Pump and exchanger mechanisms in a model of smooth muscle

Skinner, Frances K.; Ward, C. A.; Bardakjian, Berj L.

doi:10.1016/0301-4622(93)80007-6

Cited by 10 publications

(7 citation statements)

References 38 publications

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“…Few models of gastrointestinal SM cells exist (31,38), and only the more recent ones (6) are consistent with the current theory that SM cells are not able to produce slow waves themselves but need to be activated by the ICC network. Few models of gastrointestinal SM cells exist (31,38), and only the more recent ones (6) are consistent with the current theory that SM cells are not able to produce slow waves themselves but need to be activated by the ICC network.…”

supporting

confidence: 63%

“…Interstitial cells of Cajal (ICC) are responsible for the spontaneous and omnipresent electrical activity in the stomach. Few models of gastrointestinal SM cells exist (31,38), and only the more recent ones (6) are consistent with the current theory that SM cells are not able to produce slow waves themselves but need to be activated by the ICC network. In line with recent experimental evidence, the model describes how the interplay between the mitochondria and the endoplasmic reticulum in cycling intracellular Ca 2ϩ provides the primary regulatory signal for the initiation of the slow wave.…”

mentioning

confidence: 53%

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Quantitative cellular description of gastric slow wave activity

Corrias¹,

Buist²

2008

American Journal of Physiology-Gastrointestinal and Liver Physi

119

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Interstitial cells of Cajal (ICC) are responsible for the spontaneous and omnipresent electrical activity in the stomach. A quantitative description of the intracellular processes whose coordinated activity is believed to generate electrical slow waves has been developed and is presented here. In line with recent experimental evidence, the model describes how the interplay between the mitochondria and the endoplasmic reticulum in cycling intracellular Ca(2+) provides the primary regulatory signal for the initiation of the slow wave. The major ion channels that have been identified as influencing slow wave activity have been modeled according to data obtained from isolated ICC. The model has been validated by comparing the simulated profile of the slow waves with experimental recordings and shows good correspondence in terms of frequency, amplitude, and shape in both control and pharmacologically altered conditions.

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supporting

confidence: 63%

mentioning

confidence: 53%

Quantitative cellular description of gastric slow wave activity

Corrias¹,

Buist²

2008

American Journal of Physiology-Gastrointestinal and Liver Physi

119

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show abstract

“…Moreover, our knowledge of the different nature and functionality of SM cells and ICC is relatively recent and consequently a number of previously published works do not incorporate this distinction (e.g., Mifthakov et al 33 ). Similarly, Skinner et al 46 developed a generic model of SM electrophysiology that is now inconsistent with current experimental data. An attempt to describe the underlying electrophysiology of a generic SM was made by Lang and Rattray-Wood.…”

Section: Introductionmentioning

confidence: 94%

A Quantitative Model of Gastric Smooth Muscle Cellular Activation

2007

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A physiologically realistic quantitative description of the electrical behavior of a gastric smooth muscle (SM) cell is presented. The model describes the response of a SM cell when activated by an electrical stimulus coming from the network of interstitial cells of Cajal (ICC) and is mediated by the activation of different ion channels species in the plasma membrane. The conductances (predominantly Ca2+ and K+) that are believed to substantially contribute to the membrane potential fluctuations during slow wave activity have been included in the model. A phenomenological description of intracellular Ca2+ dynamics has also been included because of its primary importance in regulating a number of cellular processes. In terms of shape, duration, and amplitude, the resulting simulated smooth muscle depolarizations (SMDs) are in good agreement with experimentally recordings from mammalian gastric SM in control and altered conditions. This model has also been designed to be suitable for incorporation into large scale multicellular simulations.

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“…At present the available biophysically based models describe only non-human cells, and mainly focus on the stomach [9], [10]. Earlier SMC models by Miftakhov et al [11], [12] and Skinner et al [13] describe the SMC as being self-excitatory and thus are not consistent with more recent findings where ICC provide the pacemaking activity. In the small intestine, two biophysically based and one phenomenological model of ICC exist, but there exists only a phenomenological model of intestinal SMC activity [14]–[16].…”

Section: Introductionmentioning

confidence: 96%

A Quantitative Model of Human Jejunal Smooth Muscle Cell Electrophysiology

et al. 2012

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Recently, a number of ion channel mutations have been identified in the smooth muscle cells of the human jejunum. Although these are potentially significant in understanding diseases that are currently of unknown etiology, no suitable computational cell model exists to evaluate the effects of such mutations. Here, therefore, a biophysically based single cell model of human jejunal smooth muscle electrophysiology is presented. The resulting cellular description is able to reproduce experimentally recorded slow wave activity and produces realistic responses to a number of perturbations, providing a solid platform on which the causes of intestinal myopathies can be investigated.

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Pump and exchanger mechanisms in a model of smooth muscle

Cited by 10 publications

References 38 publications

Quantitative cellular description of gastric slow wave activity

Quantitative cellular description of gastric slow wave activity

A Quantitative Model of Gastric Smooth Muscle Cellular Activation

A Quantitative Model of Human Jejunal Smooth Muscle Cell Electrophysiology

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