Pulsed gas introduction into quadrupole ion traps

Emary, W. Bart; Kaiser, R. E.; Kenttämaa, Hilkka I.; Cooks, R. Graham

doi:10.1016/1044-0305(90)85006-8

Cited by 26 publications

(13 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are series of mobile and portable instruments introduced by the Cooks group (Gao et al, 2006;Fico et al, 2007;Keil et al, 2007;Janfelt et al, 2008;Yang et al, 2008;Ouyang et al, 2009;Huang et al, 2010), which enable the use of ambient ion sources. These small ion traps use a pulsed gas inlet to run with very small pumps and still maintain the vacuum (Emary et al, 1990). The pulsed gas inlet allows the connection to ambient ionization techniques (Collings & Romaschin, 2009).…”

Section: B Mass Spectrometric Instrumentation Including Mobile Instmentioning

confidence: 99%

Real‐time monitoring of exhaled drugs by mass spectrometry

Berchtold

Bosilkovska

Daali

et al. 2013

Mass Spectrometry Reviews

View full text Add to dashboard Cite

Future individualized patient treatment will need tools to monitor the dose and effects of administrated drugs. Mass spectrometry may become the method of choice to monitor drugs in real time by analyzing exhaled breath. This review describes the monitoring of exhaled drugs in real time by mass spectrometry. The biological background as well as the relevant physical properties of exhaled drugs are delineated. The feasibility of detecting and monitoring exhaled drugs is discussed in several examples. The mass spectrometric tools that are currently available to analyze breath in real time are reviewed. The technical needs and state of the art for on-site measurements by mass spectrometry are also discussed in detail. Off-line methods, which give support and are an important source of information for real-time measurements, are also discussed. Finally, some examples of drugs that have already been successfully detected in exhaled breath, including propofol, fentanyl, methadone, nicotine, and valproic acid are presented. Real-time monitoring of exhaled drugs by mass spectrometry is a relatively new field, which is still in the early stages of development. New technologies promise substantial benefit for future patient monitoring and treatment.

show abstract

Section: B Mass Spectrometric Instrumentation Including Mobile Instmentioning

confidence: 99%

Real‐time monitoring of exhaled drugs by mass spectrometry

Berchtold

Bosilkovska

Daali

et al. 2013

Mass Spectrometry Reviews

View full text Add to dashboard Cite

show abstract

“…Pulsed CI gas introduction has been used before and is advantageous because of the reduced additional gas load and the controllable timing of CI. 44 …”

Section: Electron Impact and Chemical Ionizationmentioning

confidence: 97%

Design and performance of an atmospheric pressure sampling interface for ion-trap/time-of-flight mass spectrometry

Setz

Schmitz

Zenobi

2006

Review of Scientific Instruments

View full text Add to dashboard Cite

An ion-trap/time-of-flight mass spectrometer in combination with an atmospheric pressure sampling interface was developed in order to simultaneously profit from the ease of sample handling at ambient pressure, from the storage and accumulation capabilities of an ion trap, and from the acquisition speed and sensitivity of a time-of-flight mass spectrometer. The sampling interface is an intermediate-pressure vacuum manifold that serves to enrich sampled analytes by jet separation with respect to the carrier gas ͑air͒ and simultaneously maintain vacuum conditions inside the ion-trap/ time-of-flight instrument. Neutral analyte molecules are sampled and later ionized either by electron impact or chemical ionization. Ion accumulation is performed with a rf-only quadrupole ion trap with ground potential on the end caps during storage. For mass analysis, the trap's electrodes serve as a pulsed ion source for the attached linear time-of-flight mass spectrometer. In addition, laser desorbed molecules can also be sampled with this kind of instrument. Successful operation is shown by analyzing volatile substances ͑aniline, bromobenzene, styrene, and perfluorotributylamine͒, as well as laser-desorbed organic solids. Figures of merit include a sensitivity of 10 ppm, resolving power of 300 and demonstration of a mass spectrum of laser-desorbed anthracene with a signal-to-noise ratio of 270.

show abstract

“…Contributions to mass spectra from ion-molecule reactions such as this may be minimized by using a pulsed-valve inlet for the CI reagent gas rather than acquiring EI spectra in the presence of the reagent gas [18]. However, the full width at half maximum of a gas pulse can exceed 100 ms, and thus it may be necessary to add some delay period between alternate scans to allow the pressure of the pulsed CI gas to be pumped down to pressures sufficiently low to minimize ion-molecule reactions.…”

Section: Reaction With Analyte Ions Formed During Ei Of Reagent Gasmentioning

confidence: 99%

Reaction of analyte ions with neutral chemical ionization gas

Hart

McLuckey

Glish

1992

J. Am. Soc. Mass Spectrom.

View full text Add to dashboard Cite

Analytical Chemistry Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA Ion-molecule reactions of neutral methane with analyte ions under normal methane chemical ionization conditions are discussed. Reactant ions can be generated by direct electron ionization (EI) fragmentation, chemical ionization (CI) fragmentation, or collision-induced dissociation (CID). Examples in which products of such reactions appear in mass spectra in both conventional CI sources in "beam" instruments and low pressure CI in a quadrupole ion trap are presented. Also shown is an example in which MS/MS product ions react with neutral methane used for CI in an ion trap. It is shown that it is relatively straightforward to recognize such reactions in a quadrupole ion trap and in certain cases to minimize or preclude them. Effects of various operating parameters have been investigated and are discussed.

show abstract

Pulsed gas introduction into quadrupole ion traps

Cited by 26 publications

References 10 publications

Real‐time monitoring of exhaled drugs by mass spectrometry

Real‐time monitoring of exhaled drugs by mass spectrometry

Design and performance of an atmospheric pressure sampling interface for ion-trap/time-of-flight mass spectrometry

Reaction of analyte ions with neutral chemical ionization gas

Contact Info

Product

Resources

About