Pure erythroid leukaemia with leukaemic cells mimicking myeloma cells

Morales‐Camacho, Rosario M.; Martín-Noya, Antonio

doi:10.1111/j.1365-2141.2008.07015.x

Cited by 5 publications

(5 citation statements)

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“…Liu et al (4) also reported that the median overall survival of 18 PEL patients was three months and that all patients died within seven months. Three PEL patients in other reports died at one, one and five months after admission (6)(7)(8). Thus, PEL has an extremely aggressive clinical course and a poor prognosis regardless of the association with HPS.…”

Section: Discussionmentioning

confidence: 92%

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Therapy-Related Pure Erythroid Leukemia with Hepatic Infiltration and Hemophagocytic Syndrome

et al. 2011

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Pure erythroid leukemia (PEL) is an extremely rare disorder characterized by neoplastic proliferation of immature erythroblasts. A 66-year-old man, who had received chemoradiotherapy for hypopharyngeal cancer, was admitted because of pancytopenia. Bone marrow was infiltrated with 81% proerythroblasts positive for CD71 and CD235a. An increased number of macrophages with active hemophagocytosis was also present. Chromosome analysis showed hypodiploid complex abnormalities. The patient died of progressive disease despite induction chemotherapy. Erythroblastic infiltration into the liver and hemophagocytosis in the spleen were found at autopsy. Therapy-related PEL with hemophagocytic syndrome and hepatic infiltration of PEL has never been reported.

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Section: Discussionmentioning

confidence: 92%

“…PEL is extremely rare and accounts for only 3 to 7% of AEL (2)(3)(4). Thus, there have been only a few reports describing its clinicopathological features in detail since the establishment of the PEL criteria (4)(5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Therapy-Related Pure Erythroid Leukemia with Hepatic Infiltration and Hemophagocytic Syndrome

et al. 2011

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“…The mature 'Marshalko-type', with their eccentric nuclei, condensed clock-face chromatin, deep blue cytoplasm, and perinuclear hoff, closely resemble basophilic erythroblasts, whereas the plasmablastic myeloma cells can be virtually indistinguishable from proerythroblasts. PEL developing as t-MN in patients treated for MM is very unusual [9]. The distinction of a PEL-morphology from MM can be challenging, particularly in cases where the neoplastic plasma cells have a blastic morphology, or when the MM progresses from a lowgrade to a high-grade neoplasm [9,15,16].…”

Section: Discussionmentioning

confidence: 99%

“…PEL developing as t-MN in patients treated for MM is very unusual [9]. The distinction of a PEL-morphology from MM can be challenging, particularly in cases where the neoplastic plasma cells have a blastic morphology, or when the MM progresses from a lowgrade to a high-grade neoplasm [9,15,16]. In such instances demonstration of erythroid lineage can be facilitated by immunohistochemistry.…”

Section: Discussionmentioning

confidence: 99%

“…The rarity of PEL coupled with the lack of erythroid-lineage-specific markers, frequent occurrence of early myeloid antigens on erythroid precursors, and an undifferentiated morphology makes distinction from minimally differentiated AML (M0) challenging. The very immature or early erythroid precursors may resemble immature cells of other hematopoietic lineages including plasmablasts/immature plasma cells [9], large cell lymphoma cells, and megakaryoblasts, as well as undifferentiated carcinoma cells. An awareness of the relationship of PEL to other entities that show morphological and immunophenotypic overlap with it is required for accurate diagnosis of PEL.…”

Section: Introductionmentioning

confidence: 99%

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The Diagnostic Challenge of Therapy-Related Pure Erythroid Leukemia Arising in the Setting of Multiple Myeloma

Evans¹,

Singh

Badros³

et al. 2014

J Leuk

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We report two interesting cases of patients with multiple myeloma, who developed a therapy-related myeloid neoplasm in the form of pure erythroid leukemia. In both cases, it was difficult to differentiate the erythroid blasts from plasma blasts by morphology alone. The diagnostic picture was further confounded by the presence of a hyperdiploid karyotype (case 1), which is a frequent cytogenetic abnormality in multiple myeloma but distinctly uncommon in acute myeloid leukemia. These cases highlight the diagnostic challenge encountered with pure erythroid leukemia in the setting of multiple myeloma, and underscore the importance of immunohistochemistry, cytogenetics, and gene rearrangement studies in resolving the diagnostic conundrum. To the best of our knowledge pure erythroid leukemia with a hyperdiploid karyotype arising in a background of pre-existing multiple myeloma, has not previously been reported.

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Acute Myeloid Leukaemia

2014

Morphology of Blood Disorders

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Pure erythroid leukaemia with leukaemic cells mimicking myeloma cells

Cited by 5 publications

References 0 publications

Therapy-Related Pure Erythroid Leukemia with Hepatic Infiltration and Hemophagocytic Syndrome

Therapy-Related Pure Erythroid Leukemia with Hepatic Infiltration and Hemophagocytic Syndrome

The Diagnostic Challenge of Therapy-Related Pure Erythroid Leukemia Arising in the Setting of Multiple Myeloma

Acute Myeloid Leukaemia

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