Punctate inner choroidopathy with atypical presentation

Albano, Juliana; Pires, Maria Campos; Paccola, Marcelo

doi:10.5935/0004-2749.20210018

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“…The diagnosis of PIC was established based on clinical features of the typical disease, which consist of multifocal, small (1/4–1/2 disc diameter, <250 μm), discrete, yellow-white punctate choroidal inflammatory lesions confined to the posterior pole without overlying vitritis or anterior chamber inflammation ( 2 , 8 ). Patients with atypical PIC lesions were excluded ( 8 , 14 ). Subjects were included once infective etiologies and other causes of choroiditis, such as tuberculosis were ruled out.…”

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confidence: 99%

Optical Coherence Tomography Findings of Underlying Choroidal Neovascularization in Punctate Inner Choroidopathy

et al. 2021

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Purpose: To analyze findings on optical coherence tomography (OCT) suggestive of choroidal neovascularization (CNV) in lesions of punctate inner choroidopathy (PIC).Methods: In this multi-center retrospective study, clinical data of patients with PIC were retrospectively analyzed. Quantitative data (height, width, and volume of PIC lesions), and qualitative data (disruption of ellipsoid zone (EZ)/Bruch's membrane (BM), outer retinal fuzziness, and choroidal back-shadowing) were compared between CNV+ and CNV– groups using Mann–Whitney U-test and Fischer's exact test.Results: In total, 35 eyes (29 patients; 21 women; mean age: 33.3 ± 6.5 years) were selected for analysis. Of the 35 PIC lesions studied, 17 had underlying CNV. Lesions with CNV+ had larger height, width, and volume (p < 0.001) and several distinctive features, such as disruption of EZ and BM, outer retinal fuzziness, and hypo-reflective back-shadowing (p < 0.001) compared with CNV—lesions.Conclusions: Quantitative and qualitative OCT analysis can aid in the prediction of an underlying CNV in the eyes with PIC.

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