Pumping the Periosteum: A Feasibility Study

Saulačić, Nikola; Vunjak‐Novakovic, Gordana; Haga‐Tsujimura, Maiko; Nakahara, Ken; Gerbaix, Maude; Ferrari, Serge

doi:10.1097/sap.0000000000003108

Cited by 3 publications

(3 citation statements)

References 51 publications

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“…Anesthesia and surgical procedures were performed as previously described 27 . Anesthesia was induced with 8% isoflurane (Attane™, MINRAD Inc., Orchard Park, NY, USA) and 600 ml/min oxygen in the induction chamber.…”

Section: Methodsmentioning

confidence: 99%

“…The distraction screw was activated manually by using a hex key. Turning the distraction screw for a quarter of a complete turn (90°) resulted in a 0.1 mm elevation of the plate 27 . For relaxation, the distraction screw was turned back to the same amount as that used for activation.…”

Section: Methodsmentioning

confidence: 99%

“…Our preliminary data indicated that the distraction protocol alternated with relaxation (periosteal pumping [PP]) enhanced the apposition of new bone on the calvaria of rats 27 . Furthermore, introducing relaxation after two activations was beneficial for regenerating extended bone defects compared to the standardized PDO protocol 28 .…”

Section: Introductionmentioning

confidence: 99%

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Alternated activation with relaxation of periosteum stimulates bone modeling and remodeling

Saulacic,

Katagiri,

Fujioka-Kobayashi

et al. 2024

Sci Rep

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Gradual elevation of the periosteum from the original bone surface, based on the principle of distraction osteogenesis, induces endogenous hard and soft tissue formation. This study aimed to assess the impact of alternating protocols of activation with relaxation (periosteal pumping) on bone modeling and remodeling. One hundred and sixty-two adult male Wistar rats were used in this study. Four test groups with different pumping protocols were created based on the relaxation applied. Two control groups underwent an activation period without relaxation or only a single activation. One group was sham-operated. Periosteal pumping without period of activation induced gene expression in bone and bone remodeling, and following activation period enhanced bone modeling. Four test groups and control group with activation period equaled the values of bone modeling at the end-consolidation period, showing significant downregulation of Sost in the bone and periosteum compared to that in the sham group (p < 0.001 and p < 0.001, respectively). When all test groups were pooled together, plate elevation from the bony surface increased bone remodeling on day 45 of the observation period (p = 0.003). Furthermore, bone modeling was significantly affected by plate elevation on days 17 and 45 (p = 0.047 and p = 0.005, respectively) and by pumping protocol on day 31 (p = 0.042). Periosteal pumping was beneficial for increasing bone repair when the periosteum remained in contact with the underlaying bony surface during the manipulation period. Following periosteal elevation, periosteal pumping accelerated bone formation from the bony surface by the modeling process.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Alternated activation with relaxation of periosteum stimulates bone modeling and remodeling

Saulacic,

Katagiri,

Fujioka-Kobayashi

et al. 2024

Sci Rep

Self Cite

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Mechanoresponsive regulation of tissue regeneration during distraction osteogenesis

Hu,

Guo,

Tang

et al. 2024

The FASEB Journal

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Distraction osteogenesis is widely used for bone tissue engineering. Mechanical stimulation plays a central role in the massive tissue regeneration observed during distraction osteogenesis. Although distraction osteogenesis has been a boon for patients with bone defects, we still have limited knowledge about the intrinsic mechanotransduction that converts physical forces into biochemical signals capable of inducing cell behavior changes and new tissue formation. In this review, we summarize the findings for mechanoresponsive factors, including cells, genes, and signaling pathways, during the distraction osteogenesis different phases. These elements function for coupling of osteogenesis and angiogenesis via the Integrin‐FAK, TGF‐β/BMP, Wnt/β‐catenin, Hippo, MAPK, PI3K/Akt, and HIF‐1α signaling pathways in a mechanoresponsive niche. The available evidence further suggests the existence of a balance between the epithelial–mesenchymal transition and mesenchymal–epithelial transition under hypoxic stress. We also briefly summarize the current in silico simulation algorithms and propose several future research directions that may advance understanding of distraction osteogenesis in the era of bioinformation, particularly the integration of artificial intelligence models with reliable single‐cell RNA sequencing datasets. The objective of this review is to utilize established knowledge to further optimize existing distraction protocols and to identify potential therapeutic targets.

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Vertical Alveolar Ridge Regeneration by Means of Periosteal Activation—A Proof‐of‐Principle Study

Saulacic,

Lang,

Corluka

et al. 2024

J Clinic Periodontology

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AimTo assess the possibility of vertical alveolar ridge augmentation by means of activation of the periosteum.Materials and MethodsSix adult male Beagle dogs were used for the study. All premolars and first molars were extracted, and one vertical saucer‐shaped bony defect was created on each side of the mandible. After 3 months of healing, full‐thickness muco‐periosteal flaps were elevated, and one distraction device was placed on each side of the mandible. The distraction plate was left submerged, and the activation mechanism connected to the distraction rod was exposed intra‐orally. The protocol of periosteal activation (PP: periosteal ‘pumping’) was initiated after a latency of 7 days. The alternation of activation and relaxation at the rate of 0.35 mm/12 h during 5 days was followed by the sole activation of 0.35 mm/12 h for 5 days (PP group). Devices were left inactivated on the contralateral control side of the mandible (C group). All animals were euthanized after 8 weeks of consolidation. Samples were analysed histologically and by means of micro‐CT.ResultsNew mature lamellar bone was formed over the pristine bone in all groups. More intensive signs of bone modelling and remodelling were observed in the PP group compared to the C group. Mean new bone, bone marrow, connective tissue and total volumetric densities were greater in the PP group (p < 0.001, p = 0.001, p = 0.003 and p < 0.001, respectively). No differences were observed in the relative area parameters. Total tissue volume and bone volume were higher in the PP group (p = 0.031 and p = 0.076, respectively), while the bone mineral densities were higher in the C group (p = 0.041 and p = 0.003, respectively). Trabecular number, trabecular thickness and trabecular separation values were similar between the two groups.ConclusionsRegeneration of vertical alveolar bone ridge defects may be enhanced by activation of the periosteum, without the application of bone grafting materials.

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Pumping the Periosteum: A Feasibility Study

Cited by 3 publications

References 51 publications

Alternated activation with relaxation of periosteum stimulates bone modeling and remodeling

Alternated activation with relaxation of periosteum stimulates bone modeling and remodeling

Mechanoresponsive regulation of tissue regeneration during distraction osteogenesis

Vertical Alveolar Ridge Regeneration by Means of Periosteal Activation—A Proof‐of‐Principle Study

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