“…Many mammalian PUM targets have been identified using high-throughput approaches (Chen et al, 2012; Galgano et al, 2008; Hafner et al, 2010; Morris et al, 2008), revealing diverse functions for these proteins in germline homeostasis (Chen et al, 2012; Spassov and Jurecic, 2003), cell cycle control (Kedde et al, 2010; Miles et al, 2012) and neuronal activity and function (Driscoll et al, 2013; Vessey et al, 2010). Notably, Pum1 haploinsufficiency in mice has recently been reported to result in neurodegeneration (Gennarino et al, 2015), demonstrating that PUM dosage must be precisely controlled in vivo to avoid significant pathologic consequences. Nevertheless, the mechanisms through which PUM activity is regulated remain unknown.…”