Pulsed Electromagnetic Fields in Experimental Cutaneous Wound Healing in Rats

Patiño, Osvaldo; Grana, Daniel; Bolgiani, Alberto; Prezzavento, Gustavo; Miño, Jorge; Merlo, Alicia; Benaim, F

doi:10.1097/00004630-199611000-00009

Cited by 49 publications

(34 citation statements)

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“…Bertolino et al [2006] and Henry et al [2008] further proved the efficacy of gradient SMF with 160 and 2.3 mT, respectively, in hastening wound healing in rats. In the literature, more evidence has proven that low-amplitude PEMF could effectively improve wound concrescence, and shorten healing time [Ottani et al, 1988;Patino et al, 1996;Milgram et al, 2004;Athanasiou et al, 2007;Strauch et al, 2007;Callaghan et al, 2008]. However, we still lack an adequate scientific basis for achieving the optimal dosing parameter or treatment regimen of SMF and PEMF for the acceleration of wound healing [Colbert et al, 2009].…”

Section: Discussionmentioning

confidence: 99%

Effects of 180 mT static magnetic fields on diabetic wound healing in rats

Jing

Shen

Cai

et al. 2010

Bioelectromagnetics

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Diabetic wound (DW) problems are becoming a formidable clinical challenge due to the sharp increase in the diabetic population and the high incidence of DW. Static magnetic field (SMF) therapy, an inexpensive and accessible noninvasive method, has been proven to be effective on various tissue repairs. However, the issue of the therapeutic effect of SMF on DW healing has never been investigated. The objective of this study was to systematically evaluate the effect of a 180 mT moderate-intensity gradient SMF on DW healing in streptozotocin-induced diabetic rats. Forty-eight 3-month-old male Sprague-Dawley rats (32 diabetic and 16 non-diabetic rats) were assigned to three equal groups: normal wound, DW, and DW + SMF groups. An open circular wound with 1.5 cm diameter was created in the dorsum. The wound was covered with a dressing and the magnet was fixed on top of the dressing. On days 5, 12, and 19, four rats of each group were euthanized and gross wound area, histology and tensile strength were evaluated. The wound area determination suggested that SMF significantly increased the healing rate and reduced the gross healing time. This result was further confirmed by histological observations. The wound tensile strength, reflecting the amount and quality of collagen deposition, increased to a larger extent in the DW + SMF group on days 12 and 19 compared with the DW group. The results indicated that 180 mT SMF presented a beneficial effect on DW healing, and implied the clinical potential of SMF therapy in accelerating DW repair and releasing the psychological and physical burdens of diabetic patients.

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Section: Discussionmentioning

confidence: 99%

Effects of 180 mT static magnetic fields on diabetic wound healing in rats

Jing

Shen

Cai

et al. 2010

Bioelectromagnetics

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“…Although the literature supports a potential therapeutic benefit of pulsed electromagnetic field (PEMF) application to aid in the treatment of non-union bone fractures (2,17) and osteoarthritis (5), the acceleration of wound healing (4,32,41), and the modulation of angiogenesis (14,42), direct evidence supporting the therapeutic use of static magnetic fields (SMF) is less established. Static magnetic fields are of particular interest because they are the primary field used in many of the over-the-counter products presently on the market, with ϳ5 billion dollars worldwide and 500 million dollars in the U.S. per annum being spent on magnetic field therapy (10).…”

mentioning

confidence: 99%

Acute exposure to a moderate strength static magnetic field reduces edema formation in rats

Morris¹,

Skalak²

2008

American Journal of Physiology-Heart and Circulatory Physiology

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“…Injured area significantly decreased in PEMF exposed animals compared to the control groups 49 . This was further supported by Callaghan 50 , et al who evidenced through their findings that PEMF accelerated the overall healing of wounds, particularly during the early stages of tissue repair process (up to 9 days).…”

Section: Elf-emf and Rattus Norvegicusmentioning

confidence: 79%

Advances in Electromagnetic Therapy for Wound Healing

Madduri¹,

Anand²,

Kohli³

et al. 2018

Def. Life. Sc. Jl.

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Understanding the molecular basis of wound healing and tissue regeneration continues to remain as one of the major challenges in modern medicine. Wound healing is a complex procedure involving various cellular mechanism. Though high frequency electromagnetic fields are reported to cause cancer, birth defects and DNA damage, electromagnetic field at low intensity and low frequency can be effectively used for wound healing and for many more medical applications. Low intensity-low frequency pulsed electromagnetic therapy is evidenced to have a significant impact on wound repair and regeneration. It provides a non-invasive reparative technique to treat an injury. In vitro studies reported a significant effect of electromagnetic field on neovascularisation and angiogenesis. There are also many pieces of evidence which support its efficiency in reducing the duration of wound healing and improving the tensile strength of scars. Here, we compared the traditional stigma associated with pulsed electromagnetic fields and weighed them with its potential therapeutic effect on wound healing. Furthermore, emphasised the need for more focused research to determine the therapeutic strategies and optimised parameters of pulsed electromagnetic field that can assure efficient wound healing and regeneration.

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Pulsed Electromagnetic Fields in Experimental Cutaneous Wound Healing in Rats

Cited by 49 publications

References 0 publications

Effects of 180 mT static magnetic fields on diabetic wound healing in rats

Effects of 180 mT static magnetic fields on diabetic wound healing in rats

Acute exposure to a moderate strength static magnetic field reduces edema formation in rats

Advances in Electromagnetic Therapy for Wound Healing

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