Pulsed‐Dye Laser and Retinoic Acid Delay Progression of Oral Squamous Cell Carcinoma: A Murine Model

Shah, Rahul K.; Valdez, Tulio A.; Wang, Zhi; Shapshay, Stanley M.

doi:10.1097/00005537-200107000-00013

Cited by 11 publications

(7 citation statements)

References 8 publications

(32 reference statements)

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“…Possibly, viral infections in VAD animals contribute to the development of pre-neoplastic changes in the lung that can, in some cases, progress to high-grade dysplasia and carcinoma [ 60 , 61 ]. The relationship between lung cancer and vitamin A precursors has been previously examined [ 62 , 63 , 64 , 65 , 66 ], and (as for other cancers) vitamin supplementation as a treatment for lung cancer has yielded variable results [ 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 ].…”

Section: Discussionmentioning

confidence: 99%

Consequences of Vitamin A Deficiency: Immunoglobulin Dysregulation, Squamous Cell Metaplasia, Infectious Disease, and Death

Surman

Penkert

Sealy

et al. 2020

IJMS

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Vitamin A is an important regulator of immune protection, but it is often overlooked in studies of infectious disease. Vitamin A binds an array of nuclear receptors (e.g., retinoic acid receptor, peroxisome proliferator-activated receptor, retinoid X receptor) and influences the barrier and immune cells responsible for pathogen control. Children and adults in developed and developing countries are often vitamin A-deficient or insufficient, characteristics associated with poor health outcomes. To gain a better understanding of the protective mechanisms influenced by vitamin A, we examined immune factors and epithelial barriers in vitamin A deficient (VAD) mice, vitamin D deficient (VDD) mice, double deficient (VAD+VDD) mice, and mice on a vitamin-replete diet (controls). Some mice received insults, including intraperitoneal injections with complete and incomplete Freund’s adjuvant (emulsified with PBS alone or with DNA + Fus-1 peptide) or intranasal inoculations with Sendai virus (SeV). Both before and after insults, the VAD and VAD+VDD mice exhibited abnormal serum immunoglobulin isotypes (e.g., elevated IgG2b levels, particularly in males) and cytokine/chemokine patterns (e.g., elevated eotaxin). Even without insult, when the VAD and VAD+VDD mice reached 3–6 months of age, they frequently exhibited opportunistic ascending bacterial urinary tract infections. There were high frequencies of nephropathy (squamous cell hyperplasia of the renal urothelium, renal scarring, and ascending pyelonephritis) and death in the VAD and VAD+VDD mice. When younger VAD mice were infected with SeV, the predominant lesion was squamous cell metaplasia of respiratory epithelium in lungs and bronchioles. Results highlight a critical role for vitamin A in the maintenance of healthy immune responses, epithelial cell integrity, and pathogen control.

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Section: Discussionmentioning

confidence: 99%

Consequences of Vitamin A Deficiency: Immunoglobulin Dysregulation, Squamous Cell Metaplasia, Infectious Disease, and Death

Surman

Penkert

Sealy

et al. 2020

IJMS

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“…Recent findings show that problems of potency or toxicity are likely to attend the use of any single strategy, and multiple strategies, synergizing each other, offer an exciting new option for cancer prevention [12]. Our previous studies indicate that the efficacy of tumor treatment is significantly improved when PDL is combined with retinoic acid [13]. The same principle should hold true when PDL is combined with Celecoxib.…”

Section: Discussionmentioning

confidence: 97%

Cancer “photo‐chemoprevention” with pulsed dye laser and celecoxib

2003

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“…Our previous studies in animal models have indicated a significant inhibitory effect in oral squamous cell carcinoma from PDL. 11 However, our success in using the laser MVT treatment is limited to nude mice bearing tumor by skin inoculation of oral squamous cell carcinoma. This model certainly provides the most expedient means of establishing the feasibility and efficacy of the new combined treatment.…”

Section: Discussionmentioning

confidence: 99%

The Role of Laser Vascular Targeting and Retinoic Acid in Oral Cancer Inhibition

Polavaram¹,

Fuentes²,

Shapshay³

et al. 2003

The Laryngoscope

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Pulsed‐Dye Laser and Retinoic Acid Delay Progression of Oral Squamous Cell Carcinoma: A Murine Model

Abstract: This study demonstrated the superiority of a single treatment with the PDL coupled with retinoic acid to delay the progression of cancer when compared with treatment with retinoic acid alone, thus introducing a novel strategy in cancer control.

Cited by 11 publications

References 8 publications

Consequences of Vitamin A Deficiency: Immunoglobulin Dysregulation, Squamous Cell Metaplasia, Infectious Disease, and Death

Consequences of Vitamin A Deficiency: Immunoglobulin Dysregulation, Squamous Cell Metaplasia, Infectious Disease, and Death

Cancer “photo‐chemoprevention” with pulsed dye laser and celecoxib

The Role of Laser Vascular Targeting and Retinoic Acid in Oral Cancer Inhibition

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