Pulsed EPR methods in the angstrom to nanometre scale shed light on the conformational flexibility of a fluoride riboswitch
Laura Remmel,
Andreas Meyer,
Katrin Ackermann
et al.
Abstract:Riboswitches control gene regulation upon external stimuli such as environmental factors or ligand binding. The fluoride sensing riboswitch from Thermotoga petrophila is a complex regulatory RNA proposed to be involved in resistance to fluoride cytotoxicity. The details of structure and dynamics underpinning the regulatory mechanism are currently debated. Here we demonstrate that a combination of pulsed electron paramagnetic resonance (ESR/EPR) spectroscopies, detecting distances in the angstrom to nanometre r… Show more
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