Pulsed electromagnetic fields: promising treatment for osteoporosis

Wang, Tian Tian; Yang, Lin; Jiang, Jingwen; Liu, Y; Fan, Zhining; Zhong, Cheng; He, Chao

doi:10.1007/s00198-018-04822-6

Cited by 45 publications

(35 citation statements)

References 93 publications

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“…Although substantial studies demonstrate that PEMF improved bone microstructure in various osteoporotic animal models, the effects of PEMF on normal skeleton remain poorly investigated. Our current µCT results reveal that PEMF significantly increased femoral and vertebral bone mass and improved bone architecture in young adult rats.…”

Section: Discussionmentioning

confidence: 99%

“…Growing evidence suggests that PEMF or WBV stimulation partially preserved bone mass and strength in osteopenic animals induced with disuse, ovariectomy, and diabetes, nevertheless, whether the PEMF + WBV coupling signals can produce greater anti‐osteoporotic efficacy than single stimulation remains unknown. Moreover, no data to date report the potential age‐dependent skeletal response to either single or coupled stimulation with PEMF and WBV.…”

Section: Discussionmentioning

confidence: 99%

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Differential skeletal response in adult and aged rats to independent and combinatorial stimulation with pulsed electromagnetic fields and mechanical vibration

et al. 2019

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Pulsed electromagnetic fields (PEMFs) and whole‐body vibration (WBV) are proved to partially preserve bone mass/strength in hindlimb‐unloaded and ovariectomized animals. However, the potential age‐dependent skeletal response to either PEMF or WBV has not been fully investigated. Moreover, whether the coupled “mechano‐electro‐magnetic” signals can induce greater osteogenic potential than single stimulation remains unknown. Herein, 5‐month‐old or 20‐month‐old rats were assigned to the Control, PEMF, WBV, and PEMF + WBV groups. After 8‐week treatment, single PEMF/WBV enhanced bone mass, strength, and anabolism in 5‐month‐old rats, but not in 20‐month‐old rats. PEMF + WBV induced greater increase of bone quantity, quality, and anabolism than single PEMF/WBV in young adult rats. PEMF + WBV also inhibited bone loss in elderly rats by primarily improving osteoblast and osteocyte activity, but had no effects on bone resorption. PEMF + WBV upregulated the expression of various canonical Wnt ligands and downstream molecules (p‐GSK‐3β and β‐catenin), but had no impacts on noncanonical Wnt5a expression in aged skeleton, revealing the potential involvement of canonical Wnt signaling in bone anabolism of PEMF + WBV. This study not only reveals much weaker responsiveness of aged skeleton to single PEMF/WBV relative to young adult skeleton, but also presents a novel noninvasive approach based on combinatorial treatment with PEMF + WBV for improving bone health and preserving bone quantity/quality (especially for age‐related osteoporosis) with stronger anabolic effects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Differential skeletal response in adult and aged rats to independent and combinatorial stimulation with pulsed electromagnetic fields and mechanical vibration

et al. 2019

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“…Під впливом постійного та змінного імпульсного магнітного поля відзначається посилення метаболічних процесів в ділянці кісткового регенерату, в більш ранні терміни з'являються фібро-та остеобласти в ділянці регенерації, процес утворення кісткової речовини проходить інтенсивніше та у більш ранні терміни [45][46][47][48]. У низці досліджень на тваринах доведено, що магнітотерапії властива седативна, гіпотензивна, протизапальна, протинабрякова, знеболююча і трофіко-регенеративна дія [4,49,50].…”

Section: електрична стимуляціяunclassified

“…Проте, відкритим залишається питання щодо використання магнітотерапії за наявності металевих конструкцій у порожнині рота [44,39]. Також варто враховувати той факт, що незважаючи на свою сприятливу дію на організм, магнітні поля від 70 мТл і вище стають стресовими агентами і негативно впливають на діяльність низки функціональних систем [4,43,46]. Окрім цього, відсутність якісних клінічних спостережень ставить під сумнів клінічну ефективність цього методу.…”

Section: електрична стимуляціяunclassified

Modern Physical Methods of Stimulating the Bone Tissue Healing Processes

Vares¹,

Shtybel²

2019

Ukr. ž. med. bìol. sportu

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“…In vivo studies have shown that osteocytes always exist in a complex mechanical environment, which includes shear stress, tensile strain, and pressure (Iolascon et al, 2013). When stimulated by mechanical strain (Wang et al, 2019), osteocytes can regulate osteoblast proliferation and differentiation by releasing signaling molecules, such as nitric oxide, prostaglandin E2, and adenosine triphosphate (Bakker et al, 2001;Genetos et al, 2005). Studies have shown that bed-ridden patients and astronauts develop osteoporosis due to reduced mechanical bone stimulation, but the mechanism of this phenomenon remains unclear (Norvell et al, 2004;Sibonga, 2013;Yang et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Osteoblast and Osteoclast Activity Affect Bone Remodeling Upon Regulation by Mechanical Loading-Induced Leukemia Inhibitory Factor Expression in Osteocytes

Yang

et al. 2020

Front. Mol. Biosci.

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PurposeBone remodeling is affected by mechanical stimulation. Osteocytes are the primary mechanical load-sensing cells in the bone, and can regulate osteoblast and osteoclast activity, thus playing a key role in bone remodeling. Further, bone mass during exercise is also regulated by Leukemia inhibitory factor (LIF). This study aimed to investigate the role of LIF in the mechanical response of the bone, in vivo and in vitro, and to elucidate the mechanism by which osteocytes secrete LIF to regulate osteoblasts and osteoclasts.MethodsA tail-suspension (TS) mouse model was used in this study to mimic muscular disuse. ELISA and immunohistochemistry were performed to detect bone and serum LIF levels. Micro-computed tomography (CT) of the mouse femurs was performed to measure three-dimensional bone structure parameters. Fluid shear stress (FSS) and microgravity simulation experiments were performed to study mechanical stress-induced LIF secretion and its resultant effects. Bone marrow macrophages (BMMs) and bone mesenchymal stem cells (BMSCs) were cultured to induce in vitro osteoclastogenesis and osteogenesis, respectively.ResultsMicro-CT results showed that TS mice exhibited deteriorated bone microstructure and lower serum LIF expression. LIF secretion by osteocytes was promoted by FSS and was repressed in a microgravity environment. Further experiments showed that LIF could elevate the tartrate-resistant acid phosphatase activity in BMM-derived osteoclasts through the STAT3 signaling pathway. LIF also enhanced alkaline phosphatase staining and osteogenesis-related gene expression during the osteogenic differentiation of BMSCs.ConclusionMechanical loading affected LIF expression levels in osteocytes, thereby altering the balance between osteoclastogenesis and osteogenesis.

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Pulsed electromagnetic fields: promising treatment for osteoporosis

Cited by 45 publications

References 93 publications

Differential skeletal response in adult and aged rats to independent and combinatorial stimulation with pulsed electromagnetic fields and mechanical vibration

Differential skeletal response in adult and aged rats to independent and combinatorial stimulation with pulsed electromagnetic fields and mechanical vibration

Modern Physical Methods of Stimulating the Bone Tissue Healing Processes

Osteoblast and Osteoclast Activity Affect Bone Remodeling Upon Regulation by Mechanical Loading-Induced Leukemia Inhibitory Factor Expression in Osteocytes

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