluid

Choi

Jeon²,

Moon³

et al. 2014

Biological & Pharmaceutical Bulletin

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The potential hair growth-promoting activity of rice bran supercritical CO 2 extract (RB-SCE) and major components of RB-SCE, linoleic acid, policosanol, γ-oryzanol, and γ-tocotrienol, were evaluated with the histological morphology and mRNA expression levels of cell growth factors using real-time reverse transcriptase-polymerase chain reaction (PCR) in C57BL/6 mice. RB-SCE showed hair growth-promoting potential to a similar extent as 3% minoxidil, showing that the hair follicles were induced to be in the anagen stage. The numbers of the hair follicles were significantly increased. In addition, mRNA expression levels of vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), and keratinocyte growth factor (KGF) were also significantly increased and that of transforming growth factor-β (TGF-β) decreased in RB-SCE-treated groups. Among the major components of RB-SCE, linoleic acid and γ-oryzanol induced the formation of hair follicles according to examination of histological morphology and mRNA expression levels of cell growth factors. In conclusion, our results demonstrate that RB-SCE, particularly linoleic acid and γ-oryzanol, promotes hair growth and suggests RB-SCE can be applied as hair loss treatment. Key words rice bran supercritical CO 2 extract; hair growth-promoting activity; in vivoAlthough hair loss is not a mortal disorder, it has a great impact on a person's self-respect, mental health, and overall quality of life. Approximately 50-60 hairs are normally lost per day, which does not have a noticeable effect on appearance; however, excess loss (>100) results in baldness. Androgenetic alopecia is the most common type of hair loss, affecting millions of both men and women.1) There are many causes of hair loss in men and women, including diseases, nutritional deficiency, aging, hormone imbalance, and stress. Androgenetic alopecia may occur as early as the teenage years, but typically begin in the later decades of life. 2,3) Hair loss affects at least half of all men by the age of 50 and up to 70% of 70-year-old men. 4)

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Section: Discussionsupporting

confidence: 91%

<i>In Vivo</i> Hair Growth-Promoting Effect of Rice Bran Extract Prepared by Supercritical Carbon Dioxide Fluid

Choi

Jeon²,

Moon³

et al. 2014

Biological & Pharmaceutical Bulletin

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“…Gamma-oryzanol, a group of ferulic acid esters of phytosterols, is a major phytochemical in rice bran oil. Among the ten components of gamma-oryzanol that have been isolated and identified from rice bran oil 3) , the four major components are cycloartenyl ferulate, 24-methylene cycloartanyl ferulate, b-sitosteryl ferulate and campesteryl ferulate 4) . The gamma-oryzanol exhibits antioxidant properties, including free radical scavenging 4,5) and lipoperoxidation prevention 5,6) .…”

Section: Introductionmentioning

confidence: 99%

Degradation Kinetics of Gamma-Oryzanol in Antioxidant-Stripped Rice Bran Oil during Thermal Oxidation

et al. 2009

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Gamma-oryzanol, a group of phytosterol ferulates found in rice bran, possesses antioxidative activity and other bioactivities. The kinetics of thermal degradation of gamma-oryzanol in stripped rice bran oil (SRBO) were investigated under heating at 132, 160, 192 and 222 for 480, 140, 60 and 50 h, respectively. Losses of the overall gamma-oryzanol and its components (cycloartenyl ferulate, 24-methylene cycloartanyl ferulate, campesteryl ferulate and b-sitosteryl ferulate) could be expressed by the first-order kinetics model. The rate constant of thermal degradation of gamma-oryzanol increased with increasing heating temperatures. The temperature dependence of the obtained rate constants was found to obey the Arrhenius equation. Campesteryl ferulate showed slightly more thermally resistant than other components at temperature lower than 160 . However, the change in the absorbance from 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay as a function of heating time exhibited the same pattern for the SRBO with and without gamma-oryzanol for all studied heating temperatures.

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“…The center rows in each experimental plot were harvested to observe grain yield. In addition, gamma oryzanol values from rice bran of 27 tested genotypes were also recorded by using high performance liquid chomatography (HPLC) method (Xu and Godber, 1999). Analysis of variance for individual locations and combined analysis of variances of 8 locations were performed by following the procedure described by Gomez and Gomez (1984).…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Black Glutinous Rice Genotypes for Stability of Gamma Oryzanol and Yield in Tropical Environments

Banterng¹,

Joralee²

2014

Turkish Journal of Field Crops

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Gamma oryzanol is an important phytochemical of black glutinous rice as it has positive effects on human health. The objective of this study was to evaluate stability of gamma oryzanol content and grain yield for black glutinous rice genotypes grown under different environments. Twenty-five black glutinous rice genotypes and 2 white glutinous rice genotypes were evaluated during 2011 and 2012 in 8 farmers' fields of Thailand. The experimental trials were laid out in a randomized complete blocks design (RCBD) with 3 replications. Soil data before growing, weather data during growing season, yield components, grain yield and gamma oryzanol content were recorded. The results indicated that location (L), genotype (G) and G×L interaction were highly significant for number of panicles per hill, number of filled grains per panicle, 1000-grain weight, grain yield, gamma oryzanol per grain weight and gamma oryzanol yield. The GGE biplot analysis indicated that KKU-GL-BL-06-023 (V17), Khaokam Gs.no. 88084 (V5) and KKU-GL-BL-11-001 (V25) had both high mean performance and stability for grain yield. The superior genotypes for gamma oryzanol per grain weight were KKU-GL-BL-11-001 (V25) and KKU-GL-BL-06-043 (V23). The desirable genotypes for gamma oryzanol yield were KKU-GL-BL-11-001 (V25), Niewdam Gs.no. 21427 (V3) and KKU-GL-BL-06-043 (V23).

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Purification and Identification of Components of γ-Oryzanol in Rice Bran Oil

Cited by 334 publications

References 9 publications

<i>In Vivo</i> Hair Growth-Promoting Effect of Rice Bran Extract Prepared by Supercritical Carbon Dioxide Fluid

<i>In Vivo</i> Hair Growth-Promoting Effect of Rice Bran Extract Prepared by Supercritical Carbon Dioxide Fluid

Degradation Kinetics of Gamma-Oryzanol in Antioxidant-Stripped Rice Bran Oil during Thermal Oxidation

Evaluation of Black Glutinous Rice Genotypes for Stability of Gamma Oryzanol and Yield in Tropical Environments

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