Pure Red Cell Aplasia

Krantz, Sanford B.; Zaentz, S. Donald

doi:10.1007/978-1-4899-6688-9_5

Cited by 37 publications

(36 citation statements)

References 92 publications

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“…PRCA is an isolated disorder of erythropoiesis that leads to a progressive, severe anemia of sudden onset (11). Due to an almost complete cessation of red blood cell (RBC) production the blood reticulocyte count is very low (Ͻ10,000/mm 3 ).…”

Section: Pure Red Cell Aplasia: a Rare Hematological Diseasementioning

confidence: 99%

Anti-Erythropoietin Antibodies and Pure Red Cell Aplasia

Rossert¹,

Casadevall²,

Eckardt³

2004

Journal of the American Society of Nephrology

129

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Section: Pure Red Cell Aplasia: a Rare Hematological Diseasementioning

confidence: 99%

Anti-Erythropoietin Antibodies and Pure Red Cell Aplasia

Rossert¹,

Casadevall²,

Eckardt³

2004

Journal of the American Society of Nephrology

129

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“…PRCA is an isolated disorder of erythropoiesis that leads to a progressively developing, severe, isolated anemia with sudden onset (7). Some factors are known to be associated with PRCA, but in approximately half of the cases, PRCA does not have an identifiable cause and is classified as idiopathic.…”

mentioning

confidence: 99%

Epoetin-Induced Autoimmune Pure Red Cell Aplasia

Casadevall

Eckardt

Rossert

2005

Journal of the American Society of Nephrology

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During the first 10 yr of therapy with recombinant human erythropoietin ([EPO]), only three cases of antibody-associated pure red cell aplasia have been described in patients who were treated with EPO, whereas several millions of patients have received this treatment. Thus, the possibility for epoetin to induce the formation of anti-EPO antibodies was considered extremely low. However, since 1998, a significant increase in the number of cases of EPO-induced pure red cell aplasia has been found in patients with chronic kidney disease with a peak in 2001 and 2002. The incidence rate seems now to be back to the baseline level. The change in formulation of epoetin ␣ sold outside the United States seems to be the cause of these antibodies.

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“…It can be either idiopathic or associated with thymoma, lymphoid malignancy, systemic lupus erythematosus, rheumatoid arthritis, viral infections (parvovirus B19, hepatitis B virus) or drugs (4). Pure red cell aplasia is usually an autoimmune disorder in which immunoglobulin IgG or cytotoxic T lymphocytes are directed against erythroid progenitors or precursors.…”

Section: Discussionmentioning

confidence: 99%

Recovery from Pure Red Cell Aplasia Caused by Anti Erythropoietin Antibodies After Kidney Transplantation

Snanoudj

Beaudreuil

Arzouk

et al. 2004

American Journal of Transplantation

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The use of recombinant human erythropoietin (rHuEPO) is a major advance in the treatment of patients with anemia caused by chronic renal failure (CRF). The development of antierythropoietin (anti-EPO) antibodies following treatment with rHuEPO has been observed in an increasing number of patients. This causes pure red cell aplasia (PRCA) and requires the definitive withdrawal of rHuEPO. Many patients require immunosuppressive therapy before anti-EPO antibodies disappear completely. We report a case of PRCA owing to anti-EPO in a 20-year-old hemodialyzed man who was receiving immunosuppressive therapy for a liver transplantation carried out in childhood. He required repeated red cell transfusions until a kidney transplantation was performed. He received an induction therapy with antithymocyte globulins and a maintenance regimen consisting of steroids, tacrolimus and mycophenolate mofetil. This new immunosuppressive treatment led to the complete disappearance of anti-EPO antibodies within a few weeks after the kidney transplantation. Erythropoiesis and endogenous erythropoietin synthesis were restored following transplantation, without leading to an increase in the titer of anti-EPO antibodies.

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Pure Red Cell Aplasia

Cited by 37 publications

References 92 publications

Anti-Erythropoietin Antibodies and Pure Red Cell Aplasia

Anti-Erythropoietin Antibodies and Pure Red Cell Aplasia

Epoetin-Induced Autoimmune Pure Red Cell Aplasia

Recovery from Pure Red Cell Aplasia Caused by Anti Erythropoietin Antibodies After Kidney Transplantation

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