Pure eccentric exercise does not activate blood coagulation

Abstract

Eccentric exercise can cause skeletal muscle damage with ultrastructural disruption, inflammation and increased proteolytic enzyme activity. It may be possible that these changes are able to trigger blood coagulation in vivo. The aim of the study was to investigate changes in blood coagulation via the measurement of aPTT, the thrombin potential (total [TTP] and endogenous [ETP], both intrinsic [in] and extrinsic [ex]) and the thrombin generation (prothrombinfragment 1 + 2 [F1 + 2] and thrombin-antithrombin complex [TAT]) after pure eccentric exercise. Seventeen healthy non-smokers (28 +/- 6 years, VO2-peak 59 +/- 7 ml/min/kg) underwent pure eccentric down jumps (9 x 28 isolated down jumps in 90 min, drop from a height of 55 cm), a cycle exercise (90% of the individual anaerobic threshold for 60-90 min) and a control experiment on different days. Blood samples were drawn after a 30-min rest, immediately, and 2 h after exercise. After the cycle exercise, a clear shortening by 12% (P<0.001) in aPTT and an increase in TTPin (13%; P<0.05) and TAT (33%; P<0.05) in comparison to the control experiment were seen, while after eccentric exercise only minimal changes in aPTT and thrombin potential (TTPin, ETPin) and no thrombin generation (F1 + 2 and TAT) were found. In contrast to concentric dynamic exercise, e.g. cycle ergometry, only insignificant changes in thrombin potential and no thrombin generation could be observed after skeletal muscle damage induced by pure eccentric exercise. It can be concluded that the mechanical impact associated with eccentric exercise does not activate blood coagulation.

Effects of low‐intensity resistance exercise with blood flow restriction on coagulation system in healthy subjects

“…Exercise-induced thrombin generation seems to be a complex function of exercise type (Hilberg et al, 2005), intensity (Weiss et al, 1998) and duration (Mockel et al, 2001;Hilberg et al, 2003b). It has been considered that metabolic and ⁄ or adrenergic factors play some roles in exercise-induced thrombin generation, though the precise mechanism remains unclear.…”

“…Exercise‐induced thrombin generation seems to be a complex function of exercise type (Hilberg et al. , 2005), intensity (Weiss et al.…”

The comparing of acute effects of two training models aerobic and resistance on the clotting times in young women students

“…The results showed that the aerobic or anaerobic exercise have the same effect on the aPTT time and both of them led to a significant decrease in aPTT volatile and rise above the level of the ground state, is in a recovery. Hilberg et al [13] showed aPTT time to jump from a height of 55 cm deep extroverted than 90 minutes of exercise at 90% lactate threshold is much less reduced on a stationary bicycle pedal stronger stimulus to increase Thrombin is potential. Menzel and Hilberg [5] aPTT significant shortening of average activity with 80% of the anaerobic threshold in young men and the elderly were fixed.…”

Effects of physical activity on some of hemostatic parameters changes in epiphysectomized rats

“…Several studies have shown that strenuous exercise leads to a shortening of the activated partial thromboplastin time, and results in an increase of thrombin generation markers (Hilberg et al, 2005).…”