Punctate keratoses of the palms and soles and keratotic pits of the palmar creases

Rustad, O.J.; Vance, J. Corwin

doi:10.1016/0190-9622(90)70066-q

Cited by 32 publications

(39 citation statements)

References 35 publications

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“…Histologically the characteristic feature is the cup-shaped hyperkeratotic plug depressing the epidermis. Hyperkeratosis is usually orthokeratotic 4,5,8,10 , but other authors have observed parakeratosis and a mild dermal mononuclear infiltration 11 as shown in our patient. Pyknotic cells have been reported to cause vacuolization as in our case 12 .…”

Section: Discussionmentioning

confidence: 72%

“…Although some cases have been reported with a history of arsenic exposure and latent syphilis 6 , or with a family history 4,5 , our patient had neither family history, and history of syphilis nor arsenic exposure. Our patient was a manual worker and recognized hard labor exacerbated the lesions.…”

Section: Discussionmentioning

confidence: 90%

“…Pyknotic cells have been reported to cause vacuolization as in our case 12 . The relationship between the keratotic plug and the acrosyringium have been found in some cases 4,5,10 . We believe this relationship could be merely casual, due to the palmar location of the lesions, and if we could have taken some more sections of other pits, we would have found it.…”

Section: Discussionmentioning

confidence: 99%

“…The condition affects young and middle-aged adults without any sex predominance. In Black, KPPC is a rather common finding, but it is a very rare disease in other races 3,4 . Although there are some reports with a autosomal dominant inheritance pattern 4,5 , KPPC is usually sporadic.…”

Section: Discussionmentioning

confidence: 99%

“…In Black, KPPC is a rather common finding, but it is a very rare disease in other races 3,4 . Although there are some reports with a autosomal dominant inheritance pattern 4,5 , KPPC is usually sporadic. In most cases, the condition is asymptomatic, but some patients experience tenderness or pain.…”

Section: Discussionmentioning

confidence: 99%

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A Case of Keratosis Punctata of the Palmar Creases

Mo¹,

Kim²,

Lee³

et al. 2002

Ann Dermatol

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A 22-year-old Bangladeshian man presented with slightly painful, multiple, craterlike depressions confined to the palmar creases of the digits and palms. The first lesions, which were punctiform hyperkeratotic plugs, were noticed 4 years before. Occasionally, some lesions became painful, thicker and then were removed spontaneously, leaving tiny pits, where a new plug developed again a few days later. He was a manual worker with neither history of arsenic exposure nor syphilis. No lesion was detected on the soles. There was no familial history of similar palmar lesions.On cutaneous examination, numerous, tiny, hyperkeratotic, skin colored pits were found on the palmar creases of both hands, with a predilection for the transpalmar crease and the proximal interphalangeal joint crease of the left hand (Fig. 1). He was generally in good condition and had no other skin lesion.Histologic examination of the serial section of a hyperkeratotic pit revealed cup-shaped epidermal central depression with marked parakeratotic hyperkeratosis and acanthosis. Mild perivascular lymphohistiocytic cell infiltration was seen in the upper dermis. Focal vacuolated cells were shown in the epidermis, but vertical tiers of parakeratotic cells, clumped keratohyaline grunules and hypergranulosis were not shown (Fig. 2).He was treated with only topical emollients, resulting in moderate improvement. DISCUSSIONKeratosis punctata of the palmar creases (KPPC) was first described by Arnold 2 in 1947, in a white male, as a variant of Kyrle's disease. The condition is defined as the presence of punctiform hyperkeratotic plugs, with a raised horn, 1-4mm in diameter Keratosis punctata of the palmar creases (KPPC) is a rare skin condition characterized by punctiform hyperkeratotic pits confined to the palmar and digital creases. Although this condition has been regarded as a variant of classical punctate keratoses, there are some differences between classical punctate keratosis and KPPC. We herein report a case of KPPC in a 22-year-old man who had numerous, tiny, hyperkeratotic pits limited to the palmar creases of both hands with typical histologic findings.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Case of Keratosis Punctata of the Palmar Creases

Mo¹,

Kim²,

Lee³

et al. 2002

Ann Dermatol

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Inherited Disorders of Cornification

Oji

Metze

Traupe

2016

Rook's Textbook of Dermatology, Ninth Edition

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The majority of keratinization disorders are referred to as Mendelian disorders of cornification. This is a very broad group, clinically characterized by hyperkeratosis or visible scaling or both. This chapter deals with the ichthyoses, palmoplantar keratodermas (PPKs) and miscellaneous cornification disorders such as porokeratoses. It is aimed primarily at dermatologists and physician scientists who have to make a clinical diagnosis and provide adequate management for their patients. Therefore a nosology and classification scheme has been chosen that is based on clinicogenetic and morphological features. Clinical diagnoses are then discussed with their molecular pathology. Part of the chapter addresses the management of congenital ichthyoses. Various tables provide an overview on clinical and/or pathophysiologically related groups of diseases. Finally, several cornification disorders are discussed that do not have a genetic basis, but are acquired or are of unknown aetiology (e.g. acquired ichthyoses/PPKs or perforating keratotic disorders).

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