Punctal and canalicular plugs: Indications, efficacy and safety

Best, Anne-Laurence; Labétoulle, Marc; Legrand, M.; Mgarrech, M.; Barreau, Emmanuel; Rousseau, Antoine

doi:10.1016/j.jfo.2018.12.003

Cited by 12 publications

(6 citation statements)

References 50 publications

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“…This advantage can help overcome the problems and complications that come with commercially available versions that only have limited sizes. [ 4 ] Another major advantage of these punctal plugs is their cost-effectiveness along with a very short printing time for something that can be individualized from person to person. With the hollow cylindrical part of the design used in this research, it can also prove to be an effective ocular drug delivery system where prolonged drug delivery can be achieved.…”

Section: Discussionmentioning

confidence: 99%

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Designing and making an open source, 3D-printed, punctal plug with drug delivery system

Khanna

Bawa

Sargunam

2022

Indian Journal of Ophthalmology

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With the advancement in the study of keratoconjunctivitis sicca and the scope of its treatment, punctal plugs are being widely used for the therapeutic management of dry eye disease. With the emergence of 3D printing in medicine, 3D printing of punctal plugs that have an inbuilt drug delivery system and also that can be personalized from patient to patient according to their punctum size can be a great therapeutic option. Another benefit of the device is that its printing takes a short period of time and is cost-effective. This study aimed at making an open source design and 3D printing an efficient model of a punctal plug with an inbuilt drug delivery system that can be eventually used for the treatment of various ocular diseases that require frequent drug instillation or blockage of the nasolacrimal pathway. The 3D design for the punctal plug was made using the open source application, FreeCAD, and slicing was done using the application ChituBox. After that, the plugs were printed using the LCD printer Crealty LD-002R. The material used was resin that was compatible with the Crealty LD-002R. Punctal plugs with satisfactory results were printed using the LCD printer. The punctal plugs showed suitable structure and were also easily reproduced in the 3D printer without any complications or setbacks.

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Section: Discussionmentioning

confidence: 99%

“…[ 3 ] To overcome this problem of frequent instillation in traditionally used artificial tears therapy, a coming of age concept of punctal plugs proves to be effective. [ 4 ]…”

mentioning

confidence: 99%

Designing and making an open source, 3D-printed, punctal plug with drug delivery system

Khanna

Bawa

Sargunam

2022

Indian Journal of Ophthalmology

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“…Moreover, it is known that silicone punctal plugs can traumatise the ocular surface in the setting of partial extrusion of the plug, especially in the context of rigid plugs with thick collarettes. 3 This case highlights the ocular surface trauma that may result when the plug's collarette is oriented towards the ocular surface. It further highlights the importance of evaluating the punctal position prior to and after plug placement, to ensure that no direct apposition of the plug to the ocular surface occurs.…”

Section: Descriptionmentioning

confidence: 93%

Punctal eversion with silicone plug resulting in ocular surface trauma

2020

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“…This biodegradability can help to avoid many complications caused by the permanent complete blockage of the lacrimal drainage system, such as canaliculitis and epiphora. [7,62] Compared with existing commercialized plugs, SFMA/FTN hydrogel plugs are liquid prior to use; they can be molded according to the shape of the lacrimal canaliculus, despite differences between individuals, and they can completely obstruct the canaliculus. Due to the admirable biodegradability of the SFMA/FTN hydrogel, lacrimal obstruction gradually cleared, and lacrimal drainage capacity gradually recovered.…”

Section: Treatment Of Dry Eye By Intracanalicular Injection Of Sfma/f...mentioning

confidence: 99%

“…Although, it has been reported there are significant improvements in symptomatic and clinical outcomes after treatment with plugs, many complications are associated with their use. [4,5] Some of the recognized complications of plugs include epiphora (overflow of tears), plug movement (or loss), infectious canaliculitis, [6][7][8] granuloma, and biofilm formation. [9,10] Thus, developing satisfactory lacrimal plugs for dry eye is of great importance.…”

Section: Introductionmentioning

confidence: 99%

In Situ Forming Hydrogel as a Tracer and Degradable Lacrimal Plug for Dry Eye Treatment

Xiao

Zheng

et al. 2022

Adv Healthcare Materials

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Lacrimal plug is an effective and widely therapeutic strategy to treat dry eye. However, almost all commercialized plugs are fixed in a certain design and associated with many complications, such as spontaneous plug extrusion, epiphora, and granuloma and cannot be traced in the long‐term. Herein, a simple in situ forming hydrogel is developed as a tracer and degradable lacrimal plug to achieve the best match with the irregular lacrimal passages. In this strategy, methacrylate‐modified silk fibroin (SFMA) is served as a network, and a self‐assembled indocyanine green fluorescence tracer nanoparticle (FTN) is embedded as an indicator to develop the hydrogel plug using visible photo‐crosslinking. This SFMA/FTN hydrogel plug has excellent biocompatibility and biodegradability, which can be noninvasively monitored by near‐infrared light. In vivo tests based on dry eye rabbits show that the SFMA/FTN hydrogel plug can completely block the lacrimal passages and greatly improve the various clinical indicators of dry eye. These results demonstrate that the SFMA/FTN hydrogel is suitable as an injectable and degradable lacrimal plug with a long‐term tracking function. The work offers a new approach to the development of absorbable plugs for the treatment of dry eye.

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Punctal and canalicular plugs: Indications, efficacy and safety

Cited by 12 publications

References 50 publications

Designing and making an open source, 3D-printed, punctal plug with drug delivery system

Designing and making an open source, 3D-printed, punctal plug with drug delivery system

Punctal eversion with silicone plug resulting in ocular surface trauma

In Situ Forming Hydrogel as a Tracer and Degradable Lacrimal Plug for Dry Eye Treatment

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