Pure Red Cell Aplasia Associated With Sulphasalazine

Dunn, A.M.; Kerr, G. D.

doi:10.1016/s0140-6736(81)91523-3

Cited by 14 publications

(3 citation statements)

References 6 publications

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“…A review of literature revealed 6 cases of drugs induced pure red cell aplasia or aplastic anemia (including sulfasalazine, tripterygium wilfordii, and leflunomide). [5–8] The clinical data of these cases were summarized in Table 1. According to the literature, among the drugs used by this patient, sulfasalazine could induce acquired PRCA, [1,5,6,9] while tripterygium wilfordii and leflunomide could induce aplastic anemia (AA), which was associated with a drug-induced hematotoxic effect or T-cell-independent mechanism.…”

Section: Discussionmentioning

confidence: 99%

“…[5–8] The clinical data of these cases were summarized in Table 1. According to the literature, among the drugs used by this patient, sulfasalazine could induce acquired PRCA, [1,5,6,9] while tripterygium wilfordii and leflunomide could induce aplastic anemia (AA), which was associated with a drug-induced hematotoxic effect or T-cell-independent mechanism. [7,8,10] This patient had taken sulfasalazine (dosage unknown), tripterygium wilfordii tablets (48 μg/day) for 7 years.…”

Section: Discussionmentioning

confidence: 99%

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Acquired pure red cell aplasia in a patient with ankylosing spondylitis- a case report and literature review

et al. 2019

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Rationale: Acquired pure red cell aplasia (PRCA) can be a secondary response to some autoimmune disorders. However, there is no data about the possibility of acquired PRCA being a secondary complication to ankylosing spondylitis (AS). Patient concerns: A 42-year-old male who had a history of AS for 14 years. He got serious anemia 17 months ago. Bone marrow smear indicated PRCA. Diagnose: He was diagnosed with acquired PRCA secondary to AS. Intervention: The combination treatment of immunosuppressants with hematopoiesis stimuli was successful. Outcomes: The patient recovered from PRCA, and showed improvement in his AS. Lessons: Acquired PRCA can be secondary to AS. Cyclosporine is effective in controlling AS arthritis syndrome and in addition to immunosuppressants, promotion of erythroid hematopoiesis is equally important.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Acquired pure red cell aplasia in a patient with ankylosing spondylitis- a case report and literature review

et al. 2019

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“…Patients who are slow acetylators are also at increased risk for sulfasalazineinduced anemia [69]. In addition to the antimetabolite effect of drugs for IBD, mesalamine and sulfasalazine have been associated with rare cases of aplastic anemia, thrombocytopenia or neutropenia [70][71][72][73].…”

Section: Hematologic Consequences Of Intestinal Inflammationmentioning

confidence: 99%