Pure intraventricular origin of gliosarcoma – a rare entity

Abstract

Gliosarcomas (GS) are high grade, rare tumours. Radiologically they are seen as a surfacing lesion, often having a thick dural attachment located within the parenchyma of the brain. We report a very unusual case of an intraventricular non-parenchyhmal gliosarcoma in a 60-yearold female. Magnetic resonance imaging of the brain revealed a well defined brilliantly enhancing mass located in the septal region and extending into the body and the frontal horn of the lateral ventricle on either side. The mass was isointense on T1-weighted sequences and hypointense on T2-weighted sequences. Very few reports that describe this entity exist and our case report adds to the sparse literature.KeywoRds: Gliosarcoma, Intraventricular, Non parenchymal ÖZ Gliosarkomlar (GS) yüksek dereceli, nadir tümörlerdir. Radyolojik olarak sıklıkla beyin parankiminde bulunan kalın dural bir tutulma kısmıyla yüzeye çıkan bir lezyon olarak görülürler. Burada 60 yaşında bir kadında intraventriküler nonparenkimal gliosarkom şeklinde çok nadir bir vakayı sunuyoruz. Beynin manyetik rezonans görüntülemesi septal bölgede çok parlak şekilde kontrast madde tutan iyi tanımlanmış bir kitleyi ve her iki tarafta lateral ventrikülün frontal kornusu ve gövdesine uzanmasını gösterdi. Kitle T1 ağırlıklı dizilerde izointens ve T2-ağırlıklı dizilerde hipointensti. Bu varlığı tanımlayan çok az sayıda rapor vardır ve vaka raporumuz bu az sayıda yayına katkıda bulunmaktadır.

Primary intraventricular gliosarcoma on MRI: A challenging diagnosis

“…Generally, GS is located in the area of the cerebral hemisphere, involving the temporal, frontal, parietal, or occipital lobes [8] . Intraventricular GS is extremely rare and is typically found in the lateral ventricle and septum pellucidum [1] , and three cases of GS in the septum pellucidum have been reported [ 8 , 14 , 15 ]. In our case, the neoplasm appeared at the trigone of the right lateral ventricle.…”

Intraventricular gliosarcoma with dual sarcomatous differentiation: A unique case

“…Radiologically, two patterns have been described: a peripherally located lesion involving the cortex associated with dural thickening and a central location with transependymal infiltration into the ventricles with 67% of primary and all secondary gliosarcomas being peripherally situated . Intraventricular location is uncommon to primary gliosarcoma and only a few cases have been documented . In a series of 15 cases of gliosarcoma, two were found to be intraventricular in location …”

“…16 Intraventricular location is uncommon to primary gliosarcoma and only a few cases have been documented. [12][13][14][15] In a series of 15 cases of gliosarcoma, two were found to be intraventricular in location. 14 Presence of heterologous elements in gliosarcoma is an uncommon phenomenon.…”

“…Unusual sites of origin, such as the lateral ventricles, have been documented. [12][13][14][15] Here, we describe a unique case of intraventricular gliosarcoma with a bi-sarcomatous, that is, liposarcomatous and myosarcomatous differentiation.…”

“…Gliosarcomas are intraparenchymal and often surfacing and abutting the meninges. Unusual sites of origin, such as the lateral ventricles, have been documented …”