Pure Squamous Cell Carcinoma of the Breast Presenting as a Pyogenic Abscess: A Case Report

Nair, Vimoj; Kaushal, Vivek; Atri, Rajeev

doi:10.3816/cbc.2007.n.032

Cited by 20 publications

(21 citation statements)

References 11 publications

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“…MPSHK için tedavinin temelini modifiye radikal mastektomi oluşturmaktadır [9]. Diğer meme tümör-lerinin aksine aksiller metastaz %10-30 arasında görülmektedir [3].…”

Section: Discussionunclassified

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Primary squamous cell carcinoma of breast presenting with symptoms of breast abscess

Habibi

Ozener²,

Karakaş³

et al. 2015

J Clin Exp Invest

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Although breast abscess is a common inflammatory breast disease, there are rare cases that were found to be associated with malignancy. Primary squamous cell carcinoma of breast (PSCCB) is an example of this. Only a very limited number of PSCCB patients presented with an abscess are reported in the literature. Although rarely seen, postmenopausal women presented with symptoms of breast abscess and exhibiting a poor response to treatment, the possibility of (PSCCB) disease should always be considered in the differential diagnosis. J Clin Exp Invest 2015; 6 (3): 318-320 Key words: Abscess, breast, squamous cell carcinoma ÖZET Meme apsesi, memenin sık karşılaşılan enflamatuar bir hastalığı olmasına karşın nadiren de olsa altından malign özellikli durumlar çıkabilmektedir. Memenin primer skuamöz hücreli karsinomu (MPSHK) buna örnektir. Literatür-de apse ile prezente olan MPSHK oldukça sınırlı sayıda hastada bildirilmiştir. Nadir olarak görülmesine rağmen, meme apsesi belirtileri ile başvuran ve tedaviye zayıf yanıt gösteren postmenopozal kadınlarda MPSHK hastalığı olasılığı her zaman ayırıcı tanıda düşünülmelidir.

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“…MPSHK için tedavinin temelini modifiye radikal mastektomi oluşturmaktadır [9]. Diğer meme tümör-lerinin aksine aksiller metastaz %10-30 arasında görülmektedir [3].…”

Section: Discussionunclassified

“…Ancak tedavide kemoterapinin (KT) rolü ve etkinliği konusunda kısıtlı bilgi olduğun-dan aksiller diseksiyon mutlaka önerilmektedir [6]. Meme koruyucu cerrahi tedavi seçeneklerinin ise etkinliği ile ilgili bir çalışma yoktur [9]. Literatürde olgu serileri kısıtlı olduğundan KT rejimleri konusunda netlik yoktur.…”

Section: Discussionunclassified

Primary squamous cell carcinoma of breast presenting with symptoms of breast abscess

Habibi

Ozener²,

Karakaş³

et al. 2015

J Clin Exp Invest

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“…4 Although these tumors most frequently present like the usual breast carcinoma, SCC of the breast may, on very rare occasions, present as a breast abscess. 5 A systematic survey of indexed articles using the terms "epidermoid carcinoma of the breast" and "abscess" and using the terms "squamous cell carcinoma", "breast" were found in Medline ( Table 1). [5][6][7][8][9][10][11][12][13] A less specific survey using the terms "epidermoid carcinoma" and "breast (MeSH terms)" and using the terms "squamous cell carcinoma" and "breast (MeSH terms)" was also conducted.…”

Section: Discussionmentioning

confidence: 99%

“…5 A systematic survey of indexed articles using the terms "epidermoid carcinoma of the breast" and "abscess" and using the terms "squamous cell carcinoma", "breast" were found in Medline ( Table 1). [5][6][7][8][9][10][11][12][13] A less specific survey using the terms "epidermoid carcinoma" and "breast (MeSH terms)" and using the terms "squamous cell carcinoma" and "breast (MeSH terms)" was also conducted. However, this proved to be less productive, since only five articles written in English since 1980 could be found.…”

Section: Discussionmentioning

confidence: 99%

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Primary epidermoid carcinoma of the breast presenting as a breast abscess and sepsis

Damin¹,

Nascimento²,

Andreola³

et al. 2011

Sao Paulo Med. J.

