Punicic acid: A striking health substance to combat metabolic syndromes in humans

Shabbir, Muhmmad Asim; Khan, Moazzam Rafiq; Saeed, Muhammad; Pasha, Imran; Khalil, Anees Ahmed; Siraj, Naila

doi:10.1186/s12944-017-0489-3

Cited by 61 publications

(43 citation statements)

References 67 publications

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“…Canola oil showed the higher IP values as compared to sunfl ower oil possibly because of higher PUFA contents that play antioxidant role. Results indicate the strong antioxidant effect of PSO against oxidative deterioration due to its β-sitosterol, campesterol, stigmasterol, tocopherols, and PUFA contents as compared to synthetic antioxidants (SHABBIR et al, 2017). Similar results were observed by RAFIEE and co-workers (2012) while evaluating the protective effect of olive oil leaves extract in sunfl ower oil during storage.…”

Section: Statistical Studysupporting

confidence: 83%

Preventing oxidation of canola and sunflower oils by addition of pomegranate seed oil

et al. 2019

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The study was designed to explore the antioxidative effect of pomegranate seed oil (PSO) at different concentrations (5 and 7%) against oxidation of plant-based oils (canola oil and sunfl ower oil) during storage (60 days) as compared to artifi cial antioxidant butylated hydroxyanisole (BHA, 200 ppm). Rancimat and Schaal oven analysis were employed for the assessment of potential consequences of PSO against oxidation in plant based oils. The variation in total phenolic contents (TPC), antioxidant activity, peroxide value (POV), and tocopherol contents during storage were evaluated by Schaal oven test at 62 °C. The substantially (P≤0.05) higher induction period (IP) values were observed for PSO blended oil samples as compared to blank oil samples. The addition of PSO in plant-based oils improved the oxidative stability by enhancing the antioxidant potential and TPC, decreasing POV, and slowing down the degradation of tocopherol contents during storage. The fi ndings of the present study suggest that PSO might be used as an alternative potential antioxidant to synthetic antioxidants.

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Section: Statistical Studysupporting

confidence: 83%

Preventing oxidation of canola and sunflower oils by addition of pomegranate seed oil

et al. 2019

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“…The main mechanisms by which fresh PGJ affects the diabetic conditions, particularly insulin resistance ones, is by neutralizing the accumulated reactive oxygen species (ROS) such as O 2 · − , H 2 O 2 , and ·OH, and ultimately reducing the cellular oxidative stress (Banihani et al, 2013), an imbalance between oxidants, mainly ROS (Alzoubi et al, 2019), and antioxidants to the favor of the former (Banihani, 2018;Mahmoodi, Koohpeyma, Saki, Maleksabet, & Zare, 2019). Among the identified active antioxidant compounds in PGJ are cyanidin-3,5-O-diglucoside, pelargonidin-3,5-O-diglucoside, ellagitannins, punicalagin, and punicic acid (Di Stefano et al, 2019;Ding et al, 2017;Russo et al, 2018;Shabbir et al, 2017). PGJ including its active punicalagin compound was found to enhance the activity of enzymes involved in oxidants detoxification such as catalase, peroxidase, SOD, and GSH reductase (GR) (Rock et al, 2008;Rozenberg, Howell, & Aviram, 2006).…”

Section: Discussionmentioning

confidence: 99%

Effect of fresh pomegranate juice on the level of melatonin, insulin, and fasting serum glucose in healthy individuals and people with impaired fasting glucose

Banihani

Fashtaky

Makahleh

et al. 2019

Food Science & Nutrition

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Pomegranate juice (PGJ) is rich in unique bioactive compounds that can be used in the management of various diseases/disorders such as cancer, heart disease, Alzheimer disease, hypertension, and diabetes. Here, we aimed to investigate the effects of fresh PGJ on levels of melatonin, insulin, and fasting blood glucose in people with impaired fasting glucose (IFG). The study was a randomized clinical trial in which 28 participants (10 males, 18 females) with IFG were recruited from Irbid Central Laboratory and the Diabetes Technology. Blood specimens from each participant were collected before (−5 min), and 1 and 3 hr after PGJ administration at 1.5 ml/kg of the body weight, and melatonin, insulin, and glucose were measured. People with IFG, but not healthy individuals, had significant antihyperglycemic response (p < .0001) to PGJ 3 hr after ingesting the juice. This response was not correlated with the age of participants (p = .4287).In addition, homeostatic model assessment of insulin resistance was significantly decreased (p < .0001) among people with IFG 3 hr after ingesting the juice. Moreover, 1 hr after PGJ administration, decreases in melatonin and increases in insulin were significantly observed among healthy (p = .0284, p = .0017) and IFG (p = .0056, p = .0007) individuals, respectively. In conclusion, fresh PGJ lowers melatonin, increases the level of insulin, and ameliorates insulin resistance in people with IFG.

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“…Punicic acid (9-trans, 11-cis, 13-trans) is the main CLnA (~72%) found in PO (Cao et al, 2014). The PO is considered safe at 4.3 g/kg body weight/day (Shabbir et al, 2017), while PuA is also nontoxic in humans due to its application as bioactive component in foods over centuries (Anusree, Nisha, Priyanka, & Raghu, 2015). Among the different TAG compounds in PO, TPARs are the most prominent and pharmacologically active.…”

Section: Discussionmentioning

confidence: 99%

Preparation, optimization, and pharmacokinetic study of nanoliposomes loaded with triacylglycerol‐bound punicic acid for increased antihepatotoxic activity

Adu‐Frimpong

Firempong

Omari‐Siaw

et al. 2018

Drug Development Research

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Punicic acid of pomegranate oil (PAP) has gained heightened interest due to several health benefits, such as anticarcinogenic, antidiabetic, and antiatherosclerotic properties. However, these bioactivities have been hampered by chemical instability, poor water solubility, rapid metabolism, and low bioavailability of PAP. Therefore, this study was aimed at optimizing the liposomal formulation of Triacylglycerol‐bound punicic acid with its regioisomers (TPAR) for improved oral bioavailability and increased hepatoprotection through antioxidation and anti‐inflammation. Herein, the optimized TPAR nanoliposome (TPAR‐NL) was developed using thin‐film dispersion method and subsequently characterized with appropriate indices. The optimized TPAR‐NL produced fairly stable spherical nanoparticles (˂ 200 nm) with encapsulation efficiency (%EE) of 85.77%, as well as enhanced in vitro release and improved oral bioavailability. The TPAR‐NL exhibited profound antihepatotoxic effect in mice pretreated with carbon tetrachloride (CCl4) via reduction of serum alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels compared with free TPAR. The TPAR‐loaded liposome also significantly reduced oxidative stress by increasing superoxide dismutase and glutathione levels while lowering malonaldehyde concentration compared with the free TPAR. The TPAR‐LNF further exhibited remarkable anti‐inflammatory activity compared with the free drug via inhibition of interleukin‐6 and tumor necrosis factor‐alpha generation. Thus, the developed nanoliposomes potentiated the antihepatotoxic activity of TPAR via antioxidation and anti‐inflammation.

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Punicic acid: A striking health substance to combat metabolic syndromes in humans

Cited by 61 publications

References 67 publications

Preventing oxidation of canola and sunflower oils by addition of pomegranate seed oil

Preventing oxidation of canola and sunflower oils by addition of pomegranate seed oil

Effect of fresh pomegranate juice on the level of melatonin, insulin, and fasting serum glucose in healthy individuals and people with impaired fasting glucose

Preparation, optimization, and pharmacokinetic study of nanoliposomes loaded with triacylglycerol‐bound punicic acid for increased antihepatotoxic activity

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