Pulsed electromagnetic field (PEMF) treatment for fracture healing

Boopalan, P.R.J.V.C.; Chittaranjan, Samuel; Balamurugan, Ramadass; Nandakumar, N. S.; Sabareeswaran, A; Mohanty, Mira

doi:10.1097/bco.0b013e318198e8b2

Cited by 8 publications

(5 citation statements)

References 17 publications

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“…He mentioned that PEMF therapy is very useful for the treatment of musculoskeletal disorder and pain. It was also found in literature survey [4] that PEMF is non-invasive and cost effective adjuvant treatment in experimental osteochondral defect healing. Dr. Sircus [5] posted the facts of pulse electromagnetic field therapy for relieving the pain of cancer.…”

Section: Introductionmentioning

confidence: 86%

Development of Low Cost Microcontroller based Pulse ElectroMagnetic Pulse Therapy System for Pain relief and Bone Healing

Roy¹,

Roy²

2014

IOSRJEEE

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Pulse Electromagnetic therapy is usually referred by doctors for clinical management of quick bone healing, repair of damaged tissues and as a quick remedy for pain. Various PEMT equipment are already available in market, but none of them are available as low cost consumer electronic device. Authors tried to develop a low cost version of micro controller controlled PEMT device. The design and construction method of this PEMT device has been thoroughly discussed in this paper. The prototype constructed not only met the low cost criteria but also was equally effective at pain management and bone healing.

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Section: Introductionmentioning

confidence: 86%

Development of Low Cost Microcontroller based Pulse ElectroMagnetic Pulse Therapy System for Pain relief and Bone Healing

Roy¹,

Roy²

2014

IOSRJEEE

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“…A microarray assay would reveal all growth factors expressed and this would be helpful to know since healing occurs due to an interrelation of growth factor expression at different time intervals. In a previous study quantitative PCR analysis showed increased expression of TGF-β1 and TGF-β2 after six weeks of PEMF stimulation [6].…”

Section: Discussionmentioning

confidence: 99%

“…In a previous study, local expression of TGF-β by treatment with pulsed magnetic field therapy resulted in better bone healing in animal study osteotomy models compared to controls [6]. Our hypothesis was that in full thickness articular cartilage defects resulting in marrow stimulation, growth factors delivered locally by pulsed electromagnetic field (PEMF) should help in the formation of hyaline cartilage.…”

Section: Introductionmentioning

confidence: 99%

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Pulsed electromagnetic field therapy results in healing of full thickness articular cartilage defect

Boopalan

Sabareeswaran

Livingston

et al. 2010

International Orthopaedics (SICOT)

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This study aimed to determine the efficacy of PEMF (pulsed electromagnetic field) treatment in experimental osteochondral defect healing in a rabbit model. The study was conducted on 12 New Zealand white rabbits. Six rabbits formed the study group and six rabbits the control group. The right knee joints of all 12 animals were exposed and a 3.5-mm diameter osteochondral defect was created in the trochlear groove. The defect was filled with calcium phosphate scaffold. Six animals from the study group were given PEMF of one hour duration once a day for six weeks with set parameters for frequency of 1 Hz, voltage 20 V, sine wave and current ±30 mA. At six weeks the animals were sacrificed and histological evaluation was done using H&E, Safranin O, Maissons trichrome staining and immunohistochemistry for type 2 collagen. The quality of the repair tissue was graded and compared between groups with the Wakitani histological grading scale and a statistical analysis was done. The total histological score was significantly better in the study group (p =0.002) with regeneration similar to adjacent normal hyaline cartilage. Immunohistochemistry for collagen type II was positive in the study group. PEMF stimulation of osteochondral defects with calcium phosphate scaffold is effective in hyaline cartilage formation. PEMF is a non-invasive and cost effective adjuvant treatment with salvage procedures such as abrasion chondroplasty and subchondral drilling.

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“…19 With regard to lineage differentiation, PEMF has well-documented physiological effects, which importantly include the upregulation of expression in TGFb superfamily members 20,21 demonstrating higher expression TGFb 1 and TGFb2, both known transcription factors associated with chondrogenic differentiation. 22,23 Fig. 1.…”

Section: Introductionmentioning

confidence: 99%

In vitro chondrogenic differentiation of human articular cartilage derived chondroprogenitors using pulsed electromagnetic field

Vinod

Kachroo

Rebekah

et al. 2021

Journal of Clinical Orthopaedics and Trauma

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Background:The ability to grow new cartilage remains the standard goal of any treatment strategy directed at cartilage repair. Chondroprogenitors have garnered interest due to their applicability in cell therapy. Pulsed electromagnetic field (PEMF) favors chondrogenesis by possible upregulation of genes belonging to TGFb superfamily. Since TGFb is implicated in chondrogenic signalling, the aim of the study was to evaluate the ability of PEMF to induce chondrogenesis via endogenous TGFb production in chondroprogenitors vs differentiation using chondrogenic medium inclusive of TGFb. Methods: Chondroprogenitors were harvested from three non-diseased human knee joints via fibronectin assay. Passage 3 pellets were subjected to four different culture conditions: a) negative control contained chondrogenic medium without TGFb2, b) positive control contained medium with TGFb2, c) PEMF 1 contained medium of negative control plus single exposure to PEMF and d) PEMF 2 contained medium of negative control plus multiple exposures to PEMF. Following differentiation (day 21), pellets were assessed for gene expression of ACAN, SOX9, COL2A1, TGFb1, TGFb2, and TGFb3. Alcian blue staining to detect glycosaminoglycan deposition was also performed. Medium supernatant was used to detect endogenous latent TGF-b1 levels using ELISA. Results: All study arms exhibited comparable gene expression without any significant difference. Although positive control and PEMF study arms demonstrated notably better staining than negative control, the level of latent TGF-b1 was seen to be significantly high in supernatant from positive control (P < 0.05) when compared to other groups. Conclusion: Our results indicate that PEMF induced chondrogenesis might involve other signalling molecules, which require further evaluation.

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Pulsed electromagnetic field (PEMF) treatment for fracture healing

Cited by 8 publications

References 17 publications

Development of Low Cost Microcontroller based Pulse ElectroMagnetic Pulse Therapy System for Pain relief and Bone Healing

Development of Low Cost Microcontroller based Pulse ElectroMagnetic Pulse Therapy System for Pain relief and Bone Healing

Pulsed electromagnetic field therapy results in healing of full thickness articular cartilage defect

In vitro chondrogenic differentiation of human articular cartilage derived chondroprogenitors using pulsed electromagnetic field

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