Pure malignant rhabdoid tumor of the left kidney in an adult: A case report and review of the literature

Zhao, Guangning; Ren, Na; Yang, Yuming; Han, Rong

doi:10.3892/ol.2013.1207

Cited by 10 publications

(7 citation statements)

References 19 publications

(21 reference statements)

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“…Inhibiting fibroblastic growth factor receptors (FGFRs) has been recommended as a novel therapy for malignant rhabdoid tumors (MRTs) [12]. Targeting cell cycle, epigenetic genes, or specifically the molecular profiles of tumor subset may also help in the treatment of rhabdoid tumors (RTs) [13]. Specifically, the treatment of RTK consists of radical nephrectomy along with the resection of surrounding lymph nodes followed by chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Co-existent Rhabdoid Tumor of The Kidney and Brain in a Male Infant: A Rare Case

Tahir

Majid

Abbas

et al. 2019

Cureus

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Malignant rhabdoid tumor of the kidney (MRTK) is a rare neoplasm of infancy. We report a case of a nine-month-old male infant who presented to the pediatrics outpatient department with the history of fever, lethargy, and abnormal head movements. On gross examination, the patient had a firm, non-tender, intra-abdominal mass at the right lumbar region with irregular margins. Computed tomography scan of the abdomen revealed a lobulated soft tissue arising from the kidney with areas of necrosis. Brain magnetic resonance imaging was also performed, which showed a large heterogeneous lesion in the posterior fossa. Histopathologic study revealed loss of INI1 protein. Since MRTK and atypical teratoid rhabdoid tumor (ATRT) of the brain share a common mutation in the gene (hSNF5/INI1), hence a diagnosis of MRTK with co-existent ATRT of the brain was established. Actinomycin-D and vincristine failed to show any improvement and the condition of the patient deteriorated progressively, resulting in his death within 15 days of hospital admission.

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Section: Discussionmentioning

confidence: 99%

Co-existent Rhabdoid Tumor of The Kidney and Brain in a Male Infant: A Rare Case

Tahir

Majid

Abbas

et al. 2019

Cureus

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“…RTK is traditionally diagnosed by the presence of a mass in the abdomen along with urinary hesitancy (Amar, Tomlinson, Green, Breslow, & de Alarcon, ; Zhao, Na, Yang, & Han, ; Table ). Imaging diagnosis for RTK can be difficult due to its high similarity with other renal tumors, especially nephroblastoma.…”

Section: Rhabdoid Tumor Of Kidney: Most Lethal Pediatric Renal Malignmentioning

confidence: 99%

Lessons learned from the developmental origins of childhood renal cancer

Chong

Cain

2019

The Anatomical Record

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Despite the rarity of renal tumors in children, many different types of malignant and nonmalignant renal neoplasms have been described. Therefore, the correct diagnosis and clinical management of these patients can represent a challenge. Here we provide a comprehensive review of the commonly diagnosed pediatric renal malignancies, including nephroblastoma (commonly known as Wilms tumor), clear cell sarcoma of the kidney, rhabdoid tumor of the kidney, several subtypes of renal cell tumors (often collectively termed renal cell carcinoma), and congenital mesoblastic nephroma. The epidemiology, pathology, treatments, underlying genetic and molecular mechanisms, and proposed developmental origins are discussed in detail, highlighting differential features and potential improved therapeutic strategies for affected individuals.

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“…Malignant rhabdoid tumours (MRTs) of the kidney are rare tumours that occur mainly in children (1). Cases of adult patients with renal MRT are extremely rare, with <20 such cases reported in the literature to date (2)(3)(4)(5). The hSNF/INI1/SMARCB1/BAF47 gene is hypothesized to act as a suppressor gene, and INI1 is expressed in normal cells throughout the body (6).…”

Section: Introductionmentioning

confidence: 99%

Malignant rhabdoid tumour in an adult kidney: A case report

et al. 2019

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Malignant rhabdoid tumours (MRTs) in the kidney are rare paediatric tumours that are extremely rare in adults. We herein report the case of an adult patient with a renal MRT. A 79-year-old Japanese woman was found to have a tumour sized 63x48 mm in the left kidney, in addition to multiple metastatic bone and lymph node lesions. The needle biopsy specimen obtained from the patient's kidney revealed tumour cells with rhabdoid characteristics: The cells appeared large, round or polygonal, with eccentrically located nuclei and prominent nucleoli. Immunohistochemically, the tumour cells were positive for vimentin, epithelial membrane antigen, CAM 5.2, and p53, and negative for INI1, cytokeratin (CK)7, CK20, α-methylacyl-CoA racemase, S100, CD45, renal cell carcinoma marker, anaplastic lymphoma kinase, α-smooth muscle actin, desmin, MyoD, myogenin, human melanoma black 45 and melan A. Therefore, the tumour was diagnosed as an MRT located in the kidney. Although the patient was treated with axitinib, a tyrosine kinase inhibitor, the renal tumour and its metastatic lesions continued to progress, and the number of metastatic lesions increased. The patient succumbed to the disease 5 months after the first hospital visit. The disease progression was rapid, with a poor prognosis, consistently with previous reports that of MRTs in the adult kidney.

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Pure malignant rhabdoid tumor of the left kidney in an adult: A case report and review of the literature

Cited by 10 publications

References 19 publications

Co-existent Rhabdoid Tumor of The Kidney and Brain in a Male Infant: A Rare Case

Co-existent Rhabdoid Tumor of The Kidney and Brain in a Male Infant: A Rare Case

Lessons learned from the developmental origins of childhood renal cancer

Malignant rhabdoid tumour in an adult kidney: A case report

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