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Primary epidermoid carcinoma of the breast presenting as a breast abscess and sepsisresUMo CONTEXTO: O carcinoma de células escamosas da mama é um câncer extremamente raro, representando cerca de 0,04% dos tumores malignos da mama. Até o momento, apenas um número limitado de casos da doença foi relatado, a maioria se apresentando clinicamente como um carcinoma de mama usual. RELATO DE CASO: Paciente feminina de 39 anos de idade se apresentando com grande abscesso de mama e sinais de sepse. Após debridamento cirúrgico da lesão, o exame histopatológico da cápsula do abscesso revelou a presença de carcinoma de células escamosas da mama. O tratamento definitivo do tumor foi uma mastectomia radical modificada com ressecção da lesão residual na mama direita. CONCLUSÃO: O presente caso, de apresentação incomum, demonstra como uma lesão aparentemente benigna, como um abscesso mamário, pode estar relacionada a uma neoplasia maligna oculta. Uma revisão da literatura a respeito do carcinoma de células escamosas de mama é apresentada.I MD, PhD. Attending Physician,

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Fine‐needle aspiration biopsy of an invasive ductal carcinoma with medullary features presented with abscess formation

Kelten

Türk

Kesen

et al. 2010

Diagnostic Cytopathology

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We point out that breast carcinomas infrequently appear as cystic masses, which may mimic an abscess formation clinically and cytologically. A 38-year-old woman was presented with a breast mass for 2 weeks. In her physical examination, a palpable, tender breast mass was found within the upper outer quadrant of the right breast without axillary lymphadenopathy. Mammography showed a suspicious microcalcified mass with slightly irregular margins (3 cm in diameter). An ultrasound of the breast revealed a cystic lesion with rough papillary projections. Fine-needle aspiration biopsies (FNABs) from solid and cystic areas of the mass were performed. The smears showed syncytial groups of atypical cells (nuclear pleomorphism, hyperchromasia, nuclear contour irregularity but no macronucleoli) in a background composed of prominent neutrophils and sparse plasma cells (Fig. 1). Tubular formation was also observed in some groups of tumor cells. A diagnosis of malignant cytology consistent with high-grade ductal carcinoma was rendered. The patient, then, underwent breast conservative surgery with sentinel lymph node dissection and was diagnosed as invasive ductal carcinoma with medullary features. No axillary lymph node metastasis was identified.Breast carcinomas are rarely seen clinically as cystic masses. 1 Cystic breast carcinomas comprise intracystic papillary carcinoma, solid tumors infiltrating benign cysts, or cystic degeneration of solid tumors. 1,2 FNABs from these lesions may reveal varying amounts of neutrophils, which may obscure the tumor cells and mimic abscess formation easily. Therefore, smears with abundant neutrophils in the background should be considered with caution.The differential diagnosis of a breast carcinoma from an abscess is important. Both breast carcinomas and abscess may cause skin retraction, erythema of breast skin, and tenderness. A carcinoma can occur in any site of the breast, whereas breast abscess mostly is confined to subareolar region with a previous history of multiple abscesses in the same area. Breast abscess may have sparse epithelial cells with regenerative atypia on FNAB. However, ultrasound-directed FNAB from breast mass may better reveal groups of many carcinoma cells.High-grade invasive ductal carcinomas with or without medullary features, medullary carcinomas, or pure squamous cell carcinomas have been reported as cystic degenerative masses with extensive neutrophils on their smears. 3-6 Akbulut et al. reported cytologic features in FNAB from 20 histologically verified medullary breast carcinomas. 4 Only 1 of these 20 cases appeared radiologically as a partly cystic, solid mass (as in our case) and the rest as solid circumscribed masses. However, the presence of neutrophils was observed in 11 of the 20 cases, 3 of which strongly suggested abscess formation. This may show that abundant neutrophils may exist in the background of smears even if the tumors include no cystic components. Moreover, not only a prominent lymphoplasmacytic background but also a neutrophilic infiltrate may...

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Pure Squamous Cell Carcinoma of the Breast Presenting as a Pyogenic Abscess: A Case Report

Cited by 20 publications

References 11 publications

Primary squamous cell carcinoma of breast presenting with symptoms of breast abscess

Primary squamous cell carcinoma of breast presenting with symptoms of breast abscess

Primary epidermoid carcinoma of the breast presenting as a breast abscess and sepsis

Fine‐needle aspiration biopsy of an invasive ductal carcinoma with medullary features presented with abscess formation

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