Pulsed large volume injection gas chromatography coupled with electron-capture negative ionization quadrupole mass spectrometry for simultaneous determination of typical halogenated persistent organic pollutants

Abstract

A pulsed large-volume injection gas chromatography coupled with electron-capture negative ionization quadrupole mass spectrometry (pLVI-GC/ECNI-qMS) was developed for the simultaneous determination of typical halogenated persistent organic pollutants (H-POPs). By monitoring the characteristic ions of large mass-to-charge ratio (m/z) for each of the H-POPs rather than the chlorine and/or bromine ions, this method avoided the possible interferences arising from the H-POPs themselves and from complex matrices encountered frequently in current GC/qMS methods; and allowed, on the other hand, the use of 13 C-labeled and perdeuterated analogues as internal standards for reliable quantification. pLVI up to 120 L improved the instrumental detection limits down to pg-fg mL Ϫ1

Optimisation of the analytical method for octa-, nona- and deca-brominated diphenyl ethers using gas chromatography–quadrupole mass spectrometry and isotope dilution

“…The value in this study was one order of magnitude lower than those obtained by others using bench top GC-EI-Sector-MS [14], LC-LIT-MS [18] and LC-triple quadrupole-MS [20], and were close to the levels obtained using GC-ECNI-MS [15,28] and GC-ICP-MS [19]. Although there is no information on IDL for GC-EI-Sector-MS, it was reported that its sensitivity is the same as that of GC-ECNI-MS [15,28] and GC-ICP-MS [19]. Although the sensitivity of this method was 10 times lower than that of GC-ECNI-MS [16], this method was more selective.…”

Improved GC/ECNI-MS sensitivity of decabromodiphenyl ether determination on 30 m columns by increasing the carrier gas flow after a modified gel permeation chromatographic cleanup protocol employing cyclohexane/ethyl acetate as eluent

“…Hence, we propose that the positive results primarily resulted from reduced diffusion effects owing to the shorter retention time. It should be noted that the GC/ECNI-MS sensitivity of BDE-209 can be improved on certain instruments by increasing the ion source temperature [37]. In this present case, we observed an improvement by $20% when the ion source temperature was increased from 150 C to 300 C. This effect adds to the effect obtained with our high flow method.…”

Evaluation of BDE-47 Hydroxylation Metabolic Pathways Based on a Strong Electron-Withdrawing Pentafluorobenzoyl Derivatization Gas Chromatography/Electron Capture Negative Ionization Quadrupole Mass Spectrometry

“…One had to increase the sample volume, for example, using a pulsed large-volume injection technique, to see the structure-informative fragment ions of PBDEs during a GC/ECNI-qMS. 31 In the case of OH- (Table S1, Supporting Information) can be used for identification.…”