2021
DOI: 10.1093/rheumatology/keab363
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Pure red cell aplasia in systemic lupus erythematosus, a nationwide retrospective cohort and review of the literature

Abstract: Objectives To characterize the clinical and biological course, management and response to treatment in Systemic Lupus Erythematosus (SLE)-associated Pure Red Cell Aplasia (PRCA). Methods Nationwide multicentre retrospective cohort study. From 2006 to 2018, we included adults with a diagnosis of PRCA supported by bone-marrow examination and SLE or biologic manifestations of SLE after ruling out parvovirus B19 infection. … Show more

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Cited by 11 publications
(3 citation statements)
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“…In this case, our suspicions were based on her underlying autoimmune disease and past exposure to 2 types of rHuEPO (continuous erythropoietin receptor activator [CERA] and biosimilar erythropoietin alpha). PRCA is rare in patients with SLE [ 16 , 17 ]. A retrospective study [ 17 ] we performed January 2010 to December 2017 in our center showed that nearly 50% of the etiology was ESA-related PRCA.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In this case, our suspicions were based on her underlying autoimmune disease and past exposure to 2 types of rHuEPO (continuous erythropoietin receptor activator [CERA] and biosimilar erythropoietin alpha). PRCA is rare in patients with SLE [ 16 , 17 ]. A retrospective study [ 17 ] we performed January 2010 to December 2017 in our center showed that nearly 50% of the etiology was ESA-related PRCA.…”
Section: Discussionmentioning
confidence: 99%
“…The pathogenesis of PRCA in SLE is hypothesized to be related to autoantibody formation targeting erythroblasts, erythroidprogenitors, and erythropoietin [ 18 , 19 ]. From a recent retrospective cohort study [ 16 ], the treatment response rates to immunosuppressive drugs were 75%, 100%, 50%, 75%, 60% in azathioprine, cyclophosphamide, cyclosporin, mycophenolic acid, and rituximab, respectively. The reciprocating increase in Hb varied depending on the immunosuppressive regimen.…”
Section: Discussionmentioning
confidence: 99%
“…Many immunosuppressive drugs used after transplantation have potential myelosuppressive effects, and immunosuppressants such as tacrolimus and mycophenolate mofetil (MMF) have been reported to be a cause of PTA after kidney transplantation ( 108 ). Anemia has been reported to be more common in patients taking MMF and sirolimus ( 12 ).…”
Section: Status Of Interventions For Anemia In Kidney Transplant Reci...mentioning
confidence: 99%