Pulvino-cortical interaction: An integrative role in the control of attention

Bourgeois, Alexia; Guedj, Carole; Carrera, Emmanuel; Vuilleumier, Patrik

doi:10.1016/j.neubiorev.2020.01.005

Cited by 37 publications

(24 citation statements)

References 140 publications

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“…Recent fMRI work has highlighted hippocampus and subcortical brain activity in higher-order cognitive functions (Bourgeois et al, 2020; Chiu & Egner, 2019). Our results reveal that aging effects on these regions are characterized by changes in both rhythmic and arrhythmic signal strength and temporal variability, with an overall slowing of deeper neural activity.…”

Section: Discussionmentioning

confidence: 99%

“…Cognitive decline is associated with brain atrophy and reduced task-related cortical activations relative to younger individuals (Spreng & Turner, 2019). However, the modifications of deep-brain neurophysiological activity with age are seldom investigated, despite the role of hippocampus and subcortical structures in cognitive functioning (Bourgeois et al, 2020), and their early involvement in neurodegenerative pathologies (Gulyaeva, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Age-related changes of deep-brain neurophysiological activity

Hinault

Baillet

Courtney

2022

Preprint

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Cognitive decline with age is associated with brain atrophy and reduced brain activations, but the underlying neurophysiological mechanisms are unclear, especially in deeper brain structures primarily affected by healthy aging or neurodegenerative processes. Here, we characterize time-resolved, resting-state magnetoencephalography activity of the hippocampus and subcortical brain regions in a large cohort of healthy young and older volunteers from the Cam-CAN open repository. The data show age-related changes in both rhythmic and arrhythmic signal strength and temporal variability in multiple deeper brain regions, including the hippocampus, striatum, and thalamus. We observe a slowing of neural activity in deeper brain regions, which echoes previous reports of cortical slowing. We also report reduced occipito-parietal alpha peak associated with increased theta-band activity and signal variability in the hippocampus, an effect that may reflect compensatory processes as theta activity and variability were more strongly expressed when cognitive performances are preserved. Overall, this study advances the understanding of the biological nature of inter-individual variability in aging. The data provide new insight of how hippocampus and subcortical neurophysiological activity evolve with biological age, and highlight frequency-specific effects associated with cognitive decline vs. cognitive maintenance.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Age-related changes of deep-brain neurophysiological activity

Hinault

Baillet

Courtney

2022

Preprint

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“…PulN is anatomically divided into discrete, functionally differentiated subdivisions (e.g., Bourgeois et al, 2020 ; Guedj and Vuilleumier, 2020 ). For example, the “visual pulvinar,” consisting of its inferior (PI) and lateral (PL) subdivisions, has dense connections with early visual sensory regions ( Guedj and Vuilleumier, 2020 ) and likely plays a modulatory role in visual information processing ( de Souza et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Disease-Specific Contribution of Pulvinar Dysfunction to Impaired Emotion Recognition in Schizophrenia

Martı́nez

Tobe

Gaspar

et al. 2022

Front. Behav. Neurosci.

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One important aspect for managing social interactions is the ability to perceive and respond to facial expressions rapidly and accurately. This ability is highly dependent upon intact processing within both cortical and subcortical components of the early visual pathways. Social cognitive deficits, including face emotion recognition (FER) deficits, are characteristic of several neuropsychiatric disorders including schizophrenia (Sz) and autism spectrum disorders (ASD). Here, we investigated potential visual sensory contributions to FER deficits in Sz (n = 28, 8/20 female/male; age 21–54 years) and adult ASD (n = 20, 4/16 female/male; age 19–43 years) participants compared to neurotypical (n = 30, 8/22 female/male; age 19–54 years) controls using task-based fMRI during an implicit static/dynamic FER task. Compared to neurotypical controls, both Sz (d = 1.97) and ASD (d = 1.13) participants had significantly lower FER scores which interrelated with diminished activation of the superior temporal sulcus (STS). In Sz, STS deficits were predicted by reduced activation of early visual regions (d = 0.85, p = 0.002) and of the pulvinar nucleus of the thalamus (d = 0.44, p = 0.042), along with impaired cortico-pulvinar interaction. By contrast, ASD participants showed patterns of increased early visual cortical (d = 1.03, p = 0.001) and pulvinar (d = 0.71, p = 0.015) activation. Large effect-size structural and histological abnormalities of pulvinar have previously been documented in Sz. Moreover, we have recently demonstrated impaired pulvinar activation to simple visual stimuli in Sz. Here, we provide the first demonstration of a disease-specific contribution of impaired pulvinar activation to social cognitive impairment in Sz.

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“…Individuals with AGU are likely to have deficits in executive functioning and slowed processing speed. 24 , 25 , 26 , 27 …”

Section: Introductionmentioning

confidence: 99%

A cross‐sectional natural history study of aspartylglucosaminuria

et al. 2022

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Aspartylglucosaminuria (AGU) is a rare lysosomal storage disorder that causes stagnation of development in adolescence and neurodegeneration in early adulthood. Precision therapies, including gene transfer therapy, are in development with a goal of taking advantage of the slow clinical course. Understanding of disease natural history and identification of disease‐relevant biomarkers are important steps in clinical trial readiness. We describe the clinical features of a diverse population of patients with AGU, including potential imaging and electrophysiological biomarkers. This is a single‐center, cross‐sectional study of the clinical, neuropsychological, electrophysiological, and imaging characteristics of AGU. A comprehensive assessment of eight participants (5 Non‐Finnish) revealed a mean non‐verbal IQ (NVIQ) of 70.25 ± 10.33 which decreased with age (rs = −0.85, p = 0.008). All participants demonstrated deficits in communication and gross/fine motor dysfunction. Auditory and visual evoked potentials demonstrated abnormalities in one or both modalities in 7 of 8 subjects, suggesting sensory pathway dysfunction. Brain imaging demonstrated T2 FLAIR hypointensity in the pulvinar nuclei and cerebral atrophy, as previously shown in the Finnish AGU population. Magnetic resonance spectroscopy (MRS) showed a 5.1 ppm peak corresponding to the toxic substrate (GlcNAc‐Asn), which accumulates in AGU. Our results showed there was no significant difference between Finnish and Non‐Finnish patients, and performance on standardized cognitive and motor testing was similar to prior studies. Age‐related changes on functional assessments and disease‐relevant abnormalities on surrogate biomarkers, such as MRS, could be used as outcome measures in a clinical trial.

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Pulvino-cortical interaction: An integrative role in the control of attention

Cited by 37 publications

References 140 publications

Age-related changes of deep-brain neurophysiological activity

Age-related changes of deep-brain neurophysiological activity

Disease-Specific Contribution of Pulvinar Dysfunction to Impaired Emotion Recognition in Schizophrenia

A cross‐sectional natural history study of aspartylglucosaminuria

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