Pupillographic Evaluation of the Time Course of Atropine Effects in the Mouse Eye

Abstract

Atropine caused a longlasting suppression of the pupil responses in the mouse eye. That the duration of recovery was not obviously dose-dependent suggests that all doses used in this study were saturating the receptors in the iris musculature.

Spontaneous Axial Myopia and Emmetropization in a Strain of Wild-Type Guinea Pig (Cavia porcellus)

“…The continuous pupil trace was analyzed for pupil constriction amplitude and latency, as previously described for mouse measurements. 18 Measurements of Ocular Dimensions. Corneal curvature was measured in alert guinea pigs with a keratometer (OM-4; Topcon, Tokyo, Japan) mounted with a ϩ20 D aspherical lens, as described, 19 immediately after the refraction measurement.…”

Test systems for measuring ocular parameters and visual function in mice

“…22). Since the pupil of the mouse is detected and tracked during infrared photorefraction (Figure 1), it is easy to also use this technique for online analyses of pupil responses (23). For example, the effect of a single atropine eye drop on the mouse pupil was studied.…”

Parasympathetic control of the pupillary light response in the red‐eared slider turtle (Pseudemys scripta elegans)

“…Drugs can be topically applied to the cornea and allowed to diffuse to the iris, so that the receptor subtype bound by acetylcholine can be identified. In mammals, cholinergic drugs that interfere with pupil constriction are the muscarinic type 5–7 . In birds, interference by cholinergic drugs shows that acetylcholine instead acts primarily at nicotinic receptors to generate constriction 8–11 .…”

“…In mammals, cholinergic drugs that interfere with pupil constriction are the muscarinic type. [5][6][7] In birds, interference by cholinergic drugs shows that acetylcholine instead acts primarily at nicotinic receptors to generate constriction. [8][9][10][11] The difference is thought to be due to the type of musculature comprising the sphincter pupillae.…”