The safety and effectiveness of puncture radiofrequency thermal and pulsed effects on the spinal nerves and their branches in the treatment of patients suffering from degenerative-dystrophic diseases of the spine are evaluated. The study included clinical and experimental parts. In the clinical part of the study, the treatment results of 96 patients with degenerative- dystrophic diseases of the spine were analyzed. 66 patients underwent radiofrequency denervation of the intervertebral joints and radiofrequency modulation of the spinal ganglia. 30 patients received conservative treatment. The observation period was 12 months. The dynamics of the severity of pain on a digital rating scale and the degree of disability according to the Oswestry questionnaire a year after treatment were studied. A comparative analysis of the effectiveness of radiofrequency denervation of the intervertebral joints and radiofrequency modulation of the spinal ganglia with the effectiveness of conservative treatment was performed. In the experimental part of the study, histological changes in the spinal nerves and their nodes after radiofrequency pulse modulation were studied in 14 rats of the standard breed. The results of the study showed the high clinical efficacy of radiofrequency ablation in the treatment of vertebrogenic pain syndromes and the safety of the procedure, as well as its significant advantage over conservative treatment. Thus, radiofrequency denervation of the intervertebral joints and radiofrequency pulse modulation of the sensitive nodes of the spinal nerves, being relatively safe procedures, can significantly improve the quality of life and significantly reduce the severity of pain in patients with facet syndrome in the cervical spine from 7 to 0,5 points, in in the thoracic region – from 6,5 to 1 point and in the lumbar region – from 8 to 2 points, in patients with radiculopathy – from 8 to 2 points on a digital rating scale.