Pulsed Laser Deposition of Bioceramic Hydroxyapatite Thin Films  on Polymer Materials

Hontsu, Shigeki; Nakamori, Masaya; Tabata, Hitoshi; Ishii, Junya; Kawai, Tomoji

doi:10.1143/jjap.35.l1208

Cited by 30 publications

(8 citation statements)

References 10 publications

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“…Thus, it is necessary to modify the surface of medical PI catheters with biomaterials to effectively improve their affinity with skin tissue. According to previous reports, it was investigated that PI surfaces were modified by hydroxyapatite, 5 ion beam irradiation, 6 poly-(dimethylsiloxane), 7 and hydrophilic diamine monomers. 8 These methods were effective in preventing percutaneous genital infections but are not sufficient for practical use.…”

Section: ■ Introductionmentioning

confidence: 99%

Adsorption of Porphyrin in Orthogonally Stacked Mesoporous Silica Films: Implications for Surface Modification of Biomedical Polyimide

Nakajima

Chai

Endo

et al. 2023

ACS Appl. Nano Mater.

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An oriented cylindrical mesoporous silica (MPS) film has been synthesized on rubbing-treated (rubbed) polyimide (PI), which has the potential to be used as a surface-modified technology for biomedical catheters. However, the oriented cylindrical MPS film lacked isotropic mechanical properties because the cylindrical mesostructures were uniaxially oriented. Thus, it is possible to improve the isotropic properties of cylindrical MPS films by crosslaminating their cylindrical mesostructure. In this study, an orthogonally stacked and cylindrically oriented MPS film with two layers (2-L-MPS) was successfully synthesized through the following processes: (i) The 1st-layer-oriented MPS film was synthesized on the 1st-layer-rubbed PI film. (ii) The 2nd-layer-rubbed PI film was coated on the 1st-layer-oriented MPS film where the rubbing direction was perpendicular to that of the 1st-layer-rubbed PI film. (iii) The 2nd-layer-oriented MPS film was synthesized on the 2nd-layer-rubbed PI film. As for the 2-L-MPS film, it was proved that the orthogonally stacked and cylindrically oriented MPS film with 2-layer from the φ-scan XRD patterns, and the pore diameters of the 1st-and 2nd-layer-oriented MPS films were 3.7 and 4.8 nm from the Barrett−Joyner−Halenda (BJH) pore size distributions. The isotropic mechanical property of the 2-L-MPS film is thought to be enhanced by orthogonal stacking. Subsequently, the 2-L-MPS films were immersed into α,β,γ,δ-tetrakis(1methylpyridinium-4-yl)porphyrin p-toluenesulfonate (TMPyP) solutions with different concentrations, and the structures of the immersed 2-L-MPS films were evaluated and the adsorption states of TMPyP were investigated. The mesostructures of the 2-L-MPS films were still maintained after being immersed in the TMPyP solutions. Moreover, 2-L-MPS showed the different molecular adsorption states of TMPyP at the 1st-and 2nd-layer-oriented mesopores because of the difference in the pore size between each MPS layer. In the future, it is expected to be applied as a surface modification technology to endue biomedical materials such as PI catheters with excellent mechanical properties and oriented cell adhesion properties. Moreover, it has the potential to be used as a coating material that loads two drug molecules with different molecular diameters and releases them in a sustained manner by utilizing the difference in the pore size between the 1st-and 2nd-layer-oriented mesopores.

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Section: ■ Introductionmentioning

confidence: 99%

Adsorption of Porphyrin in Orthogonally Stacked Mesoporous Silica Films: Implications for Surface Modification of Biomedical Polyimide

Nakajima

Chai

Endo

et al. 2023

ACS Appl. Nano Mater.

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“…Previous studies have successfully prepared a hydroxyapatite film on the material surface by pulsed laser deposition (PLD) [ 27 ]. This technology may be used to prepare films with consistent chemical composition, high continuity, compact structure, and high bonding strength between the film and matrix.…”

Section: Introductionmentioning

confidence: 99%

Structural Characterization and Osseointegrative Properties of Pulsed Laser-Deposited Fluorinated Hydroxyapatite Films on Nano-Zirconia for Implant Applications

Komasa

Hontsu

et al. 2022

IJMS

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Standard zirconia implants used in restoration still present problems related to inertness and long-term stability. Various physicochemical approaches have been used to modify the implant surfaces to improve early and late bone-to-implant integration; however, no ideal surface modification has been reported. This study used pulsed laser deposition to deposit a fluorinated hydroxyapatite (FHA) film on a zirconia implant to create a biologically active surface. The film prepared was uniform, dense, and crack-free, and exhibited granular surface droplets; it also presented excellent mechanical strength and favorable biological behavior. The FHA-coated implant was implanted on the femur of Sprague–Dawley rats, and various tests and analyses were performed. Results show that the in vitro initial cell activity on the FHA-coated samples was enhanced. In addition, higher alkaline phosphatase activity and cell mineralization were detected in cells cultured on the FHA-coated groups. Further, the newly formed bone volume of the FHA-coated group was higher than that of the bare micro-adjusted composite nano-zirconia (NANOZR) group. Therefore, the FHA film facilitated osseointegration and may improve the long-term survival rates of dental implants, and could become part of a new treatment technology for implant surfaces, promoting further optimization of NANOZR implant materials.

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“…We have also evaluated the biocompatibility of each. [4][5][6] These apatite materials are highly biocompatible, and when cells are cultured on thin layers, proliferation and differentiation are 2 to 3 times faster than on titanium. These materials can thus be useful culture scaffolds.…”

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confidence: 99%

“…These molecules, atoms and ions react with the atmosphere gas (O 2 þ H 2 O, partial pressure was approximately 0.8 mTorr) on the substrate. These conditions were investigated to obtain the best biocompatibility for the HAp films, [4][5][6] except for the substrate temperature during the deposition (room temperature). Here, thermal heating of the substrate is generally needed for the deposition of high quality HAp thin films.…”

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confidence: 99%

Preparation of Freestanding Hydroxyapatite Membranes with Excellent Biocompatibility and Flexibility

Nishikawa

Hatanaka

Kusünoki

et al. 2008

Appl. Phys. Express

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Hydroxyapatite (HAp) is one of the most widely used materials for tissue culture scaffolding in regenerative medicine. To apply HAp as a suitable material for tissue culture scaffolding, we have developed freestanding HAp membranes that can be directly transplanted “as is” into a diseased site after tissue culturing. These freestanding HAp membranes are highly biocompatible, provide early cell proliferation and differentiation, and their flexibility allows some degree of configuration to the target site. This tissue culture scaffold is ideal from the standpoint of harvesting tissue and directly transplanting it to the diseased site.

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Pulsed Laser Deposition of Bioceramic Hydroxyapatite Thin Films on Polymer Materials

Cited by 30 publications

References 10 publications

Adsorption of Porphyrin in Orthogonally Stacked Mesoporous Silica Films: Implications for Surface Modification of Biomedical Polyimide

Adsorption of Porphyrin in Orthogonally Stacked Mesoporous Silica Films: Implications for Surface Modification of Biomedical Polyimide

Structural Characterization and Osseointegrative Properties of Pulsed Laser-Deposited Fluorinated Hydroxyapatite Films on Nano-Zirconia for Implant Applications

Preparation of Freestanding Hydroxyapatite Membranes with Excellent Biocompatibility and Flexibility

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