Punica granatum improves renal function in gentamicin-induced nephropathy in rats via attenuation of oxidative stress

Mestry, Snehal N.; Gawali, Nitin B.; Pai, Sarayu A.; Gursahani, Malvika; Dhodi, Jayesh B.; Munshi, Renuka

doi:10.1016/j.jaim.2017.09.006

Cited by 35 publications

(33 citation statements)

References 25 publications

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“…The levels of creatinine and urea in the serum of the groups that received GM and pre-treated with cinnamon and/or parsley oils were significantly declined, suggesting the protective potentials of cinnamon and parsley against kidney damage induced by GM. As mentioned before, after GM treatment, the use of compounds that possesses antioxidant effect improves renal function (Mestry et al, 2018). Serum creatinine and urea levels and the results of pathohistological analysis reflected the development of kidney impairment in GM-administered rats.…”

Section: Resultsmentioning

confidence: 63%

Nephroprotective Effects of Cinnamon and/or Parsley Oils against Gentamicin-Induced Nephrotoxicity in Rats

Elkomy¹,

Aboubakr²,

Medhat³

et al. 2020

J. Anim. Vet. Adv.

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In the present study, the nephroprotective potentials of cinnamon and/or parsley oils was assessed on gentamicin (GM)-induced nephrotoxicity in rats. About 49 male rats were assigned randomly into 7 equal groups (7 rats each). Group 1-3: were orally administered normal saline, cinnamon oil (400 mg kgG 1 b.wt.) and parsley oil (200 mg kgG 1 b.wt.), respectively, once daily for 30 consecutive days. Group 4: rats in this group were intraperitoneally injected with GM (100 mg kgG 1 b.wt.) in the last 10 days (20-30 th day) of the experiment. Group 5: rats in this group were given cinnamon and GM while rats in group 6 were administered parsley and GM. Group 7: rats in this group were administered cinnamon and parsley plus GM. At the end of the experiment, rats were sacrificed, serum samples and kidney specimens were collected for biochemical and oxidative status evaluation. Rats administered GM alone showed significant increases in serum concentrations of creatinine, urea and glucose while renal tissue levels of superoxide dismutase, catalase and glutathione reductase were significantly declined. Additionally, the malondialdehyde level was significantly elevated in kidney tissues. Also, GM administration caused renal histopathological alterations. The altered levels of various parameters provoked by GM toxicity were restored towards normal levels by cinnamon and/or parsley oils administration. These results suggested the nephroprotective potentials of cinnamon and/or parsley oils in rats, probably triggered by their antioxidant phytoconstituents.

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Section: Resultsmentioning

confidence: 63%

Nephroprotective Effects of Cinnamon and/or Parsley Oils against Gentamicin-Induced Nephrotoxicity in Rats

Elkomy¹,

Aboubakr²,

Medhat³

et al. 2020

J. Anim. Vet. Adv.

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“…Furthermore, a previous study showed that the isoprenoid 10-hydroxyloganin had an insecticidal effect [83]. The limonoid khayanthone was detected in Punica granatum methanolic extract, which exhibited antioxidant potentiality [84]. The compounds 13R-hydroxy-9E,11Z-octadecadienoic, acid bis (2-hydroxypropyl) amine, 9-aminononanoic acid, and 10-aminodecanoic acid found in this plant, which belong to fatty acids, amino alcohols, and amino acid derivatives, were proved in the literature to have antiradical activity [85,86].…”

Section: Antioxidant Activitiesmentioning

confidence: 95%

HR-LCMS-Based Metabolite Profiling, Antioxidant, and Anticancer Properties of Teucrium polium L. Methanolic Extract: Computational and In Vitro Study

