2000
DOI: 10.1002/jor.1100180417
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Pulsed electromagnetic field stimulation of MG63 osteoblast‐like cells affects differentiation and local factor production

Abstract: Pulsed electromagnetic field stimulation has been used to promote the healing of chronic nonunions and fractures with delayed healing, but relatively little is known about its effects on osteogenic cells or the mechanisms involved. The purpose of this study was to examine the response of osteoblast-like cells to a pulsed electromagnetic field signal used clinically and to determine if the signal modulates the production of autocrine factors associated with differentiation. Confluent cultures of MG63 human oste… Show more

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Cited by 158 publications
(174 citation statements)
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“…Three groups have demonstrated increases in the transcription of mRNA for several BMP in skeletal tissue with EMF exposure [7,37,51]. Increases in the transcription of TGFP mRNA suggest that the stimulation of TGFP expression may be a mechanism through which physical agents affect complex tissue behavior such as cell differentiation and through which the effects of EMF may be amplified [25,32,52]. Physical agents may be synergistic with endogenous synthesized, or exogenously applied, growth factors in repair.…”
Section: Resultsmentioning
confidence: 99%
“…Three groups have demonstrated increases in the transcription of mRNA for several BMP in skeletal tissue with EMF exposure [7,37,51]. Increases in the transcription of TGFP mRNA suggest that the stimulation of TGFP expression may be a mechanism through which physical agents affect complex tissue behavior such as cell differentiation and through which the effects of EMF may be amplified [25,32,52]. Physical agents may be synergistic with endogenous synthesized, or exogenously applied, growth factors in repair.…”
Section: Resultsmentioning
confidence: 99%
“…Most investigations on the mechanism of action of IC technology have been performed with the PEMF signal which is FDA approved for fracture healing but not spinal fusion [1,4,8,11,29,43,44,51,64]. There is only one study using the PEMF signal that is clinically approved for spinal fusions [61] and a few studies with CMF [11,20,21,58].…”
Section: Inductive Couplingmentioning
confidence: 99%
“…In addition, contradictory results have been reported. For example, cell proliferation, as assayed by cell number and 3 H-thymidine incorporation, have been reported to increase, 6 decrease, 15 and remain unaffected 15 by PEMF exposure. Similarly, the production of alkaline phosphatase has been reported to either increase 15,16 or decrease 17 following PEMF exposure.…”
Section: Introductionmentioning
confidence: 99%
“…For example, PEMF exposure has been associated with increases in Type I collagen, alkaline phosphatase, 7,13,15,16 total extracellular matrix, 18 and glycosaminoglycans. 19,20 However, it is not known if these changes are primary or secondary effects of PEMF exposure.…”
Section: Introductionmentioning
confidence: 99%