Purification and evaluation of 2, 4-di-tert butylphenol (DTBP) as a biocontrol agent against phyto-pathogenic fungi

Kushveer, J. S.; Sharma, Rahul; Samantaray, Mahesh; Amutha, R.; Sarma, V. Venkateswara

doi:10.1016/j.funbio.2023.05.002

Cited by 6 publications

(2 citation statements)

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“…2,4-DTBP is a lipophilic phenolic compound identified in various plants, and previous studies have highlighted its antifungal properties. − Our present study suggests the distinct inhibitory potential of different concentrations of 2,4-DTBP on R. solanacearum growth (Figure ).…”

Section: Discussionsupporting

confidence: 61%

“…2,4-DTBP is a lipophilic phenolic compound identified in various plants, and previous studies have highlighted its antifungal properties. 24 − 26 Our present study suggests the distinct inhibitory potential of different concentrations of 2,4-DTBP on R. solanacearum growth ( Figure 1 ). This inhibition can be succinctly illustrated by the cell viability, which was 76, 58, 53, and 35% at 0.1, 0.5, 1.0, and 2.0 mM 2,4-DTBP.…”

Section: Discussionsupporting

confidence: 50%

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Efficacy of 2,4-Di-tert-butylphenol in Reducing Ralstonia solanacearum Virulence: Insights into the Underlying Mechanisms

Yang,

Wang,

Lin

et al. 2024

ACS Omega

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Ralstonia solanacearum can induce severe wilt disease in vital crops. Therefore, there is an urgent need to develop novel antifungal solutions. The natural compound 2,4-di-tert-butylphenol (2,4-DTBP) exhibits diverse physiological activities and affects soil function. However, its specific impact on the R. solanacearum remains unclear. Here, we investigated the antimicrobial potential of 2,4-DTBP. The results demonstrated that 2,4-DTBP effectively inhibited its growth and altered morphology. In addition, it substantially impeded biofilm formation, motility, and exopolysaccharide secretion. Transcriptomic analysis revealed that 2,4-DTBP inhibited energy production and membrane transport. Additionally, 2,4-DTBP hindered the growth by interfering with the membrane permeability, reactive oxygen species (ROS) production, and electrolyte leakage. Concomitantly, this led to a significant reduction in pathogenicity, as evidenced by the biomass of R. solanacearum in the invaded roots. Overall, our data strongly support the potential utility of 2,4-DTBP as a potent antibacterial agent capable of effectively preventing the onset of bacterial wilt caused by R. solanacearum.

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