Pulse-Waveform Analysis of Normal Population using Laser Speckle Flowgraphy

Tsuda, S.; Kunikata, Hiroshi; Shimura, Masahiko; Aizawa, Naoko; Omodaka, Kazuko; Shiga, Yukihiro; Yasuda, Masayuki; Yokoyama, Yû; Nakazawa, Toru

doi:10.3109/02713683.2014.905608

Cited by 58 publications

(80 citation statements)

References 39 publications

(54 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…S1B, left). 30,31 If the waveform is bilaterally symmetrical, the skew will be zero. When the peak of the waveform is shifted leftward, the skew will become higher.…”

Section: Pulse Waveform Analyses On Lsfgmentioning

confidence: 99%

“…The skew increases as the slope of the waveform after the peak becomes more concave. The skew is calculated as follows 30,31 :…”

Section: Pulse Waveform Analyses On Lsfgmentioning

confidence: 99%

“…10 With recent advances of LSFG, various parameters can be automatically calculated to analyze the pulse waveform of MBR averaged in a single heartbeat, 14,[27][28][29][30][31] including the skew, blowout time (BOT), and acceleration time index (ATI), all of which are expressed as absolute values. These new indices have been reported to reflect the augmentation of blood flow resistance basically due to arterial sclerosis as well as aging (i.e., the skew increases and BOT decreases), [27][28][29][30] showing significant correlations with branchial-ankle pulse wave velocity 27 and the stage of glaucoma. 31 The current study demonstrates functional data to further complement the rationale of circulatory abnormalities as the pathogenesis of CSC, showing sequential changes in these pulse waveform parameters on LSFG.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Pulse Waveform Changes in Macular Choroidal Hemodynamics With Regression of Acute Central Serous Chorioretinopathy

Saito

Hirooka

et al. 2015

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

“…S1B, left). 30,31 If the waveform is bilaterally symmetrical, the skew will be zero. When the peak of the waveform is shifted leftward, the skew will become higher.…”

Section: Pulse Waveform Analyses On Lsfgmentioning

confidence: 99%

“…The skew increases as the slope of the waveform after the peak becomes more concave. The skew is calculated as follows 30,31 :…”

Section: Pulse Waveform Analyses On Lsfgmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Pulse Waveform Changes in Macular Choroidal Hemodynamics With Regression of Acute Central Serous Chorioretinopathy

Saito

Hirooka

et al. 2015

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

“…However, in a normal population, an earlier study showed that MA was negatively correlated with age, whereas MTwas stable regardless of age. 45 Recently, pulse waveform parameters derived from MBR have been introduced clinically, including skew, blowout score (BOS), rising rate, falling rate, and blowout time (BOT; Figs. 1, 2).…”

mentioning

confidence: 99%

“…29,30,45 Furthermore, multiple regression analysis has revealed that MT falling rate is an independent factor indicating age and conversely, that age is also an independent factor indicating MT falling rate. 45 The significant correlation of MT falling rate with age suggests that it may be a new candidate biomarker for age-dependent microcirculation (Figs. 2, 3).…”

mentioning

confidence: 99%

Recent Clinical Applications of Laser Speckle Flowgraphy in Eyes with Retinal Disease

Kunikata¹,

Nakazawa²

2016

Asia-Pacific Journal of Ophthalmology

Self Cite

View full text Add to dashboard Cite

Retinal diseases related to ischemia, such as diabetic retinopathy, are the main cause of blindness worldwide. However, the pathogenesis of these diseases remains unclear, as does the time course of associated changes in ocular blood flow. Laser speckle flowgraphy (LSFG), which uses the laser speckle phenomenon to detect and quantify ocular circulation, is a promising candidate for a noninvasive method to measure ocular blood flow in living eyes. A recently developed LSFG measurement parameter, mean blur rate (MBR), can serve as a quantitative and reproducible index of retinal blood cell velocity. Mean blur rate can be used in the study of retinal diseases to evaluate microcirculation in the retinal vessels, choroid, and optic nerve head. In addition to overall MBR (MA), LSFG measurements of optic nerve head microcirculation can be divided into vessel-area MBR (MV) and tissue-area MBR (MT). Absolute values for MT have been shown to be linearly correlated with capillary blood flow, regardless of fundus pigmentation. Recently, there has been an increasing number of reports on the clinical applications of LSFG in retinal disease.

show abstract

Functional imaging of human retina using integrated multispectral and laser speckle contrast imaging

Feng

Zou

et al. 2021

Journal of Biophotonics

View full text Add to dashboard Cite

A novel integration of retinal multispectral imaging (MSI), retinal oximetry and laser speckle contrast imaging (LSCI) is presented for functional imaging of retinal blood vessels that could potentially allow early detection or monitoring of functional changes. We designed and built a cost-effective, scalable, retinal imaging instrument that integrates structural and functional retinal imaging techniques, including MSI, retinal oximetry and LSCI. Color fundus imaging was performed with 470 nm, 550 nm and 600 nm wavelength light emitting diode (LED) illumination. Retinal oximetry was performed using 550 nm and 600 nm LED illumination. LSCI of blood flow was performed using 850 nm laser diode illumination at 82 frames per second. LSCI can visualize retinal and choroidal vasculature without requiring exogenous contrast agents and can provide time-resolved information on blood flow, generating a cardiac pulse waveform from retinal vasculature. The technology can rapidly acquire structural MSI images, retinal oximetry and LSCI blood flow information in a simplified clinical workflow without requiring patients to move between instruments. Results from multiple modalities can be combined and registered to provide structural as well as functional information on the retina. These advances can reduce barriers for clinical adoption, accelerating research using MSI, retinal oximetry and LSCI of blood flow for diagnosis, monitoring and elucidating disease pathogenesis.

show abstract

Pulse-Waveform Analysis of Normal Population using Laser Speckle Flowgraphy

Abstract: The significant correlation of LSFG-measured tissue area falling rate with age suggests that it may be a new candidate biomarker for age-dependent microcirculation.

Cited by 58 publications

References 39 publications

Pulse Waveform Changes in Macular Choroidal Hemodynamics With Regression of Acute Central Serous Chorioretinopathy

Pulse Waveform Changes in Macular Choroidal Hemodynamics With Regression of Acute Central Serous Chorioretinopathy

Recent Clinical Applications of Laser Speckle Flowgraphy in Eyes with Retinal Disease

Functional imaging of human retina using integrated multispectral and laser speckle contrast imaging

Contact Info

Product

Resources

About