“…HE effects of changes in intracellular free calcium levels on nonmuscle cell motility, organelle movement, and cell morphology (2,10,20,21,35,45,53,55,81,82) appear to involve, in part, the activation of the calmodulin/myosin light chain kinase (CaM/MLCK) ~ complex (3,8,10,16,17,30,35,45,55,82,84) which catalyzes the stoichiometric phosphorylation of myosin light chains at specific sites (8,29,77). However, our knowledge about CaM/MLCK signal transduction complexes, how they are properly assembled, and how these supramolecular structures are able to selectively transduce calcium signals into cellular responses in nonmuscle cells is incomplete.…”