Pupil evaluation in addition to Glasgow Coma Scale components in prediction of traumatic brain injury and mortality (<i>Br J Surg</i> 2012; 99(Suppl 1): 122–130)

Stahel, Philip F.

doi:10.1002/bjs.7709

Cited by 7 publications

(3 citation statements)

References 8 publications

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“…Pupillometry has become standard of care in many ICUs due to its accuracy in evaluation and predicting outcome [13]. Using pupillary reactivity in combination with individual motor response has proved to outweigh the full GCS in predicting outcome [14]. In the subacute phase, a structured neurological examination can determine prognosis and identify patients who can benefit from neurorehabilitation.…”

Section: Clinical Evaluation Of Neurocritical Ill Patientsmentioning

confidence: 99%

Mastering the brain in critical conditions: an update

Robba,

Zanier,

Lopez Soto

et al. 2024

ICMx

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Acute brain injuries, such as traumatic brain injury and ischemic and hemorragic stroke, are a leading cause of death and disability worldwide. While characterized by clearly distict primary events—vascular damage in strokes and biomechanical damage in traumatic brain injuries—they share common secondary injury mechanisms influencing long-term outcomes. Growing evidence suggests that a more personalized approach to optimize energy substrate delivery to the injured brain and prognosticate towards families could be beneficial. In this context, continuous invasive and/or non-invasive neuromonitoring, together with clinical evaluation and neuroimaging to support strategies that optimize cerebral blood flow and metabolic delivery, as well as approaches to neuroprognostication are gaining interest. Recently, the European Society of Intensive Care Medicine organized a 2-day course focused on a practical case-based clinical approach of acute brain-injured patients in different scenarios and on future perspectives to advance the management of this population. The aim of this manuscript is to update clinicians dealing with acute brain injured patients in the intensive care unit, describing current knowledge and clinical practice based on the insights presented during this course.

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Section: Clinical Evaluation Of Neurocritical Ill Patientsmentioning

confidence: 99%

Mastering the brain in critical conditions: an update

Robba,

Zanier,

Lopez Soto

et al. 2024

ICMx

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“…Data related to patient baseline demographic and clinical characteristics extracted from medical records, including age, sex, smoking history, alcohol consumption history, past medical history, cause of injury, pupil parameters, and body mass index (BMI), etc. Pupil evaluation was referred to the previous literature (Supplementary Table 1) (6,12,13). Pupil reactivity was coded into three subgroups: (1) brisk (both pupils constricted identically with light shone into either eye alone); ( 2) sluggish (delayed pupil constriction in reaction to light); ( 3) fixed (no response to a light stimulus, regardless of which eye was being stimulated).…”

Section: Collection Of Clinical and Radiological Informationmentioning

confidence: 99%

“…Our study analyzed potential pyroptosis-related genes in TBI, which laid the foundation for subsequent clinical study. The Glasgow Coma Scale (GCS), pupil parameters and Helsinki CT score are often used to describe brain injury and evaluate its prognosis (6,7). The pathophysiological process secondary to trauma is important and complex, and many molecules are involved to influence the progression and outcome of the disease.…”

Section: Introductionmentioning

confidence: 99%

Nrf2 functions as a pyroptosis-related mediator in traumatic brain injury and is correlated with cytokines and disease severity: a bioinformatics analysis and retrospective clinical study

Zhao,

Lang

et al. 2024

Front. Neurol.

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BackgroundTraumatic brain injury (TBI) is a serious hazard to human health. Evidence has accumulated that pyroptosis plays an important role in brain trauma. The aim of this study is to screen potential key molecules between TBI and pyroptosis, and further explore their relationships with disease severity and cytokines.MethodsTo acquire differentially expressed genes (DEGs) before and after brain injury, the GSE89866 dataset was downloaded from the Gene Expression Omnibus (GEO) database. Meanwhile, pyroptosis-related genes were obtained from the GeneCards database, and the intersected genes were identified as differentially expressed pyroptosis-related genes (DEPGs). Moreover, the hub genes were screened via four algorithms (namely Maximum Clique Centrality, Edge Percolated Component, BottleNeck and EcCentricity) in Cytoscape software. Blood levels of Nrf2 were measured by ELISA using a commercially available kit. Finally, we further investigated the correlation between Nrf2 levels and medical indicators in TBI such as clinical characteristics, inflammatory cytokines, and severity.ResultsAltogether, we found 1,795 DEGs in GSE89866 and 98 pyroptosis-related genes in the GeneCards database. Subsequently, four hub genes were obtained, and NFE2L2 was adopted for further clinical study. By using Kruskal-Wallis test and Spearman correlation test, we found that the serum Nrf2 levels in severe TBI patients were negatively correlated with GCS scores. On the contrary, there was a positive correlation between serum Nrf2 levels and pupil parameters, Helsinki CT scores, IL-1 β and IL-18.ConclusionsIn summary, bioinformatic analyses showed NFE2L2 plays a significant role in the pathology of TBI. The clinical research indicated the increase in serum Nrf2 levels was closely related to the severity of trauma and cytokines. We speculate that serum Nrf2 may serve as a promising biochemical marker for the assessment of TBI in clinical practice.

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Closed Head Injury

Stahel

Flierl

2013

Management of Musculoskeletal Injuries in the Trauma Patient

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Pupil evaluation in addition to Glasgow Coma Scale components in prediction of traumatic brain injury and mortality (Br J Surg 2012; 99(Suppl 1): 122–130)

Cited by 7 publications

References 8 publications

Mastering the brain in critical conditions: an update

Mastering the brain in critical conditions: an update

Nrf2 functions as a pyroptosis-related mediator in traumatic brain injury and is correlated with cytokines and disease severity: a bioinformatics analysis and retrospective clinical study

Closed Head Injury

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