Pumilio Puf domain RNA-binding proteins in Arabidopsis

Abbasi, Nazia; Park, Youn‐Il; Choi, Sang‐Bong

doi:10.4161/psb.6.3.14380

Cited by 40 publications

(28 citation statements)

References 56 publications

(69 reference statements)

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“…This class of proteins is involved with repressing translation [ 53 ]. Its Arabidopsis thaliana homologues APUM1 , APUM2 , APUM5 and APUM6 are all highly transcribed in the shoot meristem and newly emerging leaves [ 54 ]. Francischini and Quaggio [ 55 ] demonstrated that APUM-1 to APUM-6 are able to bind specifically to APUM-binding elements in the 3′ UTR of WUSCHEL , CLAVATA-1 , PINHEAD/ZWILLE and FASCIATA-2 transcripts, reported to code for proteins involved in diverse developmental processes, including shoot meristem organization, stem cell maintenance and maintenance of cellular organization of apical meristems [ 56 – 60 ]; WUSCHEL was also identify near the QTL controlling lc in tomato [ 61 ], and thus we might hypothesized an involvement of Pumilio gene in fruit development.…”

Section: Discussionmentioning

confidence: 99%

Association Mapping for Fruit, Plant and Leaf Morphology Traits in Eggplant

et al. 2015

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An eggplant (Solanum melongena) association panel of 191 accessions, comprising a mixture of breeding lines, old varieties and landrace selections was SNP genotyped and phenotyped for key breeding fruit and plant traits at two locations over two seasons. A genome-wide association (GWA) analysis was performed using the mixed linear model, which takes into account both a kinship matrix and the sub-population membership of the accessions. Overall, 194 phenotype/genotype associations were uncovered, relating to 30 of the 33 measured traits. These associations involved 79 SNP loci mapping to 39 distinct chromosomal regions distributed over all 12 eggplant chromosomes. A comparison of the map positions of these SNPs with those of loci derived from conventional linkage mapping showed that GWA analysis both validated many of the known controlling loci and detected a large number of new marker/trait associations. Exploiting established syntenic relationships between eggplant chromosomes and those of tomato and pepper recognized orthologous regions in ten eggplant chromosomes harbouring genes influencing breeders’ traits.

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Section: Discussionmentioning

confidence: 99%

Association Mapping for Fruit, Plant and Leaf Morphology Traits in Eggplant

et al. 2015

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“…Pumilio proteins bind to specific sequences in the 3′ UTR of target mRNAs and function as translational repressors during development and differentiation (Wickens et al, 2002;de Moor et al, 2005). In Arabidopsis, several Pumilio RNAbinding protein genes (APUM1, APUM2, APUM5 and APUM6) showed higher expression in shoot meristems, suggesting that these genes are required for active cell division (Abbasi et al, 2011). Indeed, the apum23 mutant had shorter roots and a slower growth phenotype (Abbasi et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

A wheat homologue of <i>PHYTOCLOCK 1</i> is a candidate gene conferring the early heading phenotype to einkorn wheat

et al. 2012

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An X-ray mutant showing an early flowering phenotype has been identified in einkorn wheat (Triticum monococcum L.), for which a major QTL for heading time was previously mapped in the telomeric region on the long arm of chromosome 3A. Recent advances in Triticeae genomics revealed that the gene order in this region is highly conserved between wheat and barley. Thus, we adopted a hypothetical gene order in barley, the so-called GenomeZipper, to develop DNA markers for fine mapping the target gene in wheat. We identified three genes tightly linked to the early heading phenotype. PCR analysis revealed that early-flowering is associated with the deletion of two genes in the mutant. Of the two deleted genes, one is an ortholog of the LUX ARRHYTHMO (LUX)/PHYTOCLOCK 1 (PCL1) gene found in Arabidopsis, which regulates the circadian clock and flowering time. We found distorted expression patterns of two clock genes (TOC1 and LHY) in the einkorn pcl1 deletion mutant as was reported for the Arabidopsis lux mutant. Transcript accumulation levels of photoperiod-response related genes, a photoperiod sensitivity gene (Ppd-1) and two wheat CONSTANS-like genes (WCO1 and TaHd1), were significantly higher in the einkorn wheat mutant. In addition, transcripts of the wheat florigen gene (WFT) accumulated temporally under shortday conditions in the einkorn wheat mutant. These results suggest that deletion of WPCL1 leads to abnormally higher expression of Ppd-1, resulting in the accumulation of WFT transcripts that triggers flowering even under short-day conditions. Our observations from gene mapping, gene deletions, and expression levels of flowering related genes strongly suggest that WPCL1 is the most likely candidate gene for controlling the early flowering phenotype in the einkorn wheat mutant.

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“…Recent advance in identifying the enormous amount of cellular RNA, coding or noncoding, also suggests that cells might encode more RBPs with unique RNA-binding activity and protein-protein interaction than previously known. The Pumillio/FBF (PUF) repeat domain of pumillio protein was first identified in the Drosophila that binds the 3'UTR of the hunchback mRNA (Edwards et al 2001); however, it is now identified as a specific RBP from yeast in plant and vertebrate animals (Spassov & Jurecic, 2003;Abbasi et al 2011). Since the core of the β-catenin Arm repeats structurally resemble the PUF repeats, forming triple helices in each repeat and forming superhelical rods, it probably acts as a RBP similar to Pumillo.…”

Section: Apc and β-Catenin Mutations And Target Genes In Cancermentioning

confidence: 99%

Multitasking β-catenin: from adhesion and transcription to RNA regulation

Hur

Jeong

2013

Animal Cells and Systems

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β-Catenin is an evolutionally conserved protein which orchestrates myriad biological processes by regulating Wnt signaling and cell adhesion. The importance of the dual roles of β-catenin protein (signaling and structural) is highlighted throughout the development and adult life of all metazoan animals. β-Catenin is located in the cadherin-based adherent junctions in the plasma membrane of epithelial cells; upon Wnt activation, it accumulates and translocates to the nucleus in order to activate transcription. Thus, mutations in β-catenin and the components of the Wnt signal transduction pathway underline the aberrant activation of Wnt/β-catenin signaling in human diseases and cancers. In this review, we briefly summarize the core functions of β-catenin relevant to Wnt signaling and adhesion and introduce the additional and novel role of β-catenin related to the regulation of RiboNucleoAcid (RNA) metabolism. Such multiple functions of β-catenin can be understood by examining its structure and complex with the plethora of interacting proteins. Also, molecular evolution analysis has been used to understand the origin of multifunctionality of β-catenin. We will also discuss the newly identified role of β-catenin as an RNA-binding protein and as a regulator of RNA stability and splicing. It is hoped that future research will shed light on any unexpected findings by clarifying the RNA-mediated mechanism of β-catenin and the implication to Wnt-regulated pathogenesis.

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Pumilio Puf domain RNA-binding proteins in Arabidopsis

Cited by 40 publications

References 56 publications

Association Mapping for Fruit, Plant and Leaf Morphology Traits in Eggplant

Association Mapping for Fruit, Plant and Leaf Morphology Traits in Eggplant

A wheat homologue of <i>PHYTOCLOCK 1</i> is a candidate gene conferring the early heading phenotype to einkorn wheat

Multitasking β-catenin: from adhesion and transcription to RNA regulation

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