2012
DOI: 10.1111/j.1467-2995.2012.00740.x
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Pulsed delivery of inhaled nitric oxide counteracts hypoxaemia during 2.5 hours of inhalation anaesthesia in dorsally recumbent horses

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Cited by 25 publications
(51 citation statements)
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“…), aerosolized salbutamol (Robertson & Bailey ), pulsed application of nitric oxide (NO) (Nyman et al. ), and spontaneous ventilation with PEEP (sPEEP) (Beadle et al. ; Hall & Trim ).…”
Section: Introductionmentioning
confidence: 99%
“…), aerosolized salbutamol (Robertson & Bailey ), pulsed application of nitric oxide (NO) (Nyman et al. ), and spontaneous ventilation with PEEP (sPEEP) (Beadle et al. ; Hall & Trim ).…”
Section: Introductionmentioning
confidence: 99%
“…Although continuous delivery of iNO over the entire inspiratory phase of ventilation did not improve arterial oxygenation in a previous study 23 of halothane-anesthetized horses, PiNO administration during the early phase of inspiration did counteract hypoxemia and Qs/Qt formation in dorsally recumbent 13,15 and laterally recumbent 11,12 isoflurane-anesthetized horses. It appears that pulsing iNO in the first 30% to 45% of the inspiratory phase, as was done in the present study, is the most effective method to improve oxygenation in anesthetized horses.…”
Section: Discussionmentioning
confidence: 53%
“…It appears that pulsing iNO in the first 30% to 45% of the inspiratory phase, as was done in the present study, is the most effective method to improve oxygenation in anesthetized horses. 12,13,23 However, the pulse dose can be too small to be effective, and PiNO administration in only 20% of the inspiratory phase can result in minimal or no improvement. 12 Administration of PiNO at 45% of the inspiratory phase in a horse with a small tidal volume, as for 1 horse in this study, can result in less improvement than when a full dose is delivered.…”
Section: Discussionmentioning
confidence: 97%
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“…Using this technique, hypoxaemia is treated by redirecting blood flow, or pulmonary perfusion, to the ventilated regions of the lung rather than by changing ventilation of the lung . However, PiNO does not affect ventilation and hypercarbia developed in all or most horses in previous studies . These findings were also confirmed in a clinical study where spontaneously breathing horses undergoing colic surgery treated with PiNO remained hypercarbic despite improved arterial oxygenation .…”
Section: Introductionmentioning
confidence: 77%