Pupillary Dilatation with Single Eyedrop Mydriatic Combinations

A randomized controlled trial to determine the lowest effective dose for adequate mydriasis in premature infants

“…Several studies in adults, in which the authors compared different doses of combination eye drops and single eye drops, have produced effective pupillary dilation but found that these results were confounded by age, sex, and iris color of the patients. 8,9 Our findings suggest that in this population, pupil dilation is not affected by age and gender.…”

Efficacy Of Topical Tropicamide 1% Versus Combination Of Tropicamide 0.8% And Phenylephrine 5% For Mydriasis

“…Our method was similar to studies done by many researchers who used either eye of the patients as controls. [3,9,15] This study has established that the fixed drug combination of 0.8% tropicamide with 5% phenylephrine is a better mydriatic than I% tropicamide alone, with a statistically significant difference between the two groups. A further pairwise analysis showed the difference to be significant at 30 and 45 minutes after instillation of the drops.…”

“…Minimal ocular and systemic side effects. [15,16] The commonly used drugs these days for mydriasis are tropicamide, which is a parasympatholytic and phenylephrine, a sympathomimetic. A combination of both these drugs is known to produce maximal mydriasis due to synergistic action of both classes of drugs.…”

Cycloplegic and mydriatic agents for routine ophthalmologic examination: a survey of pediatric ophthalmologists

“…Previous administration of proparacaine also appears to enhance pupillary dilation, probably by decreasing reflex tearing and blepharospasm and by increasing corneal permeability. 5,6 In rare cases, hypersensitivity to proparacaine has been associated with keratitis and iritis. 7 Because no single available agent is ideal, multiple drugs are often used, either sequentially or in mixture.…”