1981
DOI: 10.1016/s0140-6736(81)91523-3
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Pure Red Cell Aplasia Associated With Sulphasalazine

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Cited by 14 publications
(3 citation statements)
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“…A review of literature revealed 6 cases of drugs induced pure red cell aplasia or aplastic anemia (including sulfasalazine, tripterygium wilfordii, and leflunomide). [5–8] The clinical data of these cases were summarized in Table 1. According to the literature, among the drugs used by this patient, sulfasalazine could induce acquired PRCA, [1,5,6,9] while tripterygium wilfordii and leflunomide could induce aplastic anemia (AA), which was associated with a drug-induced hematotoxic effect or T-cell-independent mechanism.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…A review of literature revealed 6 cases of drugs induced pure red cell aplasia or aplastic anemia (including sulfasalazine, tripterygium wilfordii, and leflunomide). [5–8] The clinical data of these cases were summarized in Table 1. According to the literature, among the drugs used by this patient, sulfasalazine could induce acquired PRCA, [1,5,6,9] while tripterygium wilfordii and leflunomide could induce aplastic anemia (AA), which was associated with a drug-induced hematotoxic effect or T-cell-independent mechanism.…”
Section: Discussionmentioning
confidence: 99%
“…[5–8] The clinical data of these cases were summarized in Table 1. According to the literature, among the drugs used by this patient, sulfasalazine could induce acquired PRCA, [1,5,6,9] while tripterygium wilfordii and leflunomide could induce aplastic anemia (AA), which was associated with a drug-induced hematotoxic effect or T-cell-independent mechanism. [7,8,10] This patient had taken sulfasalazine (dosage unknown), tripterygium wilfordii tablets (48 μg/day) for 7 years.…”
Section: Discussionmentioning
confidence: 99%
“…Patients who are slow acetylators are also at increased risk for sulfasalazineinduced anemia [69]. In addition to the antimetabolite effect of drugs for IBD, mesalamine and sulfasalazine have been associated with rare cases of aplastic anemia, thrombocytopenia or neutropenia [70][71][72][73].…”
Section: Hematologic Consequences Of Intestinal Inflammationmentioning
confidence: 99%