Punicalagin Opposes Gentamicin Nephrotoxicity in Rats: Role of Nrf2 and NF-κB Pathways

Abstract

MATERIALS AND METHODS Laboratory animalsSprague-Dawley male rats (weight 200-220 g, each) were acquired from the animal house of King Khalid University, Abha, Saudi Arabia. They were accommodated at 24°C, 45% humidity, and 12 h light/dark cycle. They were supplied with ordinary chew and tap water ad. libitum, and were accustomed for 1 week. The study protocol was approved by the