Pulsed Magnetic Field Therapy Increases Tensile Strength in a Rat Achilles’ Tendon Repair Model

Strauch, Berish; Patel, Mitesh; Rosen, Daniel J.; Mahadevia, Soham; Brindzei, Nelia; Pilla, Arthur A.

doi:10.1016/j.jhsa.2006.03.024

Cited by 68 publications

(48 citation statements)

References 22 publications

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“…Although still not completely elucidated, the mechanism of action of EMF signals at the molecular and cellular level is now much better understood and strongly suggests that ion/ligand binding in a regulatory cascade could be the primary signal transduction pathway [Pilla, 1974;Brighton et al, 2001;Aaron et al, 2004]. Furthermore, successful a priori configurations of physiologically effective waveforms, created by tuning the frequency spectrum of the exogenous electric field to that of a given ion binding pathway, have recently been reported [Pilla et al, 1999;Pilla, 2006;Strauch et al, 2006Strauch et al, , 2007Heden and Pilla, 2008]. The precise knowledge of how specific EMF configurations affect reactivity of biological processes could offer an additional tool for the armamentarium of the health care provider.…”

Section: Discussionmentioning

confidence: 99%

A Lorentz model for weak magnetic field bioeffects: Part II—Secondary transduction mechanisms and measures of reactivity

Muehsam

Pilla

2009

Bioelectromagnetics

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In Part I it was shown that the thermal component of the motion of a charged particle in an oscillator potential, that is, within a molecular binding site, rotates at the Larmor frequency in an applied magnetic field. It was also shown that the Larmor angular frequency is independent of the thermal noise strength and thus offers a mechanism for the biological detection of weak (microT-range) magnetic fields. Part II addresses the question of how the Larmor trajectory could affect biological reactivity. The projection of the motion onto a Cartesian axis measures the nonuniformity of the Larmor trajectory in AC and combined AC/DC magnetic fields, suggesting a means of assessing resonances. A physically meaningful measure of reactivity based upon the classical oscillator trajectory is suggested, and the problem of initial conditions is addressed through averaging over AC phases. AC resonance frequencies occur at the Larmor frequency and at other frequencies, and are dependent upon the ratio of AC/DC amplitudes and target kinetics via binding lifetime. The model is compared with experimental data reported for a test of the ion parametric resonance (IPR) model on data from Ca2+ flux in membrane vesicles, neurite outgrowth from PC-12 cells and a cell-free calmodulin-dependent myosin phosphorylation system, and suggests Mg2+ is the target for these systems. The results do not require multiple-ion targets, selection of isotopes, or additional curve fitting. The sole fitting parameter is the binding lifetime of the target system and the results shown are consistent with the literature on binding kinetics.

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Section: Discussionmentioning

confidence: 99%

A Lorentz model for weak magnetic field bioeffects: Part II—Secondary transduction mechanisms and measures of reactivity

Muehsam

Pilla

2009

Bioelectromagnetics

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“…In fact, EMF improves osteogenic phase of the healing process 22 by favouring the bone formation and healing through increased blood flow 23 , proliferation, differentiation and maturation of osteoblasts 24 . It can even accelerate the recovery of the tensile strength after tendon injury 25 .…”

Section: Effect Of Electromagnetic Field On Biomoleculesmentioning

confidence: 99%

Advances in Electromagnetic Therapy for Wound Healing

Madduri¹,

Anand²,

Kohli³

et al. 2018

Def. Life. Sc. Jl.

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Understanding the molecular basis of wound healing and tissue regeneration continues to remain as one of the major challenges in modern medicine. Wound healing is a complex procedure involving various cellular mechanism. Though high frequency electromagnetic fields are reported to cause cancer, birth defects and DNA damage, electromagnetic field at low intensity and low frequency can be effectively used for wound healing and for many more medical applications. Low intensity-low frequency pulsed electromagnetic therapy is evidenced to have a significant impact on wound repair and regeneration. It provides a non-invasive reparative technique to treat an injury. In vitro studies reported a significant effect of electromagnetic field on neovascularisation and angiogenesis. There are also many pieces of evidence which support its efficiency in reducing the duration of wound healing and improving the tensile strength of scars. Here, we compared the traditional stigma associated with pulsed electromagnetic fields and weighed them with its potential therapeutic effect on wound healing. Furthermore, emphasised the need for more focused research to determine the therapeutic strategies and optimised parameters of pulsed electromagnetic field that can assure efficient wound healing and regeneration.

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“…In a report by Kao et al, exposing wounds in diabetic mice to PSWD resulted in significantly increased dermal cell proliferation and collagen synthesis [57]. A number of animal studies have also shown improved healing responses to PSWD treatment [56,58,59]. Nonthermal pulsed electromagnetic fields have been reported to induce nitric oxide through a Ca 2+ /calmodulin signaling pathway [60].…”

Section: Biological Effects Of Nonthermal Shortwave Therapiesmentioning

confidence: 99%

The Case for Over-the-Counter Shortwave Therapy: Safe and Effective Devices for Pain Management

Rawe

2013

Pain Manage.

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Pulsed shortwave diathermy, an electromagnetic therapy, has been in clinical use for acute and chronic musculoskeletal pain for many decades. Innovation, miniaturization and advances in technology have allowed for the development of a new generation of shortwave devices that deliver a localized, low fixed dose of shortwave therapy. Clinical research has shown that these novel shortwave devices can be used safely in order to reduce acute and chronic pain, as well as the need for pain medications. Their ease of use and safety profile make low-dose shortwave devices an attractive alternative, or adjunct therapy, to pharmacological-based pain therapies.

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Pulsed Magnetic Field Therapy Increases Tensile Strength in a Rat Achilles’ Tendon Repair Model

Cited by 68 publications

References 22 publications

A Lorentz model for weak magnetic field bioeffects: Part II—Secondary transduction mechanisms and measures of reactivity

A Lorentz model for weak magnetic field bioeffects: Part II—Secondary transduction mechanisms and measures of reactivity

Advances in Electromagnetic Therapy for Wound Healing

The Case for Over-the-Counter Shortwave Therapy: Safe and Effective Devices for Pain Management

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