Pulsed electromagnetic fields as a promising therapy for glucocorticoid-induced osteoporosis

Zhang, Tianxiao; Zhao, Zhentang; Wang, Tiantian

doi:10.3389/fbioe.2023.1103515

Cited by 2 publications

(2 citation statements)

References 106 publications

(140 reference statements)

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“…Similar results were obtained by other authors [62,63]. A recent review showed positive effects of PEMFs in the treatment of osteoporosis in 23 out of 24 studies included in the study.…”

Section: Osteopenia and Osteoporosissupporting

confidence: 90%

Pulsed Electromagnetic Field Stimulation in Bone Healing and Joint Preservation: A Narrative Review of the Literature

Caruso,

Massari,

Lentini

et al. 2024

Applied Sciences

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Background: Biophysical stimulation therapy, Pulsed Electromagnetic Fields (PEMFs) and Capacitively Coupled Electric Fields (CCEFs) have significantly increased in the last twenty years. Due to this, it is necessary to have clear information regarding their efficacy, therapeutic indications and expected objectives. Application fields: There is a unanimous opinion regarding the usefulness of applying biophysical therapy on the bone compartment both in terms of the tissue-healing process and the symptoms associated with this situation. Differently, but no less important, positive results were observed in the joint compartment, especially with regard to the inhibition of the inflammatory process. Good results for chondroprotection were obtained in vitro and after a surgical procedure. New studies have shown the effectiveness also in cases of osteoporosis. Conclusions: The effectiveness of PEMFs and CCEFs on the bone-healing process and on joint preservation in the orthopedic and traumatology fields has consolidated evidence in the literature. We have also found positive results for symptoms and patient compliance with rehabilitation therapies. Therefore, their notable applications can be envisaged in the fields of prosthetic surgery and sports medicine.

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“…Similar results were obtained by other authors [62,63]. A recent review showed positive effects of PEMFs in the treatment of osteoporosis in 23 out of 24 studies included in the study.…”

Section: Osteopenia and Osteoporosissupporting

confidence: 90%

Pulsed Electromagnetic Field Stimulation in Bone Healing and Joint Preservation: A Narrative Review of the Literature

Caruso,

Massari,

Lentini

et al. 2024

Applied Sciences

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“…Osteoporosis fractures and delayed unions are two examples of bone disorders that can be treated with PEMF therapy [10]. By stimulating osteoblastogenesis and influencing calcium storage and mineral metabolism, PEMF increases both bone volume and density [11]. Electromagnetic field applications in rats, human red blood cells, and human hemoglobin cell-free models have shown that these stimuli can increase tissue oxygenation, microcirculation, and angiogenesis [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Pulsed Electromagnetic Fields Induce Skeletal Muscle Cell Repair by Sustaining the Expression of Proteins Involved in the Response to Cellular Damage and Oxidative Stress

Maiullari,

Cicirelli,

Picerno

et al. 2023

IJMS

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Pulsed electromagnetic fields (PEMF) are employed as a non-invasive medicinal therapy, especially in the orthopedic field to stimulate bone regeneration. However, the effect of PEMF on skeletal muscle cells (SkMC) has been understudied. Here, we studied the potentiality of 1.5 mT PEMF to stimulate early regeneration of human SkMC. We showed that human SkMC stimulated with 1.5 mT PEMF for four hours repeated for two days can stimulate cell proliferation without inducing cell apoptosis or significant impairment of the metabolic activity. Interestingly, when we simulated physical damage of the muscle tissue by a scratch, we found that the same PEMF treatment can speed up the regenerative process, inducing a more complete cell migration to close the scratch and wound healing. Moreover, we investigated the molecular pattern induced by PEMF among 26 stress-related cell proteins. We found that the expression of 10 proteins increased after two consecutive days of PEMF stimulation for 4 h, and most of them were involved in response processes to oxidative stress. Among these proteins, we found that heat shock protein 70 (HSP70), which can promote muscle recovery, inhibits apoptosis and decreases inflammation in skeletal muscle, together with thioredoxin, paraoxonase, and superoxide dismutase (SOD2), which can also promote skeletal muscle regeneration following injury. Altogether, these data support the possibility of using PEMF to increase SkMC regeneration and, for the first time, suggest a possible molecular mechanism, which consists of sustaining the expression of antioxidant enzymes to control the important inflammatory and oxidative process occurring following muscle damage.

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Pulsed electromagnetic fields as a promising therapy for glucocorticoid-induced osteoporosis

Cited by 2 publications

References 106 publications

Pulsed Electromagnetic Field Stimulation in Bone Healing and Joint Preservation: A Narrative Review of the Literature

Pulsed Electromagnetic Field Stimulation in Bone Healing and Joint Preservation: A Narrative Review of the Literature

Pulsed Electromagnetic Fields Induce Skeletal Muscle Cell Repair by Sustaining the Expression of Proteins Involved in the Response to Cellular Damage and Oxidative Stress

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