Pulsed 450 nm blue light significantly inactivates Propionibacterium acnes more than continuous wave blue light

Masson-Meyers, Daniela Santos; Bumah, Violet V.; Castel, Chris; Castel, Dawn; Enwemeka, Chukuka S.

doi:10.1016/j.jphotobiol.2019.111719

Cited by 29 publications

(26 citation statements)

References 27 publications

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“…Recent studies demonstrate that various wavelengths in the blue spectrum are antimicrobial against the deadly methicillin-resistant Staphylococcus aureus (MRSA) [31,32,35,45], Escherichia coli [38,40], Helicobacter pylori [39], Listeria monocytogenes [40], Pseudomonas aeruginosa [38], Salmonella [37], Acinetobacter baumannii [41], Aggregatibacter actinomycetemcomitans [46], Propionibacterium acnes [34][35][36]47], Neisseria gonorrhoeae [48][49][50], Porphyromonas gingivalis [51][52][53], Fusobacterium nucleatum [51], and others [42,50,[54][55][56][57][58]. An analysis of the Nobel-winning work of Finsen, supports these blue light studies, because it shows that the Finsen Lamp, used to heal many with tuberculosis infection, did not produce UV as Finsen believed; rather, it produces light in the violet/blue range [59] (Fig.…”

Section: Antimicrobial Blue Lightmentioning

confidence: 99%

“…Indeed, porphyrins with absorption peaks in the 405 to 470 nm range have been identified in microbial cells [39,[46][47][48][49][50][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79]. In three recent papers [34][35][36], we took advantage of this theory by timing in vitro irradiation of P. acnes and MRSA to coincide with periods of abundant endogenous porphyrins and hence elicit maximal bacterial suppression. The outcome was impressive.…”

Section: Antimicrobial Blue Lightmentioning

confidence: 99%

“…These prospects make urgent the need to intensify efforts to test the effect of blue light on common viruses, including COVID-19. Further, that light in the visible spectrum constitutes the basis for photodynamic treatment of plasma to inactivate several viruses, including herpes simplex and human immunodeficiency virus (HIV) [95][96][97], offers strong reason to suggest that blue light-particularly pulsed blue light, which recent reports have shown to be 40 to 100 times more potent than continuous wave blue light [33][34][35]-has great potential to inactivate coronaviruses.…”

Section: Photobiomodulation and Acute Pulmonary Disordermentioning

confidence: 99%

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Light as a potential treatment for pandemic coronavirus infections: A perspective

Enwemeka

Bumah

Masson-Meyers

2020

Journal of Photochemistry and Photobiology B: Biology

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Section: Antimicrobial Blue Lightmentioning

confidence: 99%

Section: Antimicrobial Blue Lightmentioning

confidence: 99%

Section: Photobiomodulation and Acute Pulmonary Disordermentioning

confidence: 99%

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Light as a potential treatment for pandemic coronavirus infections: A perspective

Enwemeka

Bumah

Masson-Meyers

2020

Journal of Photochemistry and Photobiology B: Biology

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“…The important bactericidal effect of blue light spectrum when acting on most microbes has been demonstrated; pulsed wave blue light is more efficient than continuous wave [ 150 ].…”

Section: Photodynamic Therapy With Blue Laser and Curcumin In Hepamentioning

confidence: 99%

“…In addition to blue light laser devices, updated technology has designed and manufactured LED devices that are much cheaper and easier to use by patients to fight viral infections, even at home [ 149 , 150 ].…”

Section: Photodynamic Therapy With Blue Laser and Curcumin In Hepamentioning

confidence: 99%

Curcumin and Photobiomodulation in Chronic Viral Hepatitis and Hepatocellular Carcinoma

Ailioaie

Litscher

2020

IJMS

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Immune modulation is a very modern medical field for targeting viral infections. In the race to develop the best immune modulator against viruses, curcumin, as a natural product, is inexpensive, without side effects, and can stimulate very well certain areas of the human immune system. As a bright yellow component of turmeric spice, curcumin has been the subject of thousands of scientific and clinical studies in recent decades to prove its powerful antioxidant properties and anticancer effects. Curcumin has been shown to influence inter- and intracellular signaling pathways, with direct effects on gene expression of the antioxidant proteins and those that regulate the immunity. Experimental studies have shown that curcumin modulates several enzyme systems, reduces nitrosative stress, increases the antioxidant capacity, and decreases the lipid peroxidation, protecting against fatty liver pathogenesis and fibrotic changes. Hepatitis B virus (HBV) affects millions of people worldwide, having sometimes a dramatic evolution to chronic aggressive infection, cirrhosis, and hepatocellular carcinoma. All up-to-date treatments are limited, there is still a gap in the scientific knowledge, and a sterilization cure may not yet be possible with the removal of both covalently closed circular DNA (cccDNA) and the embedded HBV DNA. With a maximum light absorption at 420 nm, the cytotoxicity of curcumin as photosensitizer could be expanded by the intravenous blue laser blood irradiation (IVBLBI) or photobiomodulation in patients with chronic hepatitis B infection, Hepatitis B e-antigen (HBeAg)-positive, noncirrhotic, but nonresponsive to classical therapy. Photobiomodulation increases DNA repair by the biosynthesis of complex molecules with antioxidant properties, the outset of repairing enzyme systems and new phospholipids for regenerating the cell membranes. UltraBioavailable Curcumin and blue laser photobiomodulation could suppress the virus and control better the disease by reducing inflammation/fibrosis and stopping the progression of chronic hepatitis, reversing fibrosis, and diminishing the progression of cirrhosis, and decreasing the incidence of hepatocellular carcinoma. Photodynamic therapy with blue light and curcumin opens new avenues for the effective prevention and cure of chronic liver infections and hepatocellular carcinoma. Blue laser light and UltraBioavailable Curcumin could be a new valuable alternative for medical applications in chronic B viral hepatitis and hepatocarcinoma, saving millions of lives.

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The viability of human cells irradiated with 470-nm light at various radiant energies in vitro

et al. 2021

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Pulsed 450 nm blue light significantly inactivates Propionibacterium acnes more than continuous wave blue light

Cited by 29 publications

References 27 publications

Light as a potential treatment for pandemic coronavirus infections: A perspective

Light as a potential treatment for pandemic coronavirus infections: A perspective

Curcumin and Photobiomodulation in Chronic Viral Hepatitis and Hepatocellular Carcinoma

The viability of human cells irradiated with 470-nm light at various radiant energies in vitro

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