Pulsed Cavitational Ultrasound: A Noninvasive Technology for Controlled Tissue Ablation (Histotripsy) in the Rabbit Kidney

Roberts, William W.; Hall, Timothy L.; Ives, Kimberly; Wolf, J. Stuart; Fowlkes, J. Brian; Cain, Charles A.

doi:10.1016/s0022-5347(05)00141-2

Cited by 291 publications

(222 citation statements)

References 19 publications

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“…Pigs are more often used because their kidney most closely resembles the structural features of the human kidney (Sampaio et al, 1998). On the other hand, rabbits have been used as urologic models in many studies, such as radiofrequency ablation (RFA) (Miao et al, 2001) magnetic resonance imaging (Hynynen et al, 1996), histotripsy (Roberts et al, 2006), lithotripsy (Fernández et al, 2009) and partial nephrectomy (Tyritzis et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Morphometry and Vascularization of the Rabbit Kidneys (Oryctolagus cuniculus)

et al. 2015

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SUMMARY: Rabbits have been used as urologic models in many studies. The aim of this study was to characterize the renal morphology and anatomical variations of the renal pedicle in rabbit. The research ethics committee of Rio de Janeiro Federal Rural University approved this study. The animals were obtained from the university's necropsy unit. Dissections were performed in 50 adult rabbits, male and females, without macroscopic renal pathology. Kidney measurements were made with a digital caliper: length, width, and thickness. The length and origin of the renal arteries and main branches and length of the renal veins were also determined. The terminology of Nomina Anatomica Veterinaria was followed. The mean and standard deviation of the length of the right kidney was 3.150±0.2588 cm in males and 3.127±0.3769 cm in females and in the left kidney was 3.083±0.0818 cm in males and 3.162±0.0848 cm in females. The width of the right kidney was 1.933±0.0848 cm in males and 1.996±0.0680 cm in females and in the left kidney was 1.850±0.0659 cm in males and 2.004±0.0940 cm in females. There was no significant difference in the measurements between the two sexes and antimeres and in the measures of renal vessels in relation to sex, but the left artery and renal vein were always larger than the right in both sexes. The results of the present study are expected to contribute to the body of knowledge in the field of comparative and applied anatomy.

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Section: Introductionmentioning

confidence: 99%

Morphometry and Vascularization of the Rabbit Kidneys (Oryctolagus cuniculus)

et al. 2015

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“…We term the approach described above as "boiling histotripsy," in contrast to the previously reported HIFU procedure called "histotripsy," in which much shorter (microsecond-as opposed to millisecond-duration) pulses are used to generate a cavitation cloud in tissue and the activity of the cloud (as opposed to a boiling bubble) is used for tissue erosion (15). Cavitation-cloud histotripsy has been recently demonstrated in vivo for the fragmentation of rabbit kidney (16), canine prostate (17), and porcine liver (18). The treatment was shown to be well tolerated; however, to achieve the focal peak negative pressures sufficient for cavitation cloud formation, very large and highly focused (f-number 0.8) transducers are required, as well as the amplifiers capable of providing extremely high instantaneous power (on the order of several kilowatts).…”

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confidence: 99%

Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model

Khokhlova

Wang

Simon

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Significance High intensity focused ultrasound (HIFU) therapy is a promising, clinically adopted method of noninvasive tissue ablation used to treat both benign and malignant conditions. This work presents, to our knowledge, the first in vivo validation of a previously developed HIFU-based method that allows for noninvasive fractionation of targeted tissue into subcellular debris—boiling histotripsy—in a large animal model. While fractionating the targeted soft tissue, boiling histotripsy is shown to spare the adjacent connective tissue structures such as blood vessels. The process can be readily targeted and monitored by B-mode ultrasound. The resulting tissue debris are liquid, which provides a potential clinical benefit over thermal ablation in the treatment of tumors that exert uncomfortable pressure on surrounding tissues.

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“…In diagnostic ultrasound, contrast may be improved by injecting microbubbles [7]. In therapeutic ultrasound, e.g., shock-wave lithotripsy [12], high-intensity focused ultrasound [18] or histotripsy [17], bubbles form and respond to the incoming pulses. In these applications, cavitation bubbles may be produced directly in soft tissue, a viscoelastic medium.…”

Section: Introductionmentioning

confidence: 99%