Pulsed erbium:YAG laser‐assisted autologous epidermal punch grafting in vitiligo

Sachdev, Mukta; Shankar, Deepa

doi:10.1046/j.1365-4362.2000.00097.x

Cited by 24 publications

(22 citation statements)

References 26 publications

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“…We found 10 studies and one meta‐analysis in the literature involving the surgical management of lip vitiligo 8–18 . The studies included data from a total of 1728 patients, 312 with lip vitiligo.…”

Section: Resultsmentioning

confidence: 99%

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Autologous melanocyte transfer via epidermal grafts for lip vitiligo

et al. 2006

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Background Vitiligo of the lips is a common concern of great psychologic consequence. Medical therapies are often ineffective due mainly to the absence of hair follicles. The transfer of melanocytes or melanocyte‐bearing skin by a surgical procedure may repigment this condition. Only a few surgical modalities have been successful in this “difficult to treat” site. Objective To assess the effectiveness of autologous melanocyte transfer by epidermal grafts for lip vitiligo and to review the literature on the surgical correction of lip vitiligo. Methods Twenty‐six vitiligo patients (20 women and six men; age range, 13–43 years; mean, 26.8 years) having 31 affected lips with stable disease were included in the study. The suction blisters were raised using our own modified device on the lateral aspect of the thigh. The roofs of the blisters were transferred to the dermabraded recipient area. The dressing, together with the grafts, was removed on day 8. Patients were given photochemotherapy for 6 weeks. In addition, meta‐analysis of the published literature on the surgical management of lip vitiligo was also performed. Results Complete repigmentation was observed in 27 of the 31 lip areas (87%) in 23 of 25 patients (92%) in whom a follow‐up for 6 months or more was available. Complications observed were persistent hyperpigmentation in 12 lips and reactivation of herpes in one patient. Minimal hyperpigmentation was seen in most of the remaining lips. The results of the meta‐analysis revealed that the success rate varies from 32.5% to 100% with various surgical procedures. Conclusion Autologous melanocyte transfer is an effective and safe therapeutic option for stable vitiligo of the lips. It is cosmetically more acceptable, as there is no abnormal keratinization, which is a problem associated with dermo‐epidermal grafts.

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Section: Resultsmentioning

confidence: 99%

“…We found 10 studies and one meta-analysis in the literature involving the surgical management of lip vitiligo. [8][9][10][11][12][13][14][15][16][17][18] The studies included data from a total of 1728 patients, 312 with lip vitiligo. The meta-analysis included data from 777 patients, 27 with lip vitiligo.…”

Section: Resultsmentioning

confidence: 99%

Autologous melanocyte transfer via epidermal grafts for lip vitiligo

et al. 2006

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“…Alternatively, wound healing is divided into four phases: (i) hemostasis; (ii) inflammatory; (iii) proliferative; and (iv) remodeling 14 . The series of phases occurs within 2 months after grafting, inducing various cytokines such as β‐fibroblast growth factor, tissue growth factor‐α and tissue growth factor‐β 10 . In particular, increasing evidence indicates that mast cells might play a pivotal role in wound repair 15 .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of 1-mm minigrafts in treating vitiligo depends on patient age, disease site and vitiligo subtype

Katô

Furuhashi

Ito

et al. 2011

The Journal of Dermatology

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Vitiligo vulgaris is a refractory skin disease. Treatment modalities include topical steroids, phototherapy, suction blister roof grafts and cellular grafting techniques. Adverse effects may occur, however, and some cases remain unresponsive to treatment. To evaluate the efficacy of small (1-mm) punch minigraft therapy in relation to patient age, disease site, disease duration and vitiligo subtype. We used a recently developed disposable 1.0-mm punch apparatus to perform minigraft therapy in 20 patients with either generalized (n = 4), segmental (n = 9) or limited (n = 7) vitiligo, and evaluated the area and rate of repigmentation in relation to patient age, disease site, disease duration and vitiligo subtype. The area of repigmentation was significantly greater in patients with segmental vitiligo (n = 9) than in those with generalized vitiligo (n = 4). Repigmentation covered a broader area and occurred more quickly in patients under 15 years of age than in those over 20 years of age (n = 9). Disease duration did not affect the repigmentation rate. The results of the present study suggest that 1-mm minigrafts are effective for treating patients with vitiligo. Better results occurred in patients under 15 years of age, patients with facial grafts, and patients with segmental and limited subtypes.

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“…In a smaller study, 13 patients had erbium-doped yttrium aluminium garnet laser ablation of the recipient site with repigmentation in 92%. 150 The addition of light therapy may provide additional benefit. PG and NBUVB phototherapy appear to provide better repigmentation, with success in 86.36% after just one postsurgical exposure to NBUVB light phototherapy.…”

Section: Punch Graftmentioning

confidence: 99%