Pure red cell aplasia secondary to rheumatoid arthritis: a case report

Weerasinghe, Suneth; Karunathilake, Parackrama; Ralapanawa, Udaya; Jayalath, Thilak; Abeygunawardena, Shamali; Rathnayaka, Manel

doi:10.1186/s13256-021-03141-5

Cited by 2 publications

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References 28 publications

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“…In autoimmune hemolytic anemias side by side with hemolysis it may take place process of somatic cells fusion with further formation of tumor cells. [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Corelation Between Rheumatic Disease and Autohemolitic Anemia

Spasovski¹,

Sandevska²,

Balkanov³

et al. 2022

JMS

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The autoimmune hemolytic anemias antibody can be hot or cold, have an incidence of 70 to 80% may be idiopathic in 50 to 60% and the rest of the cases secondary to lymphoproliferative disorders, collagen disease, drugs, solid tumors, infections and inflammatory bowel disease.RA may result in the reduced lifespan of red blood cells. This could lead to anemia if the body is unable to produce new red blood cells at a sufficient rate. Understanding these links between RA and anemia is crucial.Anemia is a common comorbidity in individuals with rheumatoid arthritis (RA). In fact, anemia of the type characterized by low serum iron concentrations in conjunction with adequate iron stores is frequently associated with RA and has served as a model for anemia of chronic disease. Rheumatoid vasculitis can affect blood vessels in many parts of your body. For this reason, it can cause many different symptoms.It most often damages blood vessels to the skin, fingers and toes, nerves, eyes, and heart. This reduces blood flow to these areas and damages them.Rheumatoid arthritis (RA) may be associated with a range of extraarticular manifestations, with hematologic complications including anemia and other conditions with hematologic abnormalities, such as Felty syndrome and lymphoproliferative disorders, particularly lymphoma and large granular lymphocyte (LGL) leukemia.

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“…In autoimmune hemolytic anemias side by side with hemolysis it may take place process of somatic cells fusion with further formation of tumor cells. [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Corelation Between Rheumatic Disease and Autohemolitic Anemia

Spasovski¹,

Sandevska²,

Balkanov³

et al. 2022

JMS

View full text Add to dashboard Cite

show abstract

“… 8 Also, PRCA secondary to autoimmune disorders responds well to immunosuppression. 9 Thymomas are complicated by PRCA and the treatment of choice is resection. 10 The goal for PRCA management rests on attaining normal hemoglobin without requiring transfusion.…”

Section: Introductionmentioning

confidence: 99%

Pure Red Cell Aplasia Encountered in a Tertiary Care Hematology Laboratory: A Series of Nine Distinctive Cases

et al. 2022

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Pure red cell aplasia (PRCA) is characterized by severe anemia with reticulocytopenia and bone marrow erythroblastopenia. The early erythroblasts are markedly decreased; however, in rare instances, they may be normal or raised in number. There are varied etiologies, namely congenital or acquired and primary or secondary. The congenital PRCA is known as “Diamond-Blackfan anemia.” Thymomas, autoimmune disease, lymphomas, infections, and drugs also may be familiar associates. However, the etiologies of PRCA are numerous, and many diseases/infections can be associated with PRCA. The diagnosis rests on clinical suspicion and appropriate laboratory workup. We evaluated nine cases of red cell aplasia, having severe anemia with reticulocytopenia. Nearly half of the cases showed adequate erythroid (> 5% of the differential count) but with a maturation arrest. The adequacy of the erythroid could confuse the hematologist and may even delay the diagnosis. Hence, it is empirical that PRCA could be considered a differential in every case of severe anemia with reticulocytopenia, even in the presence of adequate erythroid precursors in the bone marrow.

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Pure red cell aplasia secondary to rheumatoid arthritis: a case report

Cited by 2 publications

References 28 publications

Corelation Between Rheumatic Disease and Autohemolitic Anemia

Corelation Between Rheumatic Disease and Autohemolitic Anemia

Pure Red Cell Aplasia Encountered in a Tertiary Care Hematology Laboratory: A Series of Nine Distinctive Cases

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