Pure ground-glass nodules: are they really indolent?

Morphologic characteristics of pulmonary adenocarcinomas manifesting as pure ground-glass nodules on CT

“…They discuss the applicability of those parameters and their current limitations with respect to clinical practice (2). Both, Milanese et al and Cohen et al confirm our opinion that in the assessment of pure GGNs on a single CT scan, two dimensional CT size, as recommended by current guidelines (6)(7)(8), may be sufficient for clinical risk estimation (1,2). They also confirm that more sophisticated parameters such as volume, density, and roundness may play a lesser role (1,2).…”

“…This aspect of our findings, thus, has immediate practical implications. However, future longitudinal follow-up studies with these parameters investigated will show if they can provide useful incremental information with regard to prognosis and outcome (1,2).…”