Punicalagin isolated from Punica granatum husk can decrease the inflammatory response in RAW 264.7 macrophages

Berköz, Mehmet; Allahverdiyev, Oruç

doi:10.5505/ejm.2017.08760

Cited by 6 publications

(10 citation statements)

References 22 publications

(27 reference statements)

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“…These results are confirmed by a previous report that showed that P. guajava leaf extract significantly inhibited the production of NO and prostaglandin E2 (PGE2) [65]. According to Berkoz and Allahverdiyev's experiments, punicalagin, hydrolysable tannins, isolated from P. granatum can decrease the production of NO in a dose-dependent manner without affecting the viability of cells [66]. P. granatum and P. guajava leaf extracts exhibited high antioxidant activity and a high level of No inhibition, but the bark extracts of C. arborea, G. decora, S. obtusa, and F. hispida did not show such high levels of these activities.…”

Section: Effects Of the Extracts On The Production Of Nosupporting

confidence: 88%

“…decrease the production of NO in a dose-dependent manner without affecting the viability of cells [66]. P. granatum and P. guajava leaf extracts exhibited high antioxidant activity and a high level of No inhibition, but the bark extracts of C. arborea, G. decora, S. obtusa, and F. hispida did not show such high levels of these activities.…”

Section: Effects Of the Extracts On The Production Of Nomentioning

confidence: 89%

“…P. granatum leaf extracts can be used to reduce NO production and cytokine gene expression during LPS treatment [70]. Hydrolyzable tannins from P. granatum were also shown to have significantly decreased carrageenan-induced mice paw edema and to have inhibited iNOS and COX-2 expression [66,71].…”

Section: Effects Of the Extracts On Proinflammatory Cytokine Expression And Productionmentioning

confidence: 99%

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Anti-Inflammatory and Antioxidant Activities of Medicinal Plants Used by Traditional Healers for Antiulcer Treatment

et al. 2019

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For centuries, many kinds of native plants and their products have been used for the treatment of gastric ulcers by traditional healers in Phayao province. The current study aimed to investigate the polyphenol content in some of these medicinal plants and to point out the relationship between their antioxidant capacity and anti-inflammatory activities. Six species were selected based on ethnopharmacologic considerations: Punica granatum L., Psidium guajava L., Careya arborea Roxb., Gochnatia decora (Kurz) Cabr., Shorea obtusa Wall. ex Blume, and Ficus hispida L.f. The leaves or bark of these plants were extracted with 70% ethanol and water. Anti-inflammatory and antioxidant activities of the extracts were analyzed based on nitric oxide (NO) and proinflammatory cytokine production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and through the determination of scavenging activity. The results demonstrated that the ethanol extract from P. granatum and P. guajava leaves significantly inhibited NO production by suppressing nitric oxide synthase. The extracts also inhibited tumor necrosis factor-α, interleukin-1, and interleukin-6 in terms of both mRNA and protein levels and possessed high antioxidants. These extracts were shown to contain the highest amount of polyphenols. Our study concluded that among the plants studied, P. granatum and P. guajava have the most significant anti-inflammatory and antioxidant activities and polyphenols. These plants may have the potential for use in gastric ulcer therapy due to their indicated properties. Future research should focus on the isolation of their active compounds and their in vivo biological activities. Their beneficial applications need to be warranted by such evidence.

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Section: Effects Of the Extracts On The Production Of Nosupporting

confidence: 88%

Section: Effects Of the Extracts On The Production Of Nomentioning

confidence: 89%

Section: Effects Of the Extracts On Proinflammatory Cytokine Expression And Productionmentioning

confidence: 99%

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Anti-Inflammatory and Antioxidant Activities of Medicinal Plants Used by Traditional Healers for Antiulcer Treatment

et al. 2019

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“…The antioxidant potential of punicalagin has already been reported by many researchers such as Clementi et al (2018), Kim et al (2017), Pathakoti et al (2017) and Berköz and Allahverdiyev (2017) among others, which contributes to continuous and increasing interest in this compound. Taking into consideration the reported evidence, supplements containing punicalagin represent a promising intervention tool for the prevention and/or treatment of human cardiovascular diseases.…”

Section: Hydrolysable Tanninsmentioning

confidence: 85%

“…This compound can also end up in pomegranate juice during the fruit's processing. Studies report anti-cancer, anti-inflammatory, and antioxidant properties (Cerdá et al, 2003;Berköz and Allahverdiyev, 2017;Liu et al, 2019) for this compound.…”

Section: Hydrolysable Tanninsmentioning

confidence: 99%

Pomegranate as a natural source of phenolic antioxidants

Arruda¹,

Lima²,

Casarotti³

et al. 2020

JFB

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Pomegranate, a recognized source of phenolic compounds, has been associated with health-promoting benefits, mostly due to its antioxidant activity. Ellagic and gallic acids, anthocyanins, and ellagitannins are the main phenolics in pomegranate, showing antioxidant activity. For this reason, pomegranate has been used in foods, such as meat products, as an attempt to retard lipid oxidation and increase shelf-life. In recent years, in vitro, in vivo, and human studies reported the antioxidant activity of pomegranate, especially its peels, with reduced incidence of chronic diseases (e.g., cardiovascular ailments, cancer, neurodegenerative disease, type 2 diabetes, chronic kidney disease). This review aims to present the main antioxidant compounds on pomegranate and their biological effects, the antioxidant activity of pomegranate-based foods, the application of pomegranate as a natural antioxidant food additive, the role of pomegranate in the prevention and management of chronic diseases, as well as the trends and prospects regarding the application of pomegranate in innovative food and health.

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Effect of punicalagin on the autophagic cell death in triple-negative breast cancer cells

Bhutta,

Go,

Choi

2024

Toxicol Res.

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Punicalagin isolated from Punica granatum husk can decrease the inflammatory response in RAW 264.7 macrophages

Cited by 6 publications

References 22 publications

Anti-Inflammatory and Antioxidant Activities of Medicinal Plants Used by Traditional Healers for Antiulcer Treatment

Anti-Inflammatory and Antioxidant Activities of Medicinal Plants Used by Traditional Healers for Antiulcer Treatment

Pomegranate as a natural source of phenolic antioxidants

Effect of punicalagin on the autophagic cell death in triple-negative breast cancer cells

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