et al. 2020

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In this study, we investigate the phytochemical profile, anticancer, and antioxidant activities of Teucrium polium methanolic extract using both in vitro and in silico approaches. The results showed the identification of 29 phytochemical compounds belonging to 13 classes of compounds and 20 tripeptides using High Resolution-Liquid Chromatography Mass Spectrometry (HR-LCMS). 13R-hydroxy-9E,11Z octadecadienoic acid, dihydrosamidin, valtratum, and cepharantine were the main compounds identified. The tested extract showed promising antioxidant activities (ABTS-IC50 = 0.042 mg/mL; 1,1-diphenyl-2-picrylhydrazyl (DPPH)-IC50 = 0.087 mg/mL, β-carotene-IC50 = 0.101 mg/mL and FRAP-IC50 = 0.292 mg/mL). Using both malignant Walker 256/B and MatLyLu cell lines, T. polium methanolic extract showed a dose/time-dependent antitumor activity. The molecular docking approach revealed that most of the identified molecules were specifically binding with human peroxiredoxin 5, human androgen, and human progesterone receptors with high binding affinity scores. The obtained results confirmed that T. polium is a rich source of bioactive molecules with antioxidant and antitumor potential.

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“…The protective effect of PGPE on the creatinine and urea could be attributed to its antioxidant effect as ROS has been found to be involved in the impairment of glomerular filtration rate [ 57].…”

Section: Discussionmentioning

confidence: 99%

Effects of Punica granatum peel extract and/ or Sitagliptin on induced diabetic nephropathy in adult male albino rats

Mohamed

Al-Eryan

El-sayed

et al. 2020

Journal of Recent Advances in Medicine

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Background: Type 2 diabetes mellitus (T2DM) represents about 90% of diabetic cases. Diabetic nephropathy (DN) is one of the most serious complications of diabetes. Sitagliptin has an important role in enhancement of the Glucagon-like peptide receptor (GLP-1R) which present in the kidneys, so it may have a role in enhancement of the kidney function in T2DM. Also, Punica granatum peels extract (PGPE) is a herb which has anti-hyperglycemic and antioxidant activities. Objective: This study was designed to investigate the role of PGPE and/or sitagliptin on renal functions in induced diabetes. Methodology: The current study was performed on 60 adult male albino rats. Rats weighing 200 to 250 grams. Rats were divided into: Group I "normal control animals" consists of 20 rats (divided into group 1: normal control and group 2: vehicle received control) 10 rats / each. Group II "Diabetic animals" consist of 40 rats were divided into 4 treated groups: (Diabetic, PGPE, Sitagliptin, sitagliptin and PGPE) 10 rats /each. At the end of experimental period (6 weeks), urinary protein, fasting blood glucose (FBG), urea, blood urea nitrogen (BUN), creatinine, malonyldialdehyde (MDA), tumor necrosis factor alpha (TNFα), antioxidant enzymes and histopathology of renal tissue were assayed. Results: In diabetic rats there were increased FBG, urea, BUN, creatinine, urinary protein, MDA and TNFα with decreased GSH and SOD. Treatment with PGPE and sitagliptin caused decrease in SFBG, urea, BUN, creatinine, TNFα, MDA and total protein with increase in GSH and SOD. Histopathological examination of diabetic rats revealed dilated glomerular space and dilated degenerated tubules. Treatment with PGPE and sitagliptin revealed improvement in the glomerular space with less tubular dilatation. Conclusion: Results of the present work showed that combination of PGPE and sitagliptin have synergistic effects for each other and have a better renoprotective effects in diabetic rats.

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Punica granatum improves renal function in gentamicin-induced nephropathy in rats via attenuation of oxidative stress

Abstract: Data suggests that MPGL attenuated oxidative stress associated renal injury by preserving antioxidant enzymes, reducing lipid peroxidation and inhibiting inflammatory mediators such as TNF-α.

Cited by 35 publications

References 25 publications

Nephroprotective Effects of Cinnamon and/or Parsley Oils against Gentamicin-Induced Nephrotoxicity in Rats

Nephroprotective Effects of Cinnamon and/or Parsley Oils against Gentamicin-Induced Nephrotoxicity in Rats

HR-LCMS-Based Metabolite Profiling, Antioxidant, and Anticancer Properties of Teucrium polium L. Methanolic Extract: Computational and In Vitro Study

Effects of Punica granatum peel extract and/ or Sitagliptin on induced diabetic nephropathy in adult male albino rats